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Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat

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Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat. / Spechler, Philip A; Orr, Catherine A; Chaarani, Bader; Kan, Kees-Jan; Mackey, Scott; Morton, Aaron; Snowe, Mitchell P; Hudson, Kelsey E; Althoff, Robert R; Higgins, Stephen T; Cattrell, Anna; Flor, Herta; Nees, Frauke; Banaschewski, Tobias; Bokde, Arun L W; Whelan, Robert; Büchel, Christian; Bromberg, Uli; Conrod, Patricia; Frouin, Vincent; Papadopoulos, Dimitri; Gallinat, Jurgen; Heinz, Andreas; Walter, Henrik; Ittermann, Bernd; Gowland, Penny; Paus, Tomáš; Poustka, Luise; Martinot, Jean-Luc; Artiges, Eric; Smolka, Michael N; Schumann, Gunter; Garavan, Hugh; IMAGEN Consortium.

In: DEV COGN NEUROS-NETH, Vol. 16, 12.2015, p. 63-70.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Spechler, PA, Orr, CA, Chaarani, B, Kan, K-J, Mackey, S, Morton, A, Snowe, MP, Hudson, KE, Althoff, RR, Higgins, ST, Cattrell, A, Flor, H, Nees, F, Banaschewski, T, Bokde, ALW, Whelan, R, Büchel, C, Bromberg, U, Conrod, P, Frouin, V, Papadopoulos, D, Gallinat, J, Heinz, A, Walter, H, Ittermann, B, Gowland, P, Paus, T, Poustka, L, Martinot, J-L, Artiges, E, Smolka, MN, Schumann, G, Garavan, H & IMAGEN Consortium 2015, 'Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat', DEV COGN NEUROS-NETH, vol. 16, pp. 63-70. https://doi.org/10.1016/j.dcn.2015.08.007

APA

Spechler, P. A., Orr, C. A., Chaarani, B., Kan, K-J., Mackey, S., Morton, A., Snowe, M. P., Hudson, K. E., Althoff, R. R., Higgins, S. T., Cattrell, A., Flor, H., Nees, F., Banaschewski, T., Bokde, A. L. W., Whelan, R., Büchel, C., Bromberg, U., Conrod, P., ... IMAGEN Consortium (2015). Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat. DEV COGN NEUROS-NETH, 16, 63-70. https://doi.org/10.1016/j.dcn.2015.08.007

Vancouver

Spechler PA, Orr CA, Chaarani B, Kan K-J, Mackey S, Morton A et al. Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat. DEV COGN NEUROS-NETH. 2015 Dec;16:63-70. https://doi.org/10.1016/j.dcn.2015.08.007

Bibtex

@article{c93127606dba4b038e5d68aaf31d86f5,
title = "Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat",
abstract = "Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n=70) of 14-year olds with a history of cannabis use to a group (n=70) of never-using controls matched on numerous characteristics including IQ, SES, alcohol and cigarette use. The task contained short movies displaying angry and neutral faces. Results indicated that cannabis users had greater reactivity in the bilateral amygdalae to angry faces than neutral faces, an effect that was not observed in their abstinent peers. In contrast, activity levels in the cannabis users in cortical areas including the right temporal-parietal junction and bilateral dorsolateral prefrontal cortex did not discriminate between the two face conditions, but did differ in controls. Results did not change after excluding subjects with any psychiatric symptomology. Given the high density of cannabinoid receptors in the amygdala, our findings suggest cannabis use in early adolescence is associated with hypersensitivity to signals of threat. Hypersensitivity to negative affect in adolescence may place the subject at-risk for mood disorders in adulthood.",
author = "Spechler, {Philip A} and Orr, {Catherine A} and Bader Chaarani and Kees-Jan Kan and Scott Mackey and Aaron Morton and Snowe, {Mitchell P} and Hudson, {Kelsey E} and Althoff, {Robert R} and Higgins, {Stephen T} and Anna Cattrell and Herta Flor and Frauke Nees and Tobias Banaschewski and Bokde, {Arun L W} and Robert Whelan and Christian B{\"u}chel and Uli Bromberg and Patricia Conrod and Vincent Frouin and Dimitri Papadopoulos and Jurgen Gallinat and Andreas Heinz and Henrik Walter and Bernd Ittermann and Penny Gowland and Tom{\'a}{\v s} Paus and Luise Poustka and Jean-Luc Martinot and Eric Artiges and Smolka, {Michael N} and Gunter Schumann and Hugh Garavan and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2015. Published by Elsevier Ltd.",
year = "2015",
month = dec,
doi = "10.1016/j.dcn.2015.08.007",
language = "English",
volume = "16",
pages = "63--70",
journal = "DEV COGN NEUROS-NETH",
issn = "1878-9293",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Cannabis use in early adolescence: Evidence of amygdala hypersensitivity to signals of threat

AU - Spechler, Philip A

AU - Orr, Catherine A

AU - Chaarani, Bader

AU - Kan, Kees-Jan

AU - Mackey, Scott

AU - Morton, Aaron

AU - Snowe, Mitchell P

AU - Hudson, Kelsey E

AU - Althoff, Robert R

AU - Higgins, Stephen T

AU - Cattrell, Anna

AU - Flor, Herta

AU - Nees, Frauke

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Whelan, Robert

AU - Büchel, Christian

AU - Bromberg, Uli

AU - Conrod, Patricia

AU - Frouin, Vincent

AU - Papadopoulos, Dimitri

AU - Gallinat, Jurgen

AU - Heinz, Andreas

AU - Walter, Henrik

AU - Ittermann, Bernd

AU - Gowland, Penny

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Martinot, Jean-Luc

AU - Artiges, Eric

AU - Smolka, Michael N

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - IMAGEN Consortium

N1 - Copyright © 2015. Published by Elsevier Ltd.

PY - 2015/12

Y1 - 2015/12

N2 - Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n=70) of 14-year olds with a history of cannabis use to a group (n=70) of never-using controls matched on numerous characteristics including IQ, SES, alcohol and cigarette use. The task contained short movies displaying angry and neutral faces. Results indicated that cannabis users had greater reactivity in the bilateral amygdalae to angry faces than neutral faces, an effect that was not observed in their abstinent peers. In contrast, activity levels in the cannabis users in cortical areas including the right temporal-parietal junction and bilateral dorsolateral prefrontal cortex did not discriminate between the two face conditions, but did differ in controls. Results did not change after excluding subjects with any psychiatric symptomology. Given the high density of cannabinoid receptors in the amygdala, our findings suggest cannabis use in early adolescence is associated with hypersensitivity to signals of threat. Hypersensitivity to negative affect in adolescence may place the subject at-risk for mood disorders in adulthood.

AB - Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n=70) of 14-year olds with a history of cannabis use to a group (n=70) of never-using controls matched on numerous characteristics including IQ, SES, alcohol and cigarette use. The task contained short movies displaying angry and neutral faces. Results indicated that cannabis users had greater reactivity in the bilateral amygdalae to angry faces than neutral faces, an effect that was not observed in their abstinent peers. In contrast, activity levels in the cannabis users in cortical areas including the right temporal-parietal junction and bilateral dorsolateral prefrontal cortex did not discriminate between the two face conditions, but did differ in controls. Results did not change after excluding subjects with any psychiatric symptomology. Given the high density of cannabinoid receptors in the amygdala, our findings suggest cannabis use in early adolescence is associated with hypersensitivity to signals of threat. Hypersensitivity to negative affect in adolescence may place the subject at-risk for mood disorders in adulthood.

U2 - 10.1016/j.dcn.2015.08.007

DO - 10.1016/j.dcn.2015.08.007

M3 - SCORING: Journal article

C2 - 26347227

VL - 16

SP - 63

EP - 70

JO - DEV COGN NEUROS-NETH

JF - DEV COGN NEUROS-NETH

SN - 1878-9293

ER -