PURPOSE: To assess a new flat panel volume computed tomography (FP-VCT) with very high isotropic spatial resolution as well as high Z-axis coverage. MATERIALS AND METHODS: The prototype of an FP-VCT scanner with a detector cell size of 0.2 mm was used for numerous phantom studies, specimen examinations, and animal research projects. RESULTS: The high spatial resolution of the new system can be used to accurately determine solid tumor volume, thus allowing for earlier assessment of the therapeutic response. In animal experimentation, whole-body perfusion mapping of mice is feasible. The high spatial resolution also improves the classification of coronary artery atherosclerotic plaques in the isolated post mortem human heart. With the depiction of intramyocardial segments of the coronary arteries, investigations of myocardial collateral circulation are feasible. In skeletal applications, an accurate analysis of the smallest bony structures, e. g., petrous bone and dental preparations, can be successfully performed, as well as investigations of repetitive studies of fracture healing and the treatment of osteoporosis. CONCLUSION: The introduction of FP-VCT opens up new applications for CT, including the field of molecular imaging, which are highly attractive for future clinical applications. Present limitations include limited temporal resolution and necessitate further improvement of the system.
