CD83 is a regulator of murine B cell function in vivo.
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CD83 is a regulator of murine B cell function in vivo. / Breloer, Minka; Kretschmer, Birte; Lüthje, Katja; Ehrlich, Svenja; Ritter, Uwe; Bickert, Thomas; Steeg, Christiane; Fillatreau, Simon; Hoehlig, Kai; Lampropoulou, Vassiliki; Fleischer, Bernhard.
In: EUR J IMMUNOL, Vol. 37, No. 3, 3, 2007, p. 634-648.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - CD83 is a regulator of murine B cell function in vivo.
AU - Breloer, Minka
AU - Kretschmer, Birte
AU - Lüthje, Katja
AU - Ehrlich, Svenja
AU - Ritter, Uwe
AU - Bickert, Thomas
AU - Steeg, Christiane
AU - Fillatreau, Simon
AU - Hoehlig, Kai
AU - Lampropoulou, Vassiliki
AU - Fleischer, Bernhard
PY - 2007
Y1 - 2007
N2 - The transmembrane glycoprotein CD83 has been described as a specific maturation marker for dendritic cells and several lines of evidence suggest that CD83 regulates thymic T cell maturation as well as peripheral T cell activation. Here we show for the first time that CD83 is involved also in the regulation of B cell function. CD83 is up-regulated on activated B cells in vivo, specifically in the draining lymph nodes of Leishmania major-infected mice. The ubiquitous transgenic (Tg) expression of CD83 interferes with Leishmania-specific T cell-dependent and with T cell-independent antibody production. This defect is restricted to the B cell population since the antigen-specific T cell response of CD83Tg mice to L. major infection is unchanged. The defective immunoglobulin (Ig) response is due to Tg expression of CD83 on the B cells because wild-type B cells display normal antigen-specific responses in CD83Tg hosts and CD83Tg B cells do not respond to immunization in a mixed wild-type/CD83Tg bone marrow chimera. Finally, the treatment of non-Tg C57BL/6 mice with anti-CD83 mAb induces a dramatic increase in the antigen-specific IgG response to immunization, thus demonstrating a regulatory role for naturally induced CD83 on wild-type B cells.
AB - The transmembrane glycoprotein CD83 has been described as a specific maturation marker for dendritic cells and several lines of evidence suggest that CD83 regulates thymic T cell maturation as well as peripheral T cell activation. Here we show for the first time that CD83 is involved also in the regulation of B cell function. CD83 is up-regulated on activated B cells in vivo, specifically in the draining lymph nodes of Leishmania major-infected mice. The ubiquitous transgenic (Tg) expression of CD83 interferes with Leishmania-specific T cell-dependent and with T cell-independent antibody production. This defect is restricted to the B cell population since the antigen-specific T cell response of CD83Tg mice to L. major infection is unchanged. The defective immunoglobulin (Ig) response is due to Tg expression of CD83 on the B cells because wild-type B cells display normal antigen-specific responses in CD83Tg hosts and CD83Tg B cells do not respond to immunization in a mixed wild-type/CD83Tg bone marrow chimera. Finally, the treatment of non-Tg C57BL/6 mice with anti-CD83 mAb induces a dramatic increase in the antigen-specific IgG response to immunization, thus demonstrating a regulatory role for naturally induced CD83 on wild-type B cells.
M3 - SCORING: Zeitschriftenaufsatz
VL - 37
SP - 634
EP - 648
JO - EUR J IMMUNOL
JF - EUR J IMMUNOL
SN - 0014-2980
IS - 3
M1 - 3
ER -
