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CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort

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CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort. / Grass, Julia-Kristin; Grupp, Katharina; Kluth, Martina; Hube-Magg, Claudia; Simon, Ronald; Kemper, Marius; Izbicki, Jakob R; Sauter, Guido; Melling, Nathaniel.

In: CANCERS, Vol. 16, No. 8, 11.04.2024.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Grass, J-K, Grupp, K, Kluth, M, Hube-Magg, C, Simon, R, Kemper, M, Izbicki, JR, Sauter, G & Melling, N 2024, 'CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort', CANCERS, vol. 16, no. 8. https://doi.org/10.3390/cancers16081473

APA

Grass, J-K., Grupp, K., Kluth, M., Hube-Magg, C., Simon, R., Kemper, M., Izbicki, J. R., Sauter, G., & Melling, N. (2024). CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort. CANCERS, 16(8). https://doi.org/10.3390/cancers16081473

Vancouver

Grass J-K, Grupp K, Kluth M, Hube-Magg C, Simon R, Kemper M et al. CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort. CANCERS. 2024 Apr 11;16(8). https://doi.org/10.3390/cancers16081473

Bibtex

@article{adfbb81076814a43b82fa62ec4bae2e2,
title = "CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort",
abstract = "The role of CD10 expression in colorectal cancer has been controversially discussed in the literature. Some data suggest a predictive capacity for lymph node and liver metastases, thus influencing overall survival (OS) and disease-free survival (DFS). This study aims to analyse the relationship between CD10 expression and overall survival (OS) in a European cohort. To determine the association of CD10 expression with tumour phenotype, molecular features, and prognosis, a tissue microarray of 1469 colorectal carcinomas was analysed using immunohistochemistry and was compared with matched clinicopathologic data. CD10 expression correlated with earlier tumour stages (p = 0.017) and left-sided colon cancer (p < 0.001). However, no correlation was found between CD10 expression and lymph node involvement (p = 0.711), tumour grading (p = 0.397), or overall survival (p = 0.562). Even in the subgroup analysis of tumour or nodal stage, CD10 did not affect overall survival, although it was significantly associated with p53 and nuclear β-catenin expression (p = 0.013 and p < 0.001, respectively). CD10 expression correlates with earlier tumour stages, colon cancer location, and indicators of aggressive CRC subtypes. However, we can exclude CD10 as a relevant independent prognosticator for CRC.",
author = "Julia-Kristin Grass and Katharina Grupp and Martina Kluth and Claudia Hube-Magg and Ronald Simon and Marius Kemper and Izbicki, {Jakob R} and Guido Sauter and Nathaniel Melling",
year = "2024",
month = apr,
day = "11",
doi = "10.3390/cancers16081473",
language = "English",
volume = "16",
journal = "CANCERS",
issn = "2072-6694",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",

}

RIS

TY - JOUR

T1 - CD10 Expression Correlates with Earlier Tumour Stages and Left-Sided Tumour Location in Colorectal Cancer but Has No Prognostic Impact in a European Cohort

AU - Grass, Julia-Kristin

AU - Grupp, Katharina

AU - Kluth, Martina

AU - Hube-Magg, Claudia

AU - Simon, Ronald

AU - Kemper, Marius

AU - Izbicki, Jakob R

AU - Sauter, Guido

AU - Melling, Nathaniel

PY - 2024/4/11

Y1 - 2024/4/11

N2 - The role of CD10 expression in colorectal cancer has been controversially discussed in the literature. Some data suggest a predictive capacity for lymph node and liver metastases, thus influencing overall survival (OS) and disease-free survival (DFS). This study aims to analyse the relationship between CD10 expression and overall survival (OS) in a European cohort. To determine the association of CD10 expression with tumour phenotype, molecular features, and prognosis, a tissue microarray of 1469 colorectal carcinomas was analysed using immunohistochemistry and was compared with matched clinicopathologic data. CD10 expression correlated with earlier tumour stages (p = 0.017) and left-sided colon cancer (p < 0.001). However, no correlation was found between CD10 expression and lymph node involvement (p = 0.711), tumour grading (p = 0.397), or overall survival (p = 0.562). Even in the subgroup analysis of tumour or nodal stage, CD10 did not affect overall survival, although it was significantly associated with p53 and nuclear β-catenin expression (p = 0.013 and p < 0.001, respectively). CD10 expression correlates with earlier tumour stages, colon cancer location, and indicators of aggressive CRC subtypes. However, we can exclude CD10 as a relevant independent prognosticator for CRC.

AB - The role of CD10 expression in colorectal cancer has been controversially discussed in the literature. Some data suggest a predictive capacity for lymph node and liver metastases, thus influencing overall survival (OS) and disease-free survival (DFS). This study aims to analyse the relationship between CD10 expression and overall survival (OS) in a European cohort. To determine the association of CD10 expression with tumour phenotype, molecular features, and prognosis, a tissue microarray of 1469 colorectal carcinomas was analysed using immunohistochemistry and was compared with matched clinicopathologic data. CD10 expression correlated with earlier tumour stages (p = 0.017) and left-sided colon cancer (p < 0.001). However, no correlation was found between CD10 expression and lymph node involvement (p = 0.711), tumour grading (p = 0.397), or overall survival (p = 0.562). Even in the subgroup analysis of tumour or nodal stage, CD10 did not affect overall survival, although it was significantly associated with p53 and nuclear β-catenin expression (p = 0.013 and p < 0.001, respectively). CD10 expression correlates with earlier tumour stages, colon cancer location, and indicators of aggressive CRC subtypes. However, we can exclude CD10 as a relevant independent prognosticator for CRC.

U2 - 10.3390/cancers16081473

DO - 10.3390/cancers16081473

M3 - SCORING: Journal article

C2 - 38672555

VL - 16

JO - CANCERS

JF - CANCERS

SN - 2072-6694

IS - 8

ER -