Calcium mobilizing second messengers derived from NAD
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Calcium mobilizing second messengers derived from NAD. / Guse, Andreas H.
In: BBA-PROTEINS PROTEOM, Vol. 1854, No. 9, 01.09.2015, p. 1132-1137.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Calcium mobilizing second messengers derived from NAD
AU - Guse, Andreas H
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Nicotinamide adenine dinucleotide (NAD) has been known since a long period of time as co-factor of oxidoreductases. However, in the past couple of decades further roles have been assigned to NAD. Here, metabolism of NAD to the Ca(2+) mobilizing second messengers cyclic adenosine diphosphoribose, nicotinic acid adenine dinucleotide phosphate and adenosine diphosphoribose is reviewed. Moreover, the mechanisms of Ca(2+) mobilization by these adenine nucleotides and their putative target Ca(2+) channels, ryanodine receptors and transient receptor potential channels are discussed. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.
AB - Nicotinamide adenine dinucleotide (NAD) has been known since a long period of time as co-factor of oxidoreductases. However, in the past couple of decades further roles have been assigned to NAD. Here, metabolism of NAD to the Ca(2+) mobilizing second messengers cyclic adenosine diphosphoribose, nicotinic acid adenine dinucleotide phosphate and adenosine diphosphoribose is reviewed. Moreover, the mechanisms of Ca(2+) mobilization by these adenine nucleotides and their putative target Ca(2+) channels, ryanodine receptors and transient receptor potential channels are discussed. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications.
U2 - 10.1016/j.bbapap.2014.12.015
DO - 10.1016/j.bbapap.2014.12.015
M3 - SCORING: Journal article
C2 - 25534250
VL - 1854
SP - 1132
EP - 1137
JO - BBA-PROTEINS PROTEOM
JF - BBA-PROTEINS PROTEOM
SN - 1570-9639
IS - 9
ER -