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Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas.

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Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas. / Fillies, Thomas; Woltering, Mike; Brandt, Burkhard; Jean-Paul, Van Diest; Werkmeister, Richard; Joos, Ulrich; Buerger, Horst.

In: ONCOL REP, Vol. 17, No. 2, 2, 2007, p. 355-359.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fillies, T, Woltering, M, Brandt, B, Jean-Paul, VD, Werkmeister, R, Joos, U & Buerger, H 2007, 'Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas.', ONCOL REP, vol. 17, no. 2, 2, pp. 355-359. <http://www.ncbi.nlm.nih.gov/pubmed/17203174?dopt=Citation>

APA

Fillies, T., Woltering, M., Brandt, B., Jean-Paul, V. D., Werkmeister, R., Joos, U., & Buerger, H. (2007). Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas. ONCOL REP, 17(2), 355-359. [2]. http://www.ncbi.nlm.nih.gov/pubmed/17203174?dopt=Citation

Vancouver

Fillies T, Woltering M, Brandt B, Jean-Paul VD, Werkmeister R, Joos U et al. Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas. ONCOL REP. 2007;17(2):355-359. 2.

Bibtex

@article{865659480f5d4ea9b07b4984dbebbddd,
title = "Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas.",
abstract = "Cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CDKIs), such as p21 and p27, exert a direct control on the cell cycle. p21 and p27 are negative regulators of cyclin-dependent kinases and in this function they are negative check-point regulators of the cell cycle. We therefore aimed to evaluate p21 and p27 expression in oral squamous cell carcinomas (OSSC) to determine the value as a prognostic marker. One hundred and ninety-two patients with histologically proven, surgically treated squamous cell carcinoma of the oral cavity were eligible for the study and investigated for the expression of p21 and p27 by means of tissue microarrays (TMAs). Immunohistochemical screening under identical condition were carried out with antibodies against p21 and p27. Correlations between clinical features and the expression of the respective antibodies were evaluated statistically by Kaplan-Meier curves, log-rank and chi(2) tests. The expression of p21 correlated significantly with an increased prognosis in the log-rang test (p=0.01). No significant correlation was found between the expression of p27 and the overall survival rate. In multivariate Cox analysis, p27 was indicated as independent predictor of survival prognosis in the subgroup of nodal positive carcinomas, p27 positive tumours showed a significantly better survival prognosis (p=0.03). p21 and p27 in carcinoma of oral cavity seem to be predictive parameter in regulation and prognosis of squamous cell carcinomas. A p21 negative subgroup of OSCC may benefit from additional radio or radiochemotherapy.",
author = "Thomas Fillies and Mike Woltering and Burkhard Brandt and Jean-Paul, {Van Diest} and Richard Werkmeister and Ulrich Joos and Horst Buerger",
year = "2007",
language = "Deutsch",
volume = "17",
pages = "355--359",
journal = "ONCOL REP",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "2",

}

RIS

TY - JOUR

T1 - Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas.

AU - Fillies, Thomas

AU - Woltering, Mike

AU - Brandt, Burkhard

AU - Jean-Paul, Van Diest

AU - Werkmeister, Richard

AU - Joos, Ulrich

AU - Buerger, Horst

PY - 2007

Y1 - 2007

N2 - Cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CDKIs), such as p21 and p27, exert a direct control on the cell cycle. p21 and p27 are negative regulators of cyclin-dependent kinases and in this function they are negative check-point regulators of the cell cycle. We therefore aimed to evaluate p21 and p27 expression in oral squamous cell carcinomas (OSSC) to determine the value as a prognostic marker. One hundred and ninety-two patients with histologically proven, surgically treated squamous cell carcinoma of the oral cavity were eligible for the study and investigated for the expression of p21 and p27 by means of tissue microarrays (TMAs). Immunohistochemical screening under identical condition were carried out with antibodies against p21 and p27. Correlations between clinical features and the expression of the respective antibodies were evaluated statistically by Kaplan-Meier curves, log-rank and chi(2) tests. The expression of p21 correlated significantly with an increased prognosis in the log-rang test (p=0.01). No significant correlation was found between the expression of p27 and the overall survival rate. In multivariate Cox analysis, p27 was indicated as independent predictor of survival prognosis in the subgroup of nodal positive carcinomas, p27 positive tumours showed a significantly better survival prognosis (p=0.03). p21 and p27 in carcinoma of oral cavity seem to be predictive parameter in regulation and prognosis of squamous cell carcinomas. A p21 negative subgroup of OSCC may benefit from additional radio or radiochemotherapy.

AB - Cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CDKIs), such as p21 and p27, exert a direct control on the cell cycle. p21 and p27 are negative regulators of cyclin-dependent kinases and in this function they are negative check-point regulators of the cell cycle. We therefore aimed to evaluate p21 and p27 expression in oral squamous cell carcinomas (OSSC) to determine the value as a prognostic marker. One hundred and ninety-two patients with histologically proven, surgically treated squamous cell carcinoma of the oral cavity were eligible for the study and investigated for the expression of p21 and p27 by means of tissue microarrays (TMAs). Immunohistochemical screening under identical condition were carried out with antibodies against p21 and p27. Correlations between clinical features and the expression of the respective antibodies were evaluated statistically by Kaplan-Meier curves, log-rank and chi(2) tests. The expression of p21 correlated significantly with an increased prognosis in the log-rang test (p=0.01). No significant correlation was found between the expression of p27 and the overall survival rate. In multivariate Cox analysis, p27 was indicated as independent predictor of survival prognosis in the subgroup of nodal positive carcinomas, p27 positive tumours showed a significantly better survival prognosis (p=0.03). p21 and p27 in carcinoma of oral cavity seem to be predictive parameter in regulation and prognosis of squamous cell carcinomas. A p21 negative subgroup of OSCC may benefit from additional radio or radiochemotherapy.

M3 - SCORING: Zeitschriftenaufsatz

VL - 17

SP - 355

EP - 359

JO - ONCOL REP

JF - ONCOL REP

SN - 1021-335X

IS - 2

M1 - 2

ER -