Changes in sleep architecture in German Armed Forces personnel with posttraumatic stress disorder compared with depressed and healthy control subjects
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Changes in sleep architecture in German Armed Forces personnel with posttraumatic stress disorder compared with depressed and healthy control subjects. / Haberland, Laura; Höllmer, Helge; Schulz, Holger; Spiegelhalder, Kai; Gorzka, Robert.
In: PLOS ONE, Vol. 14, No. 4, 2019, p. e0215355.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in sleep architecture in German Armed Forces personnel with posttraumatic stress disorder compared with depressed and healthy control subjects
AU - Haberland, Laura
AU - Höllmer, Helge
AU - Schulz, Holger
AU - Spiegelhalder, Kai
AU - Gorzka, Robert
PY - 2019
Y1 - 2019
N2 - BACKGROUND: This study compares the sleep architecture of patients with posttraumatic stress disorder (PTSD) with that of both patients with depression and subjects with no mental disorder.METHOD: 45 German armed forces personnel with PTSD, 72 German armed forces personnel with depression and 24 healthy control subjects underwent 24-hour polysomnography. The effects of group membership, medication and the statistical interaction of group and medication were analysed for the following variables: sleep onset latency, REM sleep latency, slow-wave sleep and REM sleep percentages.RESULTS: Sleep onset latency was significantly prolonged in both the PTSD and the depression group. Moreover, psychotropic medication was associated with significantly prolonged REM sleep latency.CONCLUSION: The impact on sleep onset latency is of special clinical relevance in that according to preliminary studies, it is of major importance for subjective sleep quality. In contrast to the other parameters, an increase in sleep onset latency results in a subjective reduction in sleep quality which can lead to hyperarousal and increased preoccupation with sleep, which in turn may lead to dysfunctional sleep patterns.
AB - BACKGROUND: This study compares the sleep architecture of patients with posttraumatic stress disorder (PTSD) with that of both patients with depression and subjects with no mental disorder.METHOD: 45 German armed forces personnel with PTSD, 72 German armed forces personnel with depression and 24 healthy control subjects underwent 24-hour polysomnography. The effects of group membership, medication and the statistical interaction of group and medication were analysed for the following variables: sleep onset latency, REM sleep latency, slow-wave sleep and REM sleep percentages.RESULTS: Sleep onset latency was significantly prolonged in both the PTSD and the depression group. Moreover, psychotropic medication was associated with significantly prolonged REM sleep latency.CONCLUSION: The impact on sleep onset latency is of special clinical relevance in that according to preliminary studies, it is of major importance for subjective sleep quality. In contrast to the other parameters, an increase in sleep onset latency results in a subjective reduction in sleep quality which can lead to hyperarousal and increased preoccupation with sleep, which in turn may lead to dysfunctional sleep patterns.
KW - Adult
KW - Depressive Disorder/physiopathology
KW - Female
KW - Germany
KW - Humans
KW - Male
KW - Middle Aged
KW - Military Personnel
KW - Polysomnography
KW - Sleep Wake Disorders/physiopathology
KW - Sleep, REM
KW - Stress Disorders, Post-Traumatic/physiopathology
U2 - 10.1371/journal.pone.0215355
DO - 10.1371/journal.pone.0215355
M3 - SCORING: Journal article
C2 - 30995285
VL - 14
SP - e0215355
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 4
ER -
