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Central and peripheral administration of atriopeptin is anxiolytic in rats.

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Central and peripheral administration of atriopeptin is anxiolytic in rats. / Ströhle, A; Jahn, Holger; Montkowski, A; Liebsch, G; Boll, E; Landgraf, R; Holsboer, F; Wiedemann, Klaus.

In: NEUROENDOCRINOLOGY, Vol. 65, No. 3, 3, 1997, p. 210-215.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ströhle, A, Jahn, H, Montkowski, A, Liebsch, G, Boll, E, Landgraf, R, Holsboer, F & Wiedemann, K 1997, 'Central and peripheral administration of atriopeptin is anxiolytic in rats.', NEUROENDOCRINOLOGY, vol. 65, no. 3, 3, pp. 210-215. <http://www.ncbi.nlm.nih.gov/pubmed/9088002?dopt=Citation>

APA

Ströhle, A., Jahn, H., Montkowski, A., Liebsch, G., Boll, E., Landgraf, R., Holsboer, F., & Wiedemann, K. (1997). Central and peripheral administration of atriopeptin is anxiolytic in rats. NEUROENDOCRINOLOGY, 65(3), 210-215. [3]. http://www.ncbi.nlm.nih.gov/pubmed/9088002?dopt=Citation

Vancouver

Ströhle A, Jahn H, Montkowski A, Liebsch G, Boll E, Landgraf R et al. Central and peripheral administration of atriopeptin is anxiolytic in rats. NEUROENDOCRINOLOGY. 1997;65(3):210-215. 3.

Bibtex

@article{5f15b31d0b70461981e6cd304f3cf198,
title = "Central and peripheral administration of atriopeptin is anxiolytic in rats.",
abstract = "The effects of the central and peripheral administration of atriopeptin II, a 23-amino acid residue peptide of atrial natriuretic peptide (Ser103-Arg125) on anxiety-related behavior and on locomotor activity, was studied in male Wistar rats. Their behavior on the elevated plus-maze after social defeat stress indicated that intracerebroventricular (2.5 and 5 micrograms) and intraperitoneal (50 micrograms) administration of atriopeptin II produced anxiolysis. A low dose of 0.25 micrograms atriopeptin II administered bilaterally into the central nucleus of the amygdala was also found to be anxiolytic. Because intracerebroventricular administration of 5 micrograms atriopeptin II did not affect locomotor activity in the open-field test, the possibility that the anxiolytic effect was secondary to sedation could be ruled out. The anxiolytic effects observed after central and peripheral administration support the idea that atrial natriuretic peptide, which is increased in panic-anxiety, may be involved in the tapering of anxiety-related behavior.",
author = "A Str{\"o}hle and Holger Jahn and A Montkowski and G Liebsch and E Boll and R Landgraf and F Holsboer and Klaus Wiedemann",
year = "1997",
language = "Deutsch",
volume = "65",
pages = "210--215",
journal = "NEUROENDOCRINOLOGY",
issn = "0028-3835",
publisher = "S. Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Central and peripheral administration of atriopeptin is anxiolytic in rats.

AU - Ströhle, A

AU - Jahn, Holger

AU - Montkowski, A

AU - Liebsch, G

AU - Boll, E

AU - Landgraf, R

AU - Holsboer, F

AU - Wiedemann, Klaus

PY - 1997

Y1 - 1997

N2 - The effects of the central and peripheral administration of atriopeptin II, a 23-amino acid residue peptide of atrial natriuretic peptide (Ser103-Arg125) on anxiety-related behavior and on locomotor activity, was studied in male Wistar rats. Their behavior on the elevated plus-maze after social defeat stress indicated that intracerebroventricular (2.5 and 5 micrograms) and intraperitoneal (50 micrograms) administration of atriopeptin II produced anxiolysis. A low dose of 0.25 micrograms atriopeptin II administered bilaterally into the central nucleus of the amygdala was also found to be anxiolytic. Because intracerebroventricular administration of 5 micrograms atriopeptin II did not affect locomotor activity in the open-field test, the possibility that the anxiolytic effect was secondary to sedation could be ruled out. The anxiolytic effects observed after central and peripheral administration support the idea that atrial natriuretic peptide, which is increased in panic-anxiety, may be involved in the tapering of anxiety-related behavior.

AB - The effects of the central and peripheral administration of atriopeptin II, a 23-amino acid residue peptide of atrial natriuretic peptide (Ser103-Arg125) on anxiety-related behavior and on locomotor activity, was studied in male Wistar rats. Their behavior on the elevated plus-maze after social defeat stress indicated that intracerebroventricular (2.5 and 5 micrograms) and intraperitoneal (50 micrograms) administration of atriopeptin II produced anxiolysis. A low dose of 0.25 micrograms atriopeptin II administered bilaterally into the central nucleus of the amygdala was also found to be anxiolytic. Because intracerebroventricular administration of 5 micrograms atriopeptin II did not affect locomotor activity in the open-field test, the possibility that the anxiolytic effect was secondary to sedation could be ruled out. The anxiolytic effects observed after central and peripheral administration support the idea that atrial natriuretic peptide, which is increased in panic-anxiety, may be involved in the tapering of anxiety-related behavior.

M3 - SCORING: Zeitschriftenaufsatz

VL - 65

SP - 210

EP - 215

JO - NEUROENDOCRINOLOGY

JF - NEUROENDOCRINOLOGY

SN - 0028-3835

IS - 3

M1 - 3

ER -