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CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.

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CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin. / Wessel, Cordula; Westhoff, Christina C; Nowak, Katharina; Moll, Ingrid; Barth, Peter J.

In: VIRCHOWS ARCH, Vol. 453, No. 5, 5, 2008, p. 485-489.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wessel, C, Westhoff, CC, Nowak, K, Moll, I & Barth, PJ 2008, 'CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.', VIRCHOWS ARCH, vol. 453, no. 5, 5, pp. 485-489. <http://www.ncbi.nlm.nih.gov/pubmed/18813945?dopt=Citation>

APA

Wessel, C., Westhoff, C. C., Nowak, K., Moll, I., & Barth, P. J. (2008). CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin. VIRCHOWS ARCH, 453(5), 485-489. [5]. http://www.ncbi.nlm.nih.gov/pubmed/18813945?dopt=Citation

Vancouver

Wessel C, Westhoff CC, Nowak K, Moll I, Barth PJ. CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin. VIRCHOWS ARCH. 2008;453(5):485-489. 5.

Bibtex

@article{3f518c35771f48d48ff76746f9e6c1dc,
title = "CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.",
abstract = "CD34(+) fibrocytes are constitutive elements of the human connective tissue. The stroma associated with invasive carcinomas is characterized by a stereotypic loss of CD34(+) fibrocytes and a phenotype change towards CD34(-) alpha-Smooth muscle actin (SMA)(+) myofibroblasts. Secreted protein acidic and rich in cysteine (SPARC) is an important mediator of tumor-associated stromal remodeling. Melanocytic lesions of the skin have not been investigated as to this aspect up to now. Thus, we investigated a total of 20 malignant melanomas and 29 melanocytic nevi. The normal dermis and benign melanocytic nevi showed numerous CD34(+) fibrocytes, whereas malignant melanomas were devoid of this cell type. alpha-SMA-positive myofibroblasts were absent from the normal dermis, melanocytic nevi, and malignant melanomas. SPARC was positive in malignant melanoma cells and negative in their associated stroma, while all melanocytic nevi were completely negative. The stromal phenotype of malignant melanomas (CD34(-) alpha-SMA(-)) differs from that of invasive carcinomas (CD34(-) alpha-SMA(+)) suggesting different pathogenic mechanisms involved in tumor-associated stromal remodeling. SPARC expression appears to be closely related to malignancy in melanocytic lesions.",
author = "Cordula Wessel and Westhoff, {Christina C} and Katharina Nowak and Ingrid Moll and Barth, {Peter J}",
year = "2008",
language = "Deutsch",
volume = "453",
pages = "485--489",
journal = "VIRCHOWS ARCH",
issn = "0945-6317",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.

AU - Wessel, Cordula

AU - Westhoff, Christina C

AU - Nowak, Katharina

AU - Moll, Ingrid

AU - Barth, Peter J

PY - 2008

Y1 - 2008

N2 - CD34(+) fibrocytes are constitutive elements of the human connective tissue. The stroma associated with invasive carcinomas is characterized by a stereotypic loss of CD34(+) fibrocytes and a phenotype change towards CD34(-) alpha-Smooth muscle actin (SMA)(+) myofibroblasts. Secreted protein acidic and rich in cysteine (SPARC) is an important mediator of tumor-associated stromal remodeling. Melanocytic lesions of the skin have not been investigated as to this aspect up to now. Thus, we investigated a total of 20 malignant melanomas and 29 melanocytic nevi. The normal dermis and benign melanocytic nevi showed numerous CD34(+) fibrocytes, whereas malignant melanomas were devoid of this cell type. alpha-SMA-positive myofibroblasts were absent from the normal dermis, melanocytic nevi, and malignant melanomas. SPARC was positive in malignant melanoma cells and negative in their associated stroma, while all melanocytic nevi were completely negative. The stromal phenotype of malignant melanomas (CD34(-) alpha-SMA(-)) differs from that of invasive carcinomas (CD34(-) alpha-SMA(+)) suggesting different pathogenic mechanisms involved in tumor-associated stromal remodeling. SPARC expression appears to be closely related to malignancy in melanocytic lesions.

AB - CD34(+) fibrocytes are constitutive elements of the human connective tissue. The stroma associated with invasive carcinomas is characterized by a stereotypic loss of CD34(+) fibrocytes and a phenotype change towards CD34(-) alpha-Smooth muscle actin (SMA)(+) myofibroblasts. Secreted protein acidic and rich in cysteine (SPARC) is an important mediator of tumor-associated stromal remodeling. Melanocytic lesions of the skin have not been investigated as to this aspect up to now. Thus, we investigated a total of 20 malignant melanomas and 29 melanocytic nevi. The normal dermis and benign melanocytic nevi showed numerous CD34(+) fibrocytes, whereas malignant melanomas were devoid of this cell type. alpha-SMA-positive myofibroblasts were absent from the normal dermis, melanocytic nevi, and malignant melanomas. SPARC was positive in malignant melanoma cells and negative in their associated stroma, while all melanocytic nevi were completely negative. The stromal phenotype of malignant melanomas (CD34(-) alpha-SMA(-)) differs from that of invasive carcinomas (CD34(-) alpha-SMA(+)) suggesting different pathogenic mechanisms involved in tumor-associated stromal remodeling. SPARC expression appears to be closely related to malignancy in melanocytic lesions.

M3 - SCORING: Zeitschriftenaufsatz

VL - 453

SP - 485

EP - 489

JO - VIRCHOWS ARCH

JF - VIRCHOWS ARCH

SN - 0945-6317

IS - 5

M1 - 5

ER -