Research ExplorerPublicationsCardiovascular magnetic resonance demonstrates structural ca...

Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt

Standard

Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt. / Radunski, Ulf K; Kluwe, Johannes; Klein, Malte; Galante, Antonio; Lund, Gunnar K; Sinning, Christoph; Bohnen, Sebastian; Tahir, Enver; Starekova, Jitka; Bannas, Peter; Stehning, Christian; Adam, Gerhard; Lohse, Ansgar W; Blankenberg, Stefan; Muellerleile, Kai; Benten, Daniel.

In: SCI REP-UK, Vol. 11, No. 1, 12719, 16.06.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Radunski, UK, Kluwe, J, Klein, M, Galante, A, Lund, GK, Sinning, C, Bohnen, S, Tahir, E, Starekova, J, Bannas, P, Stehning, C, Adam, G, Lohse, AW, Blankenberg, S, Muellerleile, K & Benten, D 2021, 'Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt', SCI REP-UK, vol. 11, no. 1, 12719. https://doi.org/10.1038/s41598-021-92064-8

APA

Radunski, U. K., Kluwe, J., Klein, M., Galante, A., Lund, G. K., Sinning, C., Bohnen, S., Tahir, E., Starekova, J., Bannas, P., Stehning, C., Adam, G., Lohse, A. W., Blankenberg, S., Muellerleile, K., & Benten, D. (2021). Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt. SCI REP-UK, 11(1), [12719]. https://doi.org/10.1038/s41598-021-92064-8

Vancouver

Radunski UK, Kluwe J, Klein M, Galante A, Lund GK, Sinning C et al. Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt. SCI REP-UK. 2021 Jun 16;11(1). 12719. https://doi.org/10.1038/s41598-021-92064-8

Bibtex

@article{fd6a3af66e54440d93233ce1b9fe3ce4,
title = "Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt",
abstract = "Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifying cardiac volumes and ventricular function. The aim of this study was to investigate effects of TIPS on the heart using CMR, laboratory, and imaging cardiac biomarkers. 34 consecutive patients with liver cirrhosis were evaluated for TIPS. Comprehensive CMR with native T1 mapping, transthoracic echocardiography, and laboratory biomarkers were assessed before and after TIPS insertion. Follow-up (FU) CMR was obtained in 16 patients (47%) 207 (170-245) days after TIPS. From baseline (BL) to FU, a significant increase of all indexed cardiac chamber volumes was observed (all P < 0.05). Left ventricular (LV) end-diastolic mass index increased significantly from 45 (38-51) to 65 (51-73) g/m2 (P =  < 0.01). Biventricular systolic function, NT-proBNP, high-sensitive troponin T, and native T1 time did not differ significantly from BL to FU. No patient experienced cardiac decompensation following TIPS. In conclusion, in patients without clinically significant prior heart disease, increased cardiac preload after TIPS resulted in increased volumes of all cardiac chambers and eccentric LV hypertrophy, without leading to cardiac impairment during follow-up in this selected patient population.",
keywords = "Aged, Cardiac Output, Cardiac Volume, Cardiomyopathies/diagnosis, Female, Heart/diagnostic imaging, Heart Failure/diagnosis, Humans, Liver Cirrhosis/surgery, Magnetic Resonance Imaging, Male, Middle Aged, Portasystemic Shunt, Transjugular Intrahepatic/adverse effects, Treatment Outcome",
author = "Radunski, {Ulf K} and Johannes Kluwe and Malte Klein and Antonio Galante and Lund, {Gunnar K} and Christoph Sinning and Sebastian Bohnen and Enver Tahir and Jitka Starekova and Peter Bannas and Christian Stehning and Gerhard Adam and Lohse, {Ansgar W} and Stefan Blankenberg and Kai Muellerleile and Daniel Benten",
year = "2021",
month = jun,
day = "16",
doi = "10.1038/s41598-021-92064-8",
language = "English",
volume = "11",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt

AU - Radunski, Ulf K

AU - Kluwe, Johannes

AU - Klein, Malte

AU - Galante, Antonio

AU - Lund, Gunnar K

AU - Sinning, Christoph

AU - Bohnen, Sebastian

AU - Tahir, Enver

AU - Starekova, Jitka

AU - Bannas, Peter

AU - Stehning, Christian

AU - Adam, Gerhard

AU - Lohse, Ansgar W

AU - Blankenberg, Stefan

AU - Muellerleile, Kai

AU - Benten, Daniel

PY - 2021/6/16

Y1 - 2021/6/16

N2 - Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifying cardiac volumes and ventricular function. The aim of this study was to investigate effects of TIPS on the heart using CMR, laboratory, and imaging cardiac biomarkers. 34 consecutive patients with liver cirrhosis were evaluated for TIPS. Comprehensive CMR with native T1 mapping, transthoracic echocardiography, and laboratory biomarkers were assessed before and after TIPS insertion. Follow-up (FU) CMR was obtained in 16 patients (47%) 207 (170-245) days after TIPS. From baseline (BL) to FU, a significant increase of all indexed cardiac chamber volumes was observed (all P < 0.05). Left ventricular (LV) end-diastolic mass index increased significantly from 45 (38-51) to 65 (51-73) g/m2 (P =  < 0.01). Biventricular systolic function, NT-proBNP, high-sensitive troponin T, and native T1 time did not differ significantly from BL to FU. No patient experienced cardiac decompensation following TIPS. In conclusion, in patients without clinically significant prior heart disease, increased cardiac preload after TIPS resulted in increased volumes of all cardiac chambers and eccentric LV hypertrophy, without leading to cardiac impairment during follow-up in this selected patient population.

AB - Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension in patients with liver cirrhosis. The exact cardiac consequences of subsequent increase of central blood volume are unknown. Cardiovascular magnetic resonance (CMR) imaging is the method of choice for quantifying cardiac volumes and ventricular function. The aim of this study was to investigate effects of TIPS on the heart using CMR, laboratory, and imaging cardiac biomarkers. 34 consecutive patients with liver cirrhosis were evaluated for TIPS. Comprehensive CMR with native T1 mapping, transthoracic echocardiography, and laboratory biomarkers were assessed before and after TIPS insertion. Follow-up (FU) CMR was obtained in 16 patients (47%) 207 (170-245) days after TIPS. From baseline (BL) to FU, a significant increase of all indexed cardiac chamber volumes was observed (all P < 0.05). Left ventricular (LV) end-diastolic mass index increased significantly from 45 (38-51) to 65 (51-73) g/m2 (P =  < 0.01). Biventricular systolic function, NT-proBNP, high-sensitive troponin T, and native T1 time did not differ significantly from BL to FU. No patient experienced cardiac decompensation following TIPS. In conclusion, in patients without clinically significant prior heart disease, increased cardiac preload after TIPS resulted in increased volumes of all cardiac chambers and eccentric LV hypertrophy, without leading to cardiac impairment during follow-up in this selected patient population.

KW - Aged

KW - Cardiac Output

KW - Cardiac Volume

KW - Cardiomyopathies/diagnosis

KW - Female

KW - Heart/diagnostic imaging

KW - Heart Failure/diagnosis

KW - Humans

KW - Liver Cirrhosis/surgery

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Portasystemic Shunt, Transjugular Intrahepatic/adverse effects

KW - Treatment Outcome

U2 - 10.1038/s41598-021-92064-8

DO - 10.1038/s41598-021-92064-8

M3 - SCORING: Journal article

C2 - 34135410

VL - 11

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

M1 - 12719

ER -