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CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis

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CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis. / Zhang, Tao; Wahib, Ramez; Zazara, Dimitra E; Lücke, Jöran; Shiri, Ahmad Mustafa; Kempski, Jan; Zhao, Lilan; Agalioti, Theodora; Machicote, Andres Pablo; Giannou, Olympia; Belios, Ioannis; Jia, Rongrong; Zhang, Siwen; Tintelnot, Joseph; Seese, Hannes; Grass, Julia Kristin; Mercanoglu, Baris; Stern, Louisa; Scognamiglio, Pasquale; Fard-Aghaie, Mohammad; Seeger, Philipp; Wakker, Jonas; Kemper, Marius; Brunswig, Benjamin; Duprée, Anna; Lykoudis, Panagis M; Pikouli, Anastasia; Giorgakis, Emmanouil; Stringa, Pablo; Lausada, Natalia; Gentilini, Maria Virginia; Gondolesi, Gabriel E; Bachmann, Kai; Busch, Philipp; Grotelüschen, Rainer; Maroulis, Ioannis C; Arck, Petra C; Nakano, Ryosuke; Thomson, Angus W; Ghadban, Tarik; Tachezy, Michael; Melling, Nathaniel; Achilles, Eike-Gert; Puelles, Victor G; Nickel, Felix; Hackert, Thilo; Mann, Oliver; Izbicki, Jakob R; Li, Jun; Gagliani, Nicola; Huber, Samuel; Giannou, Anastasios D.

In: ONCOIMMUNOLOGY, Vol. 12, No. 1, 2023, p. 2269634.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zhang, T, Wahib, R, Zazara, DE, Lücke, J, Shiri, AM, Kempski, J, Zhao, L, Agalioti, T, Machicote, AP, Giannou, O, Belios, I, Jia, R, Zhang, S, Tintelnot, J, Seese, H, Grass, JK, Mercanoglu, B, Stern, L, Scognamiglio, P, Fard-Aghaie, M, Seeger, P, Wakker, J, Kemper, M, Brunswig, B, Duprée, A, Lykoudis, PM, Pikouli, A, Giorgakis, E, Stringa, P, Lausada, N, Gentilini, MV, Gondolesi, GE, Bachmann, K, Busch, P, Grotelüschen, R, Maroulis, IC, Arck, PC, Nakano, R, Thomson, AW, Ghadban, T, Tachezy, M, Melling, N, Achilles, E-G, Puelles, VG, Nickel, F, Hackert, T, Mann, O, Izbicki, JR, Li, J, Gagliani, N, Huber, S & Giannou, AD 2023, 'CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis', ONCOIMMUNOLOGY, vol. 12, no. 1, pp. 2269634. https://doi.org/10.1080/2162402X.2023.2269634

APA

Zhang, T., Wahib, R., Zazara, D. E., Lücke, J., Shiri, A. M., Kempski, J., Zhao, L., Agalioti, T., Machicote, A. P., Giannou, O., Belios, I., Jia, R., Zhang, S., Tintelnot, J., Seese, H., Grass, J. K., Mercanoglu, B., Stern, L., Scognamiglio, P., ... Giannou, A. D. (2023). CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis. ONCOIMMUNOLOGY, 12(1), 2269634. https://doi.org/10.1080/2162402X.2023.2269634

Vancouver

Zhang T, Wahib R, Zazara DE, Lücke J, Shiri AM, Kempski J et al. CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis. ONCOIMMUNOLOGY. 2023;12(1):2269634. https://doi.org/10.1080/2162402X.2023.2269634

Bibtex

@article{c20816b8df364d40bac466f737acf1ab,
title = "CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis",
abstract = "Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis.",
keywords = "Humans, Animals, Mice, CD4-Positive T-Lymphocytes, Interleukins, Liver Neoplasms",
author = "Tao Zhang and Ramez Wahib and Zazara, {Dimitra E} and J{\"o}ran L{\"u}cke and Shiri, {Ahmad Mustafa} and Jan Kempski and Lilan Zhao and Theodora Agalioti and Machicote, {Andres Pablo} and Olympia Giannou and Ioannis Belios and Rongrong Jia and Siwen Zhang and Joseph Tintelnot and Hannes Seese and Grass, {Julia Kristin} and Baris Mercanoglu and Louisa Stern and Pasquale Scognamiglio and Mohammad Fard-Aghaie and Philipp Seeger and Jonas Wakker and Marius Kemper and Benjamin Brunswig and Anna Dupr{\'e}e and Lykoudis, {Panagis M} and Anastasia Pikouli and Emmanouil Giorgakis and Pablo Stringa and Natalia Lausada and Gentilini, {Maria Virginia} and Gondolesi, {Gabriel E} and Kai Bachmann and Philipp Busch and Rainer Grotel{\"u}schen and Maroulis, {Ioannis C} and Arck, {Petra C} and Ryosuke Nakano and Thomson, {Angus W} and Tarik Ghadban and Michael Tachezy and Nathaniel Melling and Eike-Gert Achilles and Puelles, {Victor G} and Felix Nickel and Thilo Hackert and Oliver Mann and Izbicki, {Jakob R} and Jun Li and Nicola Gagliani and Samuel Huber and Giannou, {Anastasios D}",
note = "{\textcopyright} 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.",
year = "2023",
doi = "10.1080/2162402X.2023.2269634",
language = "English",
volume = "12",
pages = "2269634",
journal = "ONCOIMMUNOLOGY",
issn = "2162-402X",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis

AU - Zhang, Tao

AU - Wahib, Ramez

AU - Zazara, Dimitra E

AU - Lücke, Jöran

AU - Shiri, Ahmad Mustafa

AU - Kempski, Jan

AU - Zhao, Lilan

AU - Agalioti, Theodora

AU - Machicote, Andres Pablo

AU - Giannou, Olympia

AU - Belios, Ioannis

AU - Jia, Rongrong

AU - Zhang, Siwen

AU - Tintelnot, Joseph

AU - Seese, Hannes

AU - Grass, Julia Kristin

AU - Mercanoglu, Baris

AU - Stern, Louisa

AU - Scognamiglio, Pasquale

AU - Fard-Aghaie, Mohammad

AU - Seeger, Philipp

AU - Wakker, Jonas

AU - Kemper, Marius

AU - Brunswig, Benjamin

AU - Duprée, Anna

AU - Lykoudis, Panagis M

AU - Pikouli, Anastasia

AU - Giorgakis, Emmanouil

AU - Stringa, Pablo

AU - Lausada, Natalia

AU - Gentilini, Maria Virginia

AU - Gondolesi, Gabriel E

AU - Bachmann, Kai

AU - Busch, Philipp

AU - Grotelüschen, Rainer

AU - Maroulis, Ioannis C

AU - Arck, Petra C

AU - Nakano, Ryosuke

AU - Thomson, Angus W

AU - Ghadban, Tarik

AU - Tachezy, Michael

AU - Melling, Nathaniel

AU - Achilles, Eike-Gert

AU - Puelles, Victor G

AU - Nickel, Felix

AU - Hackert, Thilo

AU - Mann, Oliver

AU - Izbicki, Jakob R

AU - Li, Jun

AU - Gagliani, Nicola

AU - Huber, Samuel

AU - Giannou, Anastasios D

N1 - © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

PY - 2023

Y1 - 2023

N2 - Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis.

AB - Metastasis is a cancer-related systemic disease and is responsible for the greatest mortality rate among cancer patients. Interestingly, the interaction between the immune system and cancer cells seems to play a key role in metastasis formation in the target organ. However, this complex network is only partially understood. We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. Based on these data, we aimed here to decipher the role of IL-22 in the last step of metastasis formation. We found that IL-22 levels were increased in established metastatic sites in both human and mouse. We also found that Th22 cells were the key source of IL-22 in established metastasis sites, and that deletion of IL-22 in CD4+ T cells was protective in liver metastasis formation. Accordingly, the administration of a murine IL-22 neutralizing antibody in the establishment of metastasis formation significantly reduced the metastatic burden in a mouse model. Mechanistically, IL-22-producing Th22 cells promoted angiogenesis in established metastasis sites. In conclusion, our findings highlight that IL-22 is equally as important in contributing to metastasis formation at late metastatic stages, and thus, identify it as a novel therapeutic target in established metastasis.

KW - Humans

KW - Animals

KW - Mice

KW - CD4-Positive T-Lymphocytes

KW - Interleukins

KW - Liver Neoplasms

U2 - 10.1080/2162402X.2023.2269634

DO - 10.1080/2162402X.2023.2269634

M3 - SCORING: Journal article

C2 - 37876835

VL - 12

SP - 2269634

JO - ONCOIMMUNOLOGY

JF - ONCOIMMUNOLOGY

SN - 2162-402X

IS - 1

ER -