Research ExplorerPublicationsCellular immune reconstitution after haploidentical transpla...

Cellular immune reconstitution after haploidentical transplantation in children

Standard

Cellular immune reconstitution after haploidentical transplantation in children. / Handgretinger, R; Chen, X; Pfeiffer, M; Schumm, M; Müller, Ingo; Feuchtinger, T; Hale, G; Lang, P.

In: BIOL BLOOD MARROW TR, Vol. 14, No. 1 Suppl 1, 01.2008, p. 59-65.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Handgretinger, R, Chen, X, Pfeiffer, M, Schumm, M, Müller, I, Feuchtinger, T, Hale, G & Lang, P 2008, 'Cellular immune reconstitution after haploidentical transplantation in children', BIOL BLOOD MARROW TR, vol. 14, no. 1 Suppl 1, pp. 59-65. https://doi.org/10.1016/j.bbmt.2007.10.015

APA

Handgretinger, R., Chen, X., Pfeiffer, M., Schumm, M., Müller, I., Feuchtinger, T., Hale, G., & Lang, P. (2008). Cellular immune reconstitution after haploidentical transplantation in children. BIOL BLOOD MARROW TR, 14(1 Suppl 1), 59-65. https://doi.org/10.1016/j.bbmt.2007.10.015

Vancouver

Handgretinger R, Chen X, Pfeiffer M, Schumm M, Müller I, Feuchtinger T et al. Cellular immune reconstitution after haploidentical transplantation in children. BIOL BLOOD MARROW TR. 2008 Jan;14(1 Suppl 1):59-65. https://doi.org/10.1016/j.bbmt.2007.10.015

Bibtex

@article{988b08ccdbcc4139a011ac4308f799af,
title = "Cellular immune reconstitution after haploidentical transplantation in children",
abstract = "Delayed immune reconstitution is 1 of the major contributions to the morbidity and mortality after haploidentical transplantation. Patients with a slow recovery of the innate and especially of the adaptive immune system are at high risk for severe and often lethal infections. The reason for delayed immune reconstitution after haploidentical transplantation include the T cell depletion (TCD) of the graft, the thymic dysfunction induced by pretransplant chemotherapies and by the conditioning regimens, and the occurrence of graft-versus-host disease (GVHD) and its treatment. The detailed analysis, understanding, and manipulation of the reconstitution of the cellular immune system will be of utmost importance to overcome the posttransplant immunodefcient status, and should result in a reduced risk of severe and overwhelming infections and hopefully also to a reduced risk of relapse through better immunological control of residual malignant cells.",
keywords = "Child, Haplotypes, Hematopoietic Stem Cell Transplantation, Humans, Immunity, Cellular, Killer Cells, Natural, Lymphocyte Depletion, Regeneration",
author = "R Handgretinger and X Chen and M Pfeiffer and M Schumm and Ingo M{\"u}ller and T Feuchtinger and G Hale and P Lang",
year = "2008",
month = jan,
doi = "10.1016/j.bbmt.2007.10.015",
language = "English",
volume = "14",
pages = "59--65",
journal = "BIOL BLOOD MARROW TR",
issn = "1083-8791",
publisher = "Elsevier Inc.",
number = "1 Suppl 1",

}

RIS

TY - JOUR

T1 - Cellular immune reconstitution after haploidentical transplantation in children

AU - Handgretinger, R

AU - Chen, X

AU - Pfeiffer, M

AU - Schumm, M

AU - Müller, Ingo

AU - Feuchtinger, T

AU - Hale, G

AU - Lang, P

PY - 2008/1

Y1 - 2008/1

N2 - Delayed immune reconstitution is 1 of the major contributions to the morbidity and mortality after haploidentical transplantation. Patients with a slow recovery of the innate and especially of the adaptive immune system are at high risk for severe and often lethal infections. The reason for delayed immune reconstitution after haploidentical transplantation include the T cell depletion (TCD) of the graft, the thymic dysfunction induced by pretransplant chemotherapies and by the conditioning regimens, and the occurrence of graft-versus-host disease (GVHD) and its treatment. The detailed analysis, understanding, and manipulation of the reconstitution of the cellular immune system will be of utmost importance to overcome the posttransplant immunodefcient status, and should result in a reduced risk of severe and overwhelming infections and hopefully also to a reduced risk of relapse through better immunological control of residual malignant cells.

AB - Delayed immune reconstitution is 1 of the major contributions to the morbidity and mortality after haploidentical transplantation. Patients with a slow recovery of the innate and especially of the adaptive immune system are at high risk for severe and often lethal infections. The reason for delayed immune reconstitution after haploidentical transplantation include the T cell depletion (TCD) of the graft, the thymic dysfunction induced by pretransplant chemotherapies and by the conditioning regimens, and the occurrence of graft-versus-host disease (GVHD) and its treatment. The detailed analysis, understanding, and manipulation of the reconstitution of the cellular immune system will be of utmost importance to overcome the posttransplant immunodefcient status, and should result in a reduced risk of severe and overwhelming infections and hopefully also to a reduced risk of relapse through better immunological control of residual malignant cells.

KW - Child

KW - Haplotypes

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Immunity, Cellular

KW - Killer Cells, Natural

KW - Lymphocyte Depletion

KW - Regeneration

U2 - 10.1016/j.bbmt.2007.10.015

DO - 10.1016/j.bbmt.2007.10.015

M3 - SCORING: Journal article

C2 - 18162222

VL - 14

SP - 59

EP - 65

JO - BIOL BLOOD MARROW TR

JF - BIOL BLOOD MARROW TR

SN - 1083-8791

IS - 1 Suppl 1

ER -