Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia.
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Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia. / Kaaijk, P; Kaspers, G J L; Van Wering, E R; Broekema, G J; Loonen, A H; Hählen, K; Schmiegelow, K; Janka-Schaub, Gritta; Henze, G; Creutzig, U; Veerman, A J P.
In: BRIT J CANCER, Vol. 88, No. 5, 5, 2003, p. 775-781.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia.
AU - Kaaijk, P
AU - Kaspers, G J L
AU - Van Wering, E R
AU - Broekema, G J
AU - Loonen, A H
AU - Hählen, K
AU - Schmiegelow, K
AU - Janka-Schaub, Gritta
AU - Henze, G
AU - Creutzig, U
AU - Veerman, A J P
PY - 2003
Y1 - 2003
N2 - Bone marrow and peripheral blood samples from 362 patients with acute lymphoblastic leukaemia (ALL) proliferating cell and 90 patients with acute myeloid leukaemia (AML) were analysed for S-phase fractions, Ki67 antigen, and proliferating cell nuclear antigen expression. The S-phase fractions were correlated with in vitro drug resistance to 15 different anticancer agents. Leukaemia cells isolated from bone marrow had higher S-phase fractions than leukaemia cells isolated from peripheral blood (in initial ALL, median values resp. 6.9 and 2.7%, in initial AML resp. 5.3 and 1.3%; both P
AB - Bone marrow and peripheral blood samples from 362 patients with acute lymphoblastic leukaemia (ALL) proliferating cell and 90 patients with acute myeloid leukaemia (AML) were analysed for S-phase fractions, Ki67 antigen, and proliferating cell nuclear antigen expression. The S-phase fractions were correlated with in vitro drug resistance to 15 different anticancer agents. Leukaemia cells isolated from bone marrow had higher S-phase fractions than leukaemia cells isolated from peripheral blood (in initial ALL, median values resp. 6.9 and 2.7%, in initial AML resp. 5.3 and 1.3%; both P
M3 - SCORING: Zeitschriftenaufsatz
VL - 88
SP - 775
EP - 781
JO - BRIT J CANCER
JF - BRIT J CANCER
SN - 0007-0920
IS - 5
M1 - 5
ER -