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Cerebral Hypoperfusion Intensity Ratio Is Linked to Progressive Early Edema Formation

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Cerebral Hypoperfusion Intensity Ratio Is Linked to Progressive Early Edema Formation. / van Horn, Noel; Broocks, Gabriel; Kabiri, Reza; Kraemer, Michel C; Christensen, Soren; Mlynash, Michael; Meyer, Lukas; Lansberg, Maarten G; Albers, Gregory W; Sporns, Peter; Guenego, Adrien; Fiehler, Jens; Wintermark, Max; Heit, Jeremy J; Faizy, Tobias D.

In: J CLIN MED, Vol. 11, No. 9, 2373, 23.04.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

van Horn, N, Broocks, G, Kabiri, R, Kraemer, MC, Christensen, S, Mlynash, M, Meyer, L, Lansberg, MG, Albers, GW, Sporns, P, Guenego, A, Fiehler, J, Wintermark, M, Heit, JJ & Faizy, TD 2022, 'Cerebral Hypoperfusion Intensity Ratio Is Linked to Progressive Early Edema Formation', J CLIN MED, vol. 11, no. 9, 2373. https://doi.org/10.3390/jcm11092373

APA

van Horn, N., Broocks, G., Kabiri, R., Kraemer, M. C., Christensen, S., Mlynash, M., Meyer, L., Lansberg, M. G., Albers, G. W., Sporns, P., Guenego, A., Fiehler, J., Wintermark, M., Heit, J. J., & Faizy, T. D. (2022). Cerebral Hypoperfusion Intensity Ratio Is Linked to Progressive Early Edema Formation. J CLIN MED, 11(9), [2373]. https://doi.org/10.3390/jcm11092373

Vancouver

van Horn N, Broocks G, Kabiri R, Kraemer MC, Christensen S, Mlynash M et al. Cerebral Hypoperfusion Intensity Ratio Is Linked to Progressive Early Edema Formation. J CLIN MED. 2022 Apr 23;11(9). 2373. https://doi.org/10.3390/jcm11092373

Bibtex

@article{62bea67941ba46fda3227cfc9c2d75ad,
title = "Cerebral Hypoperfusion Intensity Ratio Is Linked to Progressive Early Edema Formation",
abstract = "The hypoperfusion intensity ratio (HIR) is associated with collateral status and reflects the impaired microperfusion of brain tissue in patients with acute ischemic stroke and large vessel occlusion (AIS-LVO). As a deterioration in cerebral blood flow is associated with brain edema, we aimed to investigate whether HIR is correlated with the early edema progression rate (EPR) determined by the ischemic net water uptake (NWU) in a multicenter retrospective analysis of AIS-LVO patients anticipated for thrombectomy treatment. HIR was automatically calculated as the ratio of time-to-maximum (TMax) > 10 s/(TMax) > 6 s. HIRs < 0.4 were regarded as favorable (HIR+) and ≥0.4 as unfavorable (HIR−). Quantitative ischemic lesion NWU was delineated on baseline NCCT images and EPR was calculated as the ratio of NWU/time from symptom onset to imaging. Multivariable regression analysis was used to assess the association of HIR with EPR. This study included 731 patients. HIR+ patients exhibited a reduced median NWU upon admission CT (4% (IQR: 2.1−7.6) versus 8.2% (6−10.4); p < 0.001) and less median EPR (0.016%/h (IQR: 0.007−0.04) versus 0.044%/h (IQR: 0.021−0.089; p < 0.001) compared to HIR− patients. Multivariable regression showed that HIR+ (β: 0.53, SE: 0.02; p = 0.003) and presentation of the National Institutes of Health Stroke Scale (β: 0.2, SE: 0.0006; p = 0.001) were independently associated with EPR. In conclusion, favorable HIR was associated with lower early edema progression and decreased ischemic edema formation on baseline NCCT.",
author = "{van Horn}, Noel and Gabriel Broocks and Reza Kabiri and Kraemer, {Michel C} and Soren Christensen and Michael Mlynash and Lukas Meyer and Lansberg, {Maarten G} and Albers, {Gregory W} and Peter Sporns and Adrien Guenego and Jens Fiehler and Max Wintermark and Heit, {Jeremy J} and Faizy, {Tobias D}",
year = "2022",
month = apr,
day = "23",
doi = "10.3390/jcm11092373",
language = "English",
volume = "11",
journal = "J CLIN MED",
issn = "2077-0383",
publisher = "MDPI AG",
number = "9",

}

RIS

TY - JOUR

T1 - Cerebral Hypoperfusion Intensity Ratio Is Linked to Progressive Early Edema Formation

AU - van Horn, Noel

AU - Broocks, Gabriel

AU - Kabiri, Reza

AU - Kraemer, Michel C

AU - Christensen, Soren

AU - Mlynash, Michael

AU - Meyer, Lukas

AU - Lansberg, Maarten G

AU - Albers, Gregory W

AU - Sporns, Peter

AU - Guenego, Adrien

AU - Fiehler, Jens

AU - Wintermark, Max

AU - Heit, Jeremy J

AU - Faizy, Tobias D

PY - 2022/4/23

Y1 - 2022/4/23

N2 - The hypoperfusion intensity ratio (HIR) is associated with collateral status and reflects the impaired microperfusion of brain tissue in patients with acute ischemic stroke and large vessel occlusion (AIS-LVO). As a deterioration in cerebral blood flow is associated with brain edema, we aimed to investigate whether HIR is correlated with the early edema progression rate (EPR) determined by the ischemic net water uptake (NWU) in a multicenter retrospective analysis of AIS-LVO patients anticipated for thrombectomy treatment. HIR was automatically calculated as the ratio of time-to-maximum (TMax) > 10 s/(TMax) > 6 s. HIRs < 0.4 were regarded as favorable (HIR+) and ≥0.4 as unfavorable (HIR−). Quantitative ischemic lesion NWU was delineated on baseline NCCT images and EPR was calculated as the ratio of NWU/time from symptom onset to imaging. Multivariable regression analysis was used to assess the association of HIR with EPR. This study included 731 patients. HIR+ patients exhibited a reduced median NWU upon admission CT (4% (IQR: 2.1−7.6) versus 8.2% (6−10.4); p < 0.001) and less median EPR (0.016%/h (IQR: 0.007−0.04) versus 0.044%/h (IQR: 0.021−0.089; p < 0.001) compared to HIR− patients. Multivariable regression showed that HIR+ (β: 0.53, SE: 0.02; p = 0.003) and presentation of the National Institutes of Health Stroke Scale (β: 0.2, SE: 0.0006; p = 0.001) were independently associated with EPR. In conclusion, favorable HIR was associated with lower early edema progression and decreased ischemic edema formation on baseline NCCT.

AB - The hypoperfusion intensity ratio (HIR) is associated with collateral status and reflects the impaired microperfusion of brain tissue in patients with acute ischemic stroke and large vessel occlusion (AIS-LVO). As a deterioration in cerebral blood flow is associated with brain edema, we aimed to investigate whether HIR is correlated with the early edema progression rate (EPR) determined by the ischemic net water uptake (NWU) in a multicenter retrospective analysis of AIS-LVO patients anticipated for thrombectomy treatment. HIR was automatically calculated as the ratio of time-to-maximum (TMax) > 10 s/(TMax) > 6 s. HIRs < 0.4 were regarded as favorable (HIR+) and ≥0.4 as unfavorable (HIR−). Quantitative ischemic lesion NWU was delineated on baseline NCCT images and EPR was calculated as the ratio of NWU/time from symptom onset to imaging. Multivariable regression analysis was used to assess the association of HIR with EPR. This study included 731 patients. HIR+ patients exhibited a reduced median NWU upon admission CT (4% (IQR: 2.1−7.6) versus 8.2% (6−10.4); p < 0.001) and less median EPR (0.016%/h (IQR: 0.007−0.04) versus 0.044%/h (IQR: 0.021−0.089; p < 0.001) compared to HIR− patients. Multivariable regression showed that HIR+ (β: 0.53, SE: 0.02; p = 0.003) and presentation of the National Institutes of Health Stroke Scale (β: 0.2, SE: 0.0006; p = 0.001) were independently associated with EPR. In conclusion, favorable HIR was associated with lower early edema progression and decreased ischemic edema formation on baseline NCCT.

U2 - 10.3390/jcm11092373

DO - 10.3390/jcm11092373

M3 - SCORING: Journal article

C2 - 35566500

VL - 11

JO - J CLIN MED

JF - J CLIN MED

SN - 2077-0383

IS - 9

M1 - 2373

ER -