Characteristics and Prognostic Relevance of Ventricular Arrhythmia in Patients with Myocarditis
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Characteristics and Prognostic Relevance of Ventricular Arrhythmia in Patients with Myocarditis. / Kahle, Ann-Kathrin; Güde, Rebekka; Schwarzl, Jana M; Münkler, Paula; Akbulak, Ruken Ö; Jahnke, Charlotte; Bohnen, Sebastian; Würger, Tilman; Schwarzl, Michael; Willems, Stephan; Radunski, Ulf K; Meyer, Christian.
In: J CARDIOVASC DEV DIS, Vol. 9, No. 8, 243, 29.07.2022.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Characteristics and Prognostic Relevance of Ventricular Arrhythmia in Patients with Myocarditis
AU - Kahle, Ann-Kathrin
AU - Güde, Rebekka
AU - Schwarzl, Jana M
AU - Münkler, Paula
AU - Akbulak, Ruken Ö
AU - Jahnke, Charlotte
AU - Bohnen, Sebastian
AU - Würger, Tilman
AU - Schwarzl, Michael
AU - Willems, Stephan
AU - Radunski, Ulf K
AU - Meyer, Christian
PY - 2022/7/29
Y1 - 2022/7/29
N2 - Myocarditis is characterized by various clinical manifestations, with ventricular arrhythmia (VA) as a frequent symptom at initial presentation. Here, we investigated characteristics and prognostic relevance of VA in patients with myocarditis. The study population consisted of 76 patients with myocarditis, verified by biopsy and/or cardiac magnetic resonance (CMR) imaging, including 38 consecutive patients with VA (45 ± 3 years, 68% male) vs. 38 patients without VA (NVA) (38 ± 2 years, 84% male) serving as a control group. VA was monomorphic ventricular tachycardia in 55% of patients, premature ventricular complexes in 50% and ventricular fibrillation in 29%. The left ventricular ejection fraction at baseline was 47 ± 2% vs. 40 ± 3% in VA vs. NVA patients (p = 0.069). CMR showed late gadolinium enhancement more often in VA patients (94% vs. 69%; p = 0.016), incorporating 17.6 ± 1.8% vs. 8.2 ± 1.3% of myocardial mass (p < 0.001). Radiofrequency catheter ablation for VA was initially performed in nine (24%) patients, of whom five remained free from any recurrence over 24 ± 3 months. Taken together, in patients with myocarditis, reduced left ventricular ejection fraction does not predict VA occurrence but CMR shows late gadolinium enhancement more frequently and to a larger extent in VA than in NVA patients, potentially guiding catheter ablation as a reasonable treatment of VA in this population.
AB - Myocarditis is characterized by various clinical manifestations, with ventricular arrhythmia (VA) as a frequent symptom at initial presentation. Here, we investigated characteristics and prognostic relevance of VA in patients with myocarditis. The study population consisted of 76 patients with myocarditis, verified by biopsy and/or cardiac magnetic resonance (CMR) imaging, including 38 consecutive patients with VA (45 ± 3 years, 68% male) vs. 38 patients without VA (NVA) (38 ± 2 years, 84% male) serving as a control group. VA was monomorphic ventricular tachycardia in 55% of patients, premature ventricular complexes in 50% and ventricular fibrillation in 29%. The left ventricular ejection fraction at baseline was 47 ± 2% vs. 40 ± 3% in VA vs. NVA patients (p = 0.069). CMR showed late gadolinium enhancement more often in VA patients (94% vs. 69%; p = 0.016), incorporating 17.6 ± 1.8% vs. 8.2 ± 1.3% of myocardial mass (p < 0.001). Radiofrequency catheter ablation for VA was initially performed in nine (24%) patients, of whom five remained free from any recurrence over 24 ± 3 months. Taken together, in patients with myocarditis, reduced left ventricular ejection fraction does not predict VA occurrence but CMR shows late gadolinium enhancement more frequently and to a larger extent in VA than in NVA patients, potentially guiding catheter ablation as a reasonable treatment of VA in this population.
U2 - 10.3390/jcdd9080243
DO - 10.3390/jcdd9080243
M3 - SCORING: Journal article
C2 - 36005407
VL - 9
JO - J CARDIOVASC DEV DIS
JF - J CARDIOVASC DEV DIS
SN - 2308-3425
IS - 8
M1 - 243
ER -
