CD44 expression and tumour cell density correlate with response to tamoxifen/carboplatin chemotherapy in glioblastomas
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CD44 expression and tumour cell density correlate with response to tamoxifen/carboplatin chemotherapy in glioblastomas. / Hagel, Christian; Park, Sung-Ho; Puchner, Maximilian J A; Stavrou, Dimitrios.
In: J NEURO-ONCOL, Vol. 66, No. 1-2, 01.2004, p. 139-46.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - CD44 expression and tumour cell density correlate with response to tamoxifen/carboplatin chemotherapy in glioblastomas
AU - Hagel, Christian
AU - Park, Sung-Ho
AU - Puchner, Maximilian J A
AU - Stavrou, Dimitrios
PY - 2004/1
Y1 - 2004/1
N2 - In order to identify response predictors for a post-operative glioblastoma therapy consisting of tamoxifen, carboplatin and radiotherapy, expression of 12 antigens was evaluated in 36 newly diagnosed tumours and 13 recurrences. Results were correlated with the clinical course of the disease. Antigen expression was assessed immunohistochemically for CD44s, TGF-beta2, TGF-alpha, progesterone receptor, estrogen receptor, EGFR, urokinase, urokinase inhibitor 1, CD87, p53 protein and Ki-67. Vessel density was determined by labelling of endothelia with von Willebrand factor. Response to chemotherapy correlated positively with cell density (p < 0.05) and negatively with CD44 over-expression (p < 0.02). Further, a positive correlation between age and CD44 expression (p < 0.05) and a negative correlation between age and p53 accumulation (p < 0.01) was found. In tumour recurrences expression of CD44 was significantly higher in local recurrences than in distant multifocal recurrences (p < 0.02), suggesting that CD44 may predominantly be associated with cell adhesion in glioblastomas.
AB - In order to identify response predictors for a post-operative glioblastoma therapy consisting of tamoxifen, carboplatin and radiotherapy, expression of 12 antigens was evaluated in 36 newly diagnosed tumours and 13 recurrences. Results were correlated with the clinical course of the disease. Antigen expression was assessed immunohistochemically for CD44s, TGF-beta2, TGF-alpha, progesterone receptor, estrogen receptor, EGFR, urokinase, urokinase inhibitor 1, CD87, p53 protein and Ki-67. Vessel density was determined by labelling of endothelia with von Willebrand factor. Response to chemotherapy correlated positively with cell density (p < 0.05) and negatively with CD44 over-expression (p < 0.02). Further, a positive correlation between age and CD44 expression (p < 0.05) and a negative correlation between age and p53 accumulation (p < 0.01) was found. In tumour recurrences expression of CD44 was significantly higher in local recurrences than in distant multifocal recurrences (p < 0.02), suggesting that CD44 may predominantly be associated with cell adhesion in glioblastomas.
KW - Adult
KW - Aged
KW - Antineoplastic Agents/administration & dosage
KW - Antineoplastic Agents, Hormonal/administration & dosage
KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
KW - Brain Neoplasms/drug therapy
KW - Carboplatin/administration & dosage
KW - Combined Modality Therapy
KW - Female
KW - Glioblastoma/drug therapy
KW - Humans
KW - Hyaluronan Receptors/metabolism
KW - Immunohistochemistry
KW - Male
KW - Middle Aged
KW - Neoplasm Recurrence, Local/drug therapy
KW - Neovascularization, Pathologic/metabolism
KW - Postoperative Care
KW - Tamoxifen/administration & dosage
KW - von Willebrand Factor/metabolism
U2 - 10.1023/b:neon.0000013496.58236.f0
DO - 10.1023/b:neon.0000013496.58236.f0
M3 - SCORING: Journal article
C2 - 15015779
VL - 66
SP - 139
EP - 146
JO - J NEURO-ONCOL
JF - J NEURO-ONCOL
SN - 0167-594X
IS - 1-2
ER -
