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CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation

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CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation. / Schneider, Michael; Schumacher, Valéa; Lischke, Timo; Lücke, Karsten; Meyer-Schwesinger, Catherine; Velden, Joachim; Nolte, Friedrich; Mittrücker, Hans-Willi.

In: PLOS ONE, Vol. 10, No. 5, 2015, p. e0126007.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schneider, M, Schumacher, V, Lischke, T, Lücke, K, Meyer-Schwesinger, C, Velden, J, Nolte, F & Mittrücker, H-W 2015, 'CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation', PLOS ONE, vol. 10, no. 5, pp. e0126007. https://doi.org/10.1371/journal.pone.0126007

APA

Schneider, M., Schumacher, V., Lischke, T., Lücke, K., Meyer-Schwesinger, C., Velden, J., Nolte, F., & Mittrücker, H-W. (2015). CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation. PLOS ONE, 10(5), e0126007. https://doi.org/10.1371/journal.pone.0126007

Vancouver

Schneider M, Schumacher V, Lischke T, Lücke K, Meyer-Schwesinger C, Velden J et al. CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation. PLOS ONE. 2015;10(5):e0126007. https://doi.org/10.1371/journal.pone.0126007

Bibtex

@article{99eeb524a37145139bdfcf3d884cade8,
title = "CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation",
abstract = "The enzyme CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis. Here, we show that under homeostatic conditions CD38 is highly expressed on immune cells of the colon mucosa of C57BL/6 mice. Myeloid cells recruited to this tissue upon inflammation also express enhanced levels of CD38. To determine the role of CD38 in intestinal inflammation, we applied the dextran sulfate sodium (DSS) colitis model. Whereas wild-type mice developed severe colitis, CD38-/- mice had only mild disease following DSS-treatment. Histologic examination of the colon mucosa revealed pronounced inflammatory damage with dense infiltrates containing numerous granulocytes and macrophages in wild-type animals, while these findings were significantly attenuated in CD38-/- mice. Despite attenuated histological findings, the mRNA expression of inflammatory cytokines and chemokines was only marginally lower in the colons of CD38-/- mice as compared to wild-type mice. In conclusion, our results identify a function for CD38 in the control of inflammatory processes in the colon.",
author = "Michael Schneider and Val{\'e}a Schumacher and Timo Lischke and Karsten L{\"u}cke and Catherine Meyer-Schwesinger and Joachim Velden and Friedrich Nolte and Hans-Willi Mittr{\"u}cker",
year = "2015",
doi = "10.1371/journal.pone.0126007",
language = "English",
volume = "10",
pages = "e0126007",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation

AU - Schneider, Michael

AU - Schumacher, Valéa

AU - Lischke, Timo

AU - Lücke, Karsten

AU - Meyer-Schwesinger, Catherine

AU - Velden, Joachim

AU - Nolte, Friedrich

AU - Mittrücker, Hans-Willi

PY - 2015

Y1 - 2015

N2 - The enzyme CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis. Here, we show that under homeostatic conditions CD38 is highly expressed on immune cells of the colon mucosa of C57BL/6 mice. Myeloid cells recruited to this tissue upon inflammation also express enhanced levels of CD38. To determine the role of CD38 in intestinal inflammation, we applied the dextran sulfate sodium (DSS) colitis model. Whereas wild-type mice developed severe colitis, CD38-/- mice had only mild disease following DSS-treatment. Histologic examination of the colon mucosa revealed pronounced inflammatory damage with dense infiltrates containing numerous granulocytes and macrophages in wild-type animals, while these findings were significantly attenuated in CD38-/- mice. Despite attenuated histological findings, the mRNA expression of inflammatory cytokines and chemokines was only marginally lower in the colons of CD38-/- mice as compared to wild-type mice. In conclusion, our results identify a function for CD38 in the control of inflammatory processes in the colon.

AB - The enzyme CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis. Here, we show that under homeostatic conditions CD38 is highly expressed on immune cells of the colon mucosa of C57BL/6 mice. Myeloid cells recruited to this tissue upon inflammation also express enhanced levels of CD38. To determine the role of CD38 in intestinal inflammation, we applied the dextran sulfate sodium (DSS) colitis model. Whereas wild-type mice developed severe colitis, CD38-/- mice had only mild disease following DSS-treatment. Histologic examination of the colon mucosa revealed pronounced inflammatory damage with dense infiltrates containing numerous granulocytes and macrophages in wild-type animals, while these findings were significantly attenuated in CD38-/- mice. Despite attenuated histological findings, the mRNA expression of inflammatory cytokines and chemokines was only marginally lower in the colons of CD38-/- mice as compared to wild-type mice. In conclusion, our results identify a function for CD38 in the control of inflammatory processes in the colon.

U2 - 10.1371/journal.pone.0126007

DO - 10.1371/journal.pone.0126007

M3 - SCORING: Journal article

C2 - 25938500

VL - 10

SP - e0126007

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 5

ER -