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CD24 polymorphisms in breast cancer: impact on prognosis and risk

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CD24 polymorphisms in breast cancer: impact on prognosis and risk. / Buck, Katharina; Hug, Sarah; Seibold, Petra; Ferschke, Irmgard; Altevogt, Peter; Sohn, Christof; Schneeweiss, Andreas; Burwinkel, Barbara; Jäger, Dirk; Flesch-Janys, Dieter; Chang-Claude, Jenny; Marmé, Frederik.

In: BREAST CANCER RES TR, Vol. 137, No. 3, 01.02.2013, p. 927-37.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Buck, K, Hug, S, Seibold, P, Ferschke, I, Altevogt, P, Sohn, C, Schneeweiss, A, Burwinkel, B, Jäger, D, Flesch-Janys, D, Chang-Claude, J & Marmé, F 2013, 'CD24 polymorphisms in breast cancer: impact on prognosis and risk', BREAST CANCER RES TR, vol. 137, no. 3, pp. 927-37. https://doi.org/10.1007/s10549-012-2325-9

APA

Buck, K., Hug, S., Seibold, P., Ferschke, I., Altevogt, P., Sohn, C., Schneeweiss, A., Burwinkel, B., Jäger, D., Flesch-Janys, D., Chang-Claude, J., & Marmé, F. (2013). CD24 polymorphisms in breast cancer: impact on prognosis and risk. BREAST CANCER RES TR, 137(3), 927-37. https://doi.org/10.1007/s10549-012-2325-9

Vancouver

Buck K, Hug S, Seibold P, Ferschke I, Altevogt P, Sohn C et al. CD24 polymorphisms in breast cancer: impact on prognosis and risk. BREAST CANCER RES TR. 2013 Feb 1;137(3):927-37. https://doi.org/10.1007/s10549-012-2325-9

Bibtex

@article{b5e0d3dd26a443e4a0a3673db098b1c9,
title = "CD24 polymorphisms in breast cancer: impact on prognosis and risk",
abstract = "Overexpression of CD24 has a negative impact on breast cancer prognosis. We have recently reported that the CD24 codon 57 Val/Val genotype (rs52812045) is associated with pathologic complete response after neoadjuvant chemotherapy for primary breast cancer and correlates with intratumoral lymphocyte infiltrates. This study was performed to investigate the influence of CD24 polymorphisms on breast cancer prognosis and risk. A total of 2,514 patients and 4,858 controls recruited as part of the MARIE study, a population-based case-control study, were genotyped for two CD24 polymorphisms (rs52812045, rs3838646) using TaqMan custom genotyping assays. Associations with overall and breast cancer-specific survival were assessed using uni- and multivariable Cox regression models stratified by age at diagnosis and adjusted for prognostic factors. Conditional logistic regression analysis adjusted for major risk factors was used to estimate multivariable odds ratios for risk of putative allele carriers compared to wildtype carriers. CD24 Ala/Val was significantly associated with breast cancer prognosis [Val/Val hazard ratio (HR)(adjusted) = 1.52; 95 % confidence interval (CI): 1.00-2.30, p = 0.05 and HR(adjusted) = 1.83; 95 % CI: 1.10-3.05, p = 0.018 for all-cause and breast cancer-specific mortality, respectively). The association was significant only in patients with a BMI <25 and in those who received adjuvant chemotherapy. None of the CD24 alleles was associated with breast cancer risk. These results provide further evidence of the CD24 Val/Val genotype influencing outcome in primary breast cancer. Together with previous data of CD24 overexpression as a poor prognostic marker, the findings underline the biological importance of CD24 for breast cancer.",
keywords = "3' Untranslated Regions, Aged, Antigens, CD24, Breast Neoplasms, Case-Control Studies, Female, Genotype, Humans, Middle Aged, Neoplasm Staging, Polymorphism, Genetic, Prognosis, Risk",
author = "Katharina Buck and Sarah Hug and Petra Seibold and Irmgard Ferschke and Peter Altevogt and Christof Sohn and Andreas Schneeweiss and Barbara Burwinkel and Dirk J{\"a}ger and Dieter Flesch-Janys and Jenny Chang-Claude and Frederik Marm{\'e}",
year = "2013",
month = feb,
day = "1",
doi = "10.1007/s10549-012-2325-9",
language = "English",
volume = "137",
pages = "927--37",
journal = "BREAST CANCER RES TR",
issn = "0167-6806",
publisher = "Springer New York",
number = "3",

}

RIS

TY - JOUR

T1 - CD24 polymorphisms in breast cancer: impact on prognosis and risk

AU - Buck, Katharina

AU - Hug, Sarah

AU - Seibold, Petra

AU - Ferschke, Irmgard

AU - Altevogt, Peter

AU - Sohn, Christof

AU - Schneeweiss, Andreas

AU - Burwinkel, Barbara

AU - Jäger, Dirk

AU - Flesch-Janys, Dieter

AU - Chang-Claude, Jenny

AU - Marmé, Frederik

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Overexpression of CD24 has a negative impact on breast cancer prognosis. We have recently reported that the CD24 codon 57 Val/Val genotype (rs52812045) is associated with pathologic complete response after neoadjuvant chemotherapy for primary breast cancer and correlates with intratumoral lymphocyte infiltrates. This study was performed to investigate the influence of CD24 polymorphisms on breast cancer prognosis and risk. A total of 2,514 patients and 4,858 controls recruited as part of the MARIE study, a population-based case-control study, were genotyped for two CD24 polymorphisms (rs52812045, rs3838646) using TaqMan custom genotyping assays. Associations with overall and breast cancer-specific survival were assessed using uni- and multivariable Cox regression models stratified by age at diagnosis and adjusted for prognostic factors. Conditional logistic regression analysis adjusted for major risk factors was used to estimate multivariable odds ratios for risk of putative allele carriers compared to wildtype carriers. CD24 Ala/Val was significantly associated with breast cancer prognosis [Val/Val hazard ratio (HR)(adjusted) = 1.52; 95 % confidence interval (CI): 1.00-2.30, p = 0.05 and HR(adjusted) = 1.83; 95 % CI: 1.10-3.05, p = 0.018 for all-cause and breast cancer-specific mortality, respectively). The association was significant only in patients with a BMI <25 and in those who received adjuvant chemotherapy. None of the CD24 alleles was associated with breast cancer risk. These results provide further evidence of the CD24 Val/Val genotype influencing outcome in primary breast cancer. Together with previous data of CD24 overexpression as a poor prognostic marker, the findings underline the biological importance of CD24 for breast cancer.

AB - Overexpression of CD24 has a negative impact on breast cancer prognosis. We have recently reported that the CD24 codon 57 Val/Val genotype (rs52812045) is associated with pathologic complete response after neoadjuvant chemotherapy for primary breast cancer and correlates with intratumoral lymphocyte infiltrates. This study was performed to investigate the influence of CD24 polymorphisms on breast cancer prognosis and risk. A total of 2,514 patients and 4,858 controls recruited as part of the MARIE study, a population-based case-control study, were genotyped for two CD24 polymorphisms (rs52812045, rs3838646) using TaqMan custom genotyping assays. Associations with overall and breast cancer-specific survival were assessed using uni- and multivariable Cox regression models stratified by age at diagnosis and adjusted for prognostic factors. Conditional logistic regression analysis adjusted for major risk factors was used to estimate multivariable odds ratios for risk of putative allele carriers compared to wildtype carriers. CD24 Ala/Val was significantly associated with breast cancer prognosis [Val/Val hazard ratio (HR)(adjusted) = 1.52; 95 % confidence interval (CI): 1.00-2.30, p = 0.05 and HR(adjusted) = 1.83; 95 % CI: 1.10-3.05, p = 0.018 for all-cause and breast cancer-specific mortality, respectively). The association was significant only in patients with a BMI <25 and in those who received adjuvant chemotherapy. None of the CD24 alleles was associated with breast cancer risk. These results provide further evidence of the CD24 Val/Val genotype influencing outcome in primary breast cancer. Together with previous data of CD24 overexpression as a poor prognostic marker, the findings underline the biological importance of CD24 for breast cancer.

KW - 3' Untranslated Regions

KW - Aged

KW - Antigens, CD24

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Female

KW - Genotype

KW - Humans

KW - Middle Aged

KW - Neoplasm Staging

KW - Polymorphism, Genetic

KW - Prognosis

KW - Risk

U2 - 10.1007/s10549-012-2325-9

DO - 10.1007/s10549-012-2325-9

M3 - SCORING: Journal article

C2 - 23314606

VL - 137

SP - 927

EP - 937

JO - BREAST CANCER RES TR

JF - BREAST CANCER RES TR

SN - 0167-6806

IS - 3

ER -