Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry

Harilaos Bogossian; Johannes Brachmann; Thorsten Lewalter; Ellen Hoffmann; Karl Heinz Kuck; Dietrich Andresen; Stephan Willems; Stefan G Spitzer; Thomas Deneke; Dierk Thomas; Matthias Hochadel; Jochen Senges; Lars Eckardt; Bernd Lemke

doi:10.1016/j.ijcard.2016.03.069

Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry

Standard

Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry. / Bogossian, Harilaos; Brachmann, Johannes; Lewalter, Thorsten; Hoffmann, Ellen; Kuck, Karl Heinz; Andresen, Dietrich; Willems, Stephan; Spitzer, Stefan G; Deneke, Thomas; Thomas, Dierk; Hochadel, Matthias; Senges, Jochen; Eckardt, Lars; Lemke, Bernd.

In: INT J CARDIOL, Vol. 214, 01.07.2016, p. 25-30.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bogossian, H, Brachmann, J, Lewalter, T, Hoffmann, E, Kuck, KH, Andresen, D, Willems, S, Spitzer, SG, Deneke, T, Thomas, D, Hochadel, M, Senges, J, Eckardt, L & Lemke, B 2016, 'Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry', INT J CARDIOL, vol. 214, pp. 25-30. https://doi.org/10.1016/j.ijcard.2016.03.069

APA

Bogossian, H., Brachmann, J., Lewalter, T., Hoffmann, E., Kuck, K. H., Andresen, D., Willems, S., Spitzer, S. G., Deneke, T., Thomas, D., Hochadel, M., Senges, J., Eckardt, L., & Lemke, B. (2016). Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry. INT J CARDIOL, 214, 25-30. https://doi.org/10.1016/j.ijcard.2016.03.069

Vancouver

Bogossian H, Brachmann J, Lewalter T, Hoffmann E, Kuck KH, Andresen D et al. Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry. INT J CARDIOL. 2016 Jul 1;214:25-30. https://doi.org/10.1016/j.ijcard.2016.03.069

Bibtex

@article{04ef926371234286868441eed6a01eb5,

title = "Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry",

abstract = "BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for cardiovascular disease and arrhythmias. Procedural data and complication rates in patients with DM undergoing catheter ablation for atrial arrhythmias are unknown.METHODS: The German Ablation Registry has been designed as a multi-center prospective registry. Between January 2007 and January 2010 data from ablation of right atrial flutter (AFlut) and atrial fibrillation (AF) were collected from 51 German centres. Patients with DM and without DM were compared.RESULTS: We included 8175 patients who underwent catheter ablation of AFlut or AF. Patients with DM (n=944) were older and presented significantly more severe comorbidities. Major periprocedural complications did not significantly differ between patients with and without DM for both ablation of AFlut and AF. Kaplan-Meier survival analysis for 366days of follow-up, showed a significant increase of MACCE for DM patients as compared to controls after AFlut [6.1% vs. 3.4%(p=0.002)], but not after AF ablation [1.2% vs. 0.9%(p=0.59)]. Ablation of AFlut led to a comparable reduction of palpitations and NYHA class in both patient groups. AF ablation reduced palpitations and NYHA class in patients without DM, while patients with DM reported no improvement of NYHA class despite a reduction of palpitations.CONCLUSION: As compared to non-DM, patients with DM show no increased periprocedural risk and no increased arrhythmia recurrence after ablation of AFlut or AF. As expected patients with DM exhibit more comorbidities and an increased ongoing mortality after atrial flutter ablation presumably caused by the higher age of this group as compared to controls.",

keywords = "Aged, Atrial Fibrillation/epidemiology, Atrial Flutter/epidemiology, Catheter Ablation/methods, Diabetes Complications/epidemiology, Diabetes Mellitus/epidemiology, Female, Germany/epidemiology, Humans, Male, Middle Aged, Prospective Studies, Registries, Treatment Outcome",

author = "Harilaos Bogossian and Johannes Brachmann and Thorsten Lewalter and Ellen Hoffmann and Kuck, {Karl Heinz} and Dietrich Andresen and Stephan Willems and Spitzer, {Stefan G} and Thomas Deneke and Dierk Thomas and Matthias Hochadel and Jochen Senges and Lars Eckardt and Bernd Lemke",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.ijcard.2016.03.069",

language = "English",

volume = "214",

pages = "25--30",

journal = "INT J CARDIOL",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Catheter ablation of atrial fibrillation and atrial flutter in patients with diabetes mellitus: Who benefits and who does not? Data from the German ablation registry

AU - Bogossian, Harilaos

AU - Brachmann, Johannes

AU - Lewalter, Thorsten

AU - Hoffmann, Ellen

AU - Kuck, Karl Heinz

AU - Andresen, Dietrich

AU - Willems, Stephan

AU - Spitzer, Stefan G

AU - Deneke, Thomas

AU - Thomas, Dierk

AU - Hochadel, Matthias

AU - Senges, Jochen

AU - Eckardt, Lars

AU - Lemke, Bernd

PY - 2016/7/1

Y1 - 2016/7/1

N2 - BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for cardiovascular disease and arrhythmias. Procedural data and complication rates in patients with DM undergoing catheter ablation for atrial arrhythmias are unknown.METHODS: The German Ablation Registry has been designed as a multi-center prospective registry. Between January 2007 and January 2010 data from ablation of right atrial flutter (AFlut) and atrial fibrillation (AF) were collected from 51 German centres. Patients with DM and without DM were compared.RESULTS: We included 8175 patients who underwent catheter ablation of AFlut or AF. Patients with DM (n=944) were older and presented significantly more severe comorbidities. Major periprocedural complications did not significantly differ between patients with and without DM for both ablation of AFlut and AF. Kaplan-Meier survival analysis for 366days of follow-up, showed a significant increase of MACCE for DM patients as compared to controls after AFlut [6.1% vs. 3.4%(p=0.002)], but not after AF ablation [1.2% vs. 0.9%(p=0.59)]. Ablation of AFlut led to a comparable reduction of palpitations and NYHA class in both patient groups. AF ablation reduced palpitations and NYHA class in patients without DM, while patients with DM reported no improvement of NYHA class despite a reduction of palpitations.CONCLUSION: As compared to non-DM, patients with DM show no increased periprocedural risk and no increased arrhythmia recurrence after ablation of AFlut or AF. As expected patients with DM exhibit more comorbidities and an increased ongoing mortality after atrial flutter ablation presumably caused by the higher age of this group as compared to controls.

AB - BACKGROUND: Diabetes mellitus (DM) is an independent risk factor for cardiovascular disease and arrhythmias. Procedural data and complication rates in patients with DM undergoing catheter ablation for atrial arrhythmias are unknown.METHODS: The German Ablation Registry has been designed as a multi-center prospective registry. Between January 2007 and January 2010 data from ablation of right atrial flutter (AFlut) and atrial fibrillation (AF) were collected from 51 German centres. Patients with DM and without DM were compared.RESULTS: We included 8175 patients who underwent catheter ablation of AFlut or AF. Patients with DM (n=944) were older and presented significantly more severe comorbidities. Major periprocedural complications did not significantly differ between patients with and without DM for both ablation of AFlut and AF. Kaplan-Meier survival analysis for 366days of follow-up, showed a significant increase of MACCE for DM patients as compared to controls after AFlut [6.1% vs. 3.4%(p=0.002)], but not after AF ablation [1.2% vs. 0.9%(p=0.59)]. Ablation of AFlut led to a comparable reduction of palpitations and NYHA class in both patient groups. AF ablation reduced palpitations and NYHA class in patients without DM, while patients with DM reported no improvement of NYHA class despite a reduction of palpitations.CONCLUSION: As compared to non-DM, patients with DM show no increased periprocedural risk and no increased arrhythmia recurrence after ablation of AFlut or AF. As expected patients with DM exhibit more comorbidities and an increased ongoing mortality after atrial flutter ablation presumably caused by the higher age of this group as compared to controls.

KW - Aged

KW - Atrial Fibrillation/epidemiology

KW - Atrial Flutter/epidemiology

KW - Catheter Ablation/methods

KW - Diabetes Complications/epidemiology

KW - Diabetes Mellitus/epidemiology

KW - Female

KW - Germany/epidemiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Registries

KW - Treatment Outcome

U2 - 10.1016/j.ijcard.2016.03.069

DO - 10.1016/j.ijcard.2016.03.069

M3 - SCORING: Journal article

C2 - 27057967

VL - 214

SP - 25

EP - 30

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

ER -