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Cerebellar heterotopia of infancy in sudden infant death syndrome

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Cerebellar heterotopia of infancy in sudden infant death syndrome : an observational neuropathological study of four cases. / Matschke, Jakob; Sperhake, Jan-Peter; Wilke, Nadine; Püschel, Klaus; Glatzel, Markus.

In: INT J LEGAL MED, Vol. 134, No. 6, 11.2020, p. 2143-2147.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Matschke, J, Sperhake, J-P, Wilke, N, Püschel, K & Glatzel, M 2020, 'Cerebellar heterotopia of infancy in sudden infant death syndrome: an observational neuropathological study of four cases', INT J LEGAL MED, vol. 134, no. 6, pp. 2143-2147. https://doi.org/10.1007/s00414-020-02316-x

APA

Matschke, J., Sperhake, J-P., Wilke, N., Püschel, K., & Glatzel, M. (2020). Cerebellar heterotopia of infancy in sudden infant death syndrome: an observational neuropathological study of four cases. INT J LEGAL MED, 134(6), 2143-2147. https://doi.org/10.1007/s00414-020-02316-x

Vancouver

Matschke J, Sperhake J-P, Wilke N, Püschel K, Glatzel M. Cerebellar heterotopia of infancy in sudden infant death syndrome: an observational neuropathological study of four cases. INT J LEGAL MED. 2020 Nov;134(6):2143-2147. https://doi.org/10.1007/s00414-020-02316-x

Bibtex

@article{c37ac6947afb4ba1990bdbb0dd2f2d77,
title = "Cerebellar heterotopia of infancy in sudden infant death syndrome: an observational neuropathological study of four cases",
abstract = "Sudden infant death syndrome (SIDS) is the sudden unexpected death of an infant < 1 year of age that remains unexplained after comprehensive workup including complete autopsy and investigation of the circumstances of death. The triple risk hypothesis posits that SIDS results as a combination of both intrinsic and extrinsic factors on the background of a predisposing vulnerability. Neuropathological examination in the past has focussed mainly on the brainstem as the major player in respiratory control, where subtle findings have been linked to the chain of events leading to death in SIDS. The cerebellum has received less attention, probably due to an assumed negligible role in central cardiorespiratory control. We report four cases of SIDS in which neuropathological investigation revealed cerebellar heterotopia of infancy, a distinct malformation of the cerebellum, and discuss the potential impact of this condition on the aetiology and pathogenesis of SIDS.",
author = "Jakob Matschke and Jan-Peter Sperhake and Nadine Wilke and Klaus P{\"u}schel and Markus Glatzel",
year = "2020",
month = nov,
doi = "10.1007/s00414-020-02316-x",
language = "English",
volume = "134",
pages = "2143--2147",
journal = "INT J LEGAL MED",
issn = "0937-9827",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Cerebellar heterotopia of infancy in sudden infant death syndrome

T2 - an observational neuropathological study of four cases

AU - Matschke, Jakob

AU - Sperhake, Jan-Peter

AU - Wilke, Nadine

AU - Püschel, Klaus

AU - Glatzel, Markus

PY - 2020/11

Y1 - 2020/11

N2 - Sudden infant death syndrome (SIDS) is the sudden unexpected death of an infant < 1 year of age that remains unexplained after comprehensive workup including complete autopsy and investigation of the circumstances of death. The triple risk hypothesis posits that SIDS results as a combination of both intrinsic and extrinsic factors on the background of a predisposing vulnerability. Neuropathological examination in the past has focussed mainly on the brainstem as the major player in respiratory control, where subtle findings have been linked to the chain of events leading to death in SIDS. The cerebellum has received less attention, probably due to an assumed negligible role in central cardiorespiratory control. We report four cases of SIDS in which neuropathological investigation revealed cerebellar heterotopia of infancy, a distinct malformation of the cerebellum, and discuss the potential impact of this condition on the aetiology and pathogenesis of SIDS.

AB - Sudden infant death syndrome (SIDS) is the sudden unexpected death of an infant < 1 year of age that remains unexplained after comprehensive workup including complete autopsy and investigation of the circumstances of death. The triple risk hypothesis posits that SIDS results as a combination of both intrinsic and extrinsic factors on the background of a predisposing vulnerability. Neuropathological examination in the past has focussed mainly on the brainstem as the major player in respiratory control, where subtle findings have been linked to the chain of events leading to death in SIDS. The cerebellum has received less attention, probably due to an assumed negligible role in central cardiorespiratory control. We report four cases of SIDS in which neuropathological investigation revealed cerebellar heterotopia of infancy, a distinct malformation of the cerebellum, and discuss the potential impact of this condition on the aetiology and pathogenesis of SIDS.

U2 - 10.1007/s00414-020-02316-x

DO - 10.1007/s00414-020-02316-x

M3 - SCORING: Journal article

C2 - 32435901

VL - 134

SP - 2143

EP - 2147

JO - INT J LEGAL MED

JF - INT J LEGAL MED

SN - 0937-9827

IS - 6

ER -