Research ExplorerPublicationsCan resistance training impact MRI outcomes in relapsing-rem...

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Standard

Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? / Kjølhede, Tue; Siemonsen, Susanne; Wenzel, Damian; Stellmann, Jan-Patrick; Ringgaard, Steffen; Pedersen, Bodil Ginnerup; Stenager, Egon; Petersen, Thor; Vissing, Kristian; Heesen, Christoph; Dalgas, Ulrik.

In: MULT SCLER J, Vol. 24, No. 10, 09.2018, p. 1356-1365.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kjølhede, T, Siemonsen, S, Wenzel, D, Stellmann, J-P, Ringgaard, S, Pedersen, BG, Stenager, E, Petersen, T, Vissing, K, Heesen, C & Dalgas, U 2018, 'Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?', MULT SCLER J, vol. 24, no. 10, pp. 1356-1365. https://doi.org/10.1177/1352458517722645

APA

Kjølhede, T., Siemonsen, S., Wenzel, D., Stellmann, J-P., Ringgaard, S., Pedersen, B. G., Stenager, E., Petersen, T., Vissing, K., Heesen, C., & Dalgas, U. (2018). Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? MULT SCLER J, 24(10), 1356-1365. https://doi.org/10.1177/1352458517722645

Vancouver

Kjølhede T, Siemonsen S, Wenzel D, Stellmann J-P, Ringgaard S, Pedersen BG et al. Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? MULT SCLER J. 2018 Sep;24(10):1356-1365. https://doi.org/10.1177/1352458517722645

Bibtex

@article{312ba984b4734d73bdea58d4083cd174,
title = "Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?",
abstract = "BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations.OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS.METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness).RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus.CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.",
keywords = "Journal Article",
author = "Tue Kj{\o}lhede and Susanne Siemonsen and Damian Wenzel and Jan-Patrick Stellmann and Steffen Ringgaard and Pedersen, {Bodil Ginnerup} and Egon Stenager and Thor Petersen and Kristian Vissing and Christoph Heesen and Ulrik Dalgas",
year = "2018",
month = sep,
doi = "10.1177/1352458517722645",
language = "English",
volume = "24",
pages = "1356--1365",
journal = "MULT SCLER J",
issn = "1352-4585",
publisher = "SAGE Publications",
number = "10",

}

RIS

TY - JOUR

T1 - Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

AU - Kjølhede, Tue

AU - Siemonsen, Susanne

AU - Wenzel, Damian

AU - Stellmann, Jan-Patrick

AU - Ringgaard, Steffen

AU - Pedersen, Bodil Ginnerup

AU - Stenager, Egon

AU - Petersen, Thor

AU - Vissing, Kristian

AU - Heesen, Christoph

AU - Dalgas, Ulrik

PY - 2018/9

Y1 - 2018/9

N2 - BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations.OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS.METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness).RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus.CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.

AB - BACKGROUND: Multiple sclerosis (MS) is characterised by accelerated brain atrophy, which relates to disease progression. Previous research shows that progressive resistance training (PRT) can counteract brain atrophy in other populations.OBJECTIVE: To evaluate the effects of PRT by magnetic resonance imaging (MRI) and clinical measures of disease progression in people with MS.METHODS: This study was a 24-week randomised controlled cross-over trial, including a Training ( n = 18, 24 weeks of PRT followed by self-guided physical activity) and Waitlist group ( n = 17, 24 weeks of habitual lifestyle followed by PRT). Assessments included disability measures and MRI (lesion load, global brain volume, percentage brain volume change (PBVC) and cortical thickness).RESULTS: While the MS Functional Composite score improved, Expanded Disability Status Scale, lesion load and global brain volumes did not differ between groups. PBVC tended to differ between groups and higher absolute cortical thickness values were observed in 19 of 74 investigated cortical regions after PRT. Observed changes were confirmed and reproduced when comparing relative cortical thickness changes between groups for four areas: anterior cingulate gyrus, temporal pole, orbital sulcus and inferior temporal sulcus.CONCLUSION: PRT seem to induce an increase in cortical thickness, indicating that PRT have a neuroprotective or even neuroregenerative effect in relapsing-remitting MS.

KW - Journal Article

U2 - 10.1177/1352458517722645

DO - 10.1177/1352458517722645

M3 - SCORING: Journal article

C2 - 28752800

VL - 24

SP - 1356

EP - 1365

JO - MULT SCLER J

JF - MULT SCLER J

SN - 1352-4585

IS - 10

ER -