cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space
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cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space. / Lamothe-Molina, Paul J.; Franzelin, Andreas; Auksutat, Lea; Laprell, Laura; Ahlbeck, Joachim; Kneussel, Matthias; Engel, Andreas K.; Morellini, Fabio; Oertner, Thomas G.
US Staat New York : Cold Spring Harbor Laboratory Press. 2020.Research output: Other contribution › Other › Research
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T1 - cFos ensembles in the dentate gyrus rapidly segregate over time and do not form a stable map of space
AU - Lamothe-Molina, Paul J.
AU - Franzelin, Andreas
AU - Auksutat, Lea
AU - Laprell, Laura
AU - Ahlbeck, Joachim
AU - Kneussel, Matthias
AU - Engel, Andreas K.
AU - Morellini, Fabio
AU - Oertner, Thomas G.
PY - 2020/8/31
Y1 - 2020/8/31
N2 - Mice require several days of training to master the water maze, a spatial memory task for rodents. The hippocampus plays a key role in the formation of spatial and episodic memories, a process that involves the activation of immediate-early genes such as cFos. We trained cFos-reporter mice in the water maze, expecting that consistent spatial behavior would be reflected by consistent cFos patterns across training episodes. Even after extensive training, however, different sets of dentate gyrus (DG) granule cells were activated every day. Suppressing activity in the original encoding ensemble helped mice to learn a novel platform position (reversal learning). Our results suggest that even in a constant environment, cFos+ ensembles in the dorsal DG segregate as a function of time, but become partially reactivated when animals try to access memories of past events.
AB - Mice require several days of training to master the water maze, a spatial memory task for rodents. The hippocampus plays a key role in the formation of spatial and episodic memories, a process that involves the activation of immediate-early genes such as cFos. We trained cFos-reporter mice in the water maze, expecting that consistent spatial behavior would be reflected by consistent cFos patterns across training episodes. Even after extensive training, however, different sets of dentate gyrus (DG) granule cells were activated every day. Suppressing activity in the original encoding ensemble helped mice to learn a novel platform position (reversal learning). Our results suggest that even in a constant environment, cFos+ ensembles in the dorsal DG segregate as a function of time, but become partially reactivated when animals try to access memories of past events.
UR - https://doi.org/10.1101/2020.08.29.273391
U2 - 10.1101/2020.08.29.273391
DO - 10.1101/2020.08.29.273391
M3 - Other
SN - 0-387-95457-0
VL - bioRxiv
PB - Cold Spring Harbor Laboratory Press
CY - US Staat New York
ER -
