Calcium homeostasis influences radiological fracture healing in postmenopausal women

J P Kolb; A F Schilling; J Bischoff; A Novo de Oliveira; A Spiro; M Hoffmann; M Amling; J M Rueger; W Lehmann

doi:10.1007/s00402-012-1650-0

Calcium homeostasis influences radiological fracture healing in postmenopausal women

Standard

Calcium homeostasis influences radiological fracture healing in postmenopausal women. / Kolb, J P; Schilling, A F; Bischoff, J; Novo de Oliveira, A; Spiro, A; Hoffmann, M; Amling, M; Rueger, J M; Lehmann, W.

In: ARCH ORTHOP TRAUM SU, Vol. 133, No. 2, 01.02.2013, p. 187-92.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kolb, JP, Schilling, AF, Bischoff, J, Novo de Oliveira, A, Spiro, A, Hoffmann, M, Amling, M, Rueger, JM & Lehmann, W 2013, 'Calcium homeostasis influences radiological fracture healing in postmenopausal women', ARCH ORTHOP TRAUM SU, vol. 133, no. 2, pp. 187-92. https://doi.org/10.1007/s00402-012-1650-0

APA

Kolb, J. P., Schilling, A. F., Bischoff, J., Novo de Oliveira, A., Spiro, A., Hoffmann, M., Amling, M., Rueger, J. M., & Lehmann, W. (2013). Calcium homeostasis influences radiological fracture healing in postmenopausal women. ARCH ORTHOP TRAUM SU, 133(2), 187-92. https://doi.org/10.1007/s00402-012-1650-0

Vancouver

Kolb JP, Schilling AF, Bischoff J, Novo de Oliveira A, Spiro A, Hoffmann M et al. Calcium homeostasis influences radiological fracture healing in postmenopausal women. ARCH ORTHOP TRAUM SU. 2013 Feb 1;133(2):187-92. https://doi.org/10.1007/s00402-012-1650-0

Bibtex

@article{8d989935de9a4ed0849ae09c0c140d9c,

title = "Calcium homeostasis influences radiological fracture healing in postmenopausal women",

abstract = "INTRODUCTION: Recent studies suggest that calcium and 25-[OH]-cholecalciferol represent substantial co-factors in fracture healing. However, there still seems to be no sustainable consensus regarding the influence on fracture healing patterns. In this study, the influence of calcium and vitamin D levels on fracture callus formation was prospectively analysed using pQCT scan.METHODS: 94 postmenopausal females with distal radius fractures and consecutive surgery were included. Calcium, 25-[OH]-cholecalciferol, parathyroid hormone and bone-specific alkaline phosphatase levels were obtained prior surgical treatment and after 6 weeks. A pQCT scan was performed on both sites. Bone mineral density and fracture callus area were determined after detecting the outer border contour at a threshold of 280 mg/ccm. Patients received daily supplements of 1000 mg calcium and 880 IU 25-[OH]-cholecalciferol.RESULTS: Mean 25-[OH]-cholecalciferol level was 19.61 ± 21.87 ng/ml, mean parathyroid hormone level was 52.6 ± 58.9 ng/l and mean Ca level was 2.23 ± 0.35 mmol/l. After 6 weeks of supplementation a significant increase of calcium (p < 0.001) and 25-[OH]-cholecalciferol (p < 0.001), and a significant decrease of parathyroid hormone (p < 0.001) levels were observed. Sixth week follow-up fracture callus area correlated significantly with postoperative normal range calcium levels on the fractured site (p = 0.006). Bone mineral density correlated with age (p < 0.001), but not with calcium and 25-[OH]-cholecalciferol levels after 6 weeks. All fractures presented timely adequate callus formation.CONCLUSION: Calcium and parathyroid hormone serum levels influence fracture callus area interpreted as fracture callus formation patterns. Calcium levels within physiological range accounted for highest fracture callus area. Therefore, a balanced calcium homeostasis is required for appropriate callus formation.",

keywords = "Aged, Aged, 80 and over, Alkaline Phosphatase, Bone Density, Bony Callus, Calcifediol, Calcium, Dietary Supplements, Female, Fracture Healing, Homeostasis, Humans, Middle Aged, Parathyroid Hormone, Postmenopause, Radius Fractures, Tomography, X-Ray Computed",

author = "Kolb, {J P} and Schilling, {A F} and J Bischoff and {Novo de Oliveira}, A and A Spiro and M Hoffmann and M Amling and Rueger, {J M} and W Lehmann",

year = "2013",

month = feb,

day = "1",

doi = "10.1007/s00402-012-1650-0",

language = "English",

volume = "133",

pages = "187--92",

journal = "ARCH ORTHOP TRAUM SU",

issn = "0936-8051",

publisher = "Springer",

number = "2",

}

RIS

TY - JOUR

T1 - Calcium homeostasis influences radiological fracture healing in postmenopausal women

AU - Kolb, J P

AU - Schilling, A F

AU - Bischoff, J

AU - Novo de Oliveira, A

AU - Spiro, A

AU - Hoffmann, M

AU - Amling, M

AU - Rueger, J M

AU - Lehmann, W

PY - 2013/2/1

Y1 - 2013/2/1

N2 - INTRODUCTION: Recent studies suggest that calcium and 25-[OH]-cholecalciferol represent substantial co-factors in fracture healing. However, there still seems to be no sustainable consensus regarding the influence on fracture healing patterns. In this study, the influence of calcium and vitamin D levels on fracture callus formation was prospectively analysed using pQCT scan.METHODS: 94 postmenopausal females with distal radius fractures and consecutive surgery were included. Calcium, 25-[OH]-cholecalciferol, parathyroid hormone and bone-specific alkaline phosphatase levels were obtained prior surgical treatment and after 6 weeks. A pQCT scan was performed on both sites. Bone mineral density and fracture callus area were determined after detecting the outer border contour at a threshold of 280 mg/ccm. Patients received daily supplements of 1000 mg calcium and 880 IU 25-[OH]-cholecalciferol.RESULTS: Mean 25-[OH]-cholecalciferol level was 19.61 ± 21.87 ng/ml, mean parathyroid hormone level was 52.6 ± 58.9 ng/l and mean Ca level was 2.23 ± 0.35 mmol/l. After 6 weeks of supplementation a significant increase of calcium (p < 0.001) and 25-[OH]-cholecalciferol (p < 0.001), and a significant decrease of parathyroid hormone (p < 0.001) levels were observed. Sixth week follow-up fracture callus area correlated significantly with postoperative normal range calcium levels on the fractured site (p = 0.006). Bone mineral density correlated with age (p < 0.001), but not with calcium and 25-[OH]-cholecalciferol levels after 6 weeks. All fractures presented timely adequate callus formation.CONCLUSION: Calcium and parathyroid hormone serum levels influence fracture callus area interpreted as fracture callus formation patterns. Calcium levels within physiological range accounted for highest fracture callus area. Therefore, a balanced calcium homeostasis is required for appropriate callus formation.

AB - INTRODUCTION: Recent studies suggest that calcium and 25-[OH]-cholecalciferol represent substantial co-factors in fracture healing. However, there still seems to be no sustainable consensus regarding the influence on fracture healing patterns. In this study, the influence of calcium and vitamin D levels on fracture callus formation was prospectively analysed using pQCT scan.METHODS: 94 postmenopausal females with distal radius fractures and consecutive surgery were included. Calcium, 25-[OH]-cholecalciferol, parathyroid hormone and bone-specific alkaline phosphatase levels were obtained prior surgical treatment and after 6 weeks. A pQCT scan was performed on both sites. Bone mineral density and fracture callus area were determined after detecting the outer border contour at a threshold of 280 mg/ccm. Patients received daily supplements of 1000 mg calcium and 880 IU 25-[OH]-cholecalciferol.RESULTS: Mean 25-[OH]-cholecalciferol level was 19.61 ± 21.87 ng/ml, mean parathyroid hormone level was 52.6 ± 58.9 ng/l and mean Ca level was 2.23 ± 0.35 mmol/l. After 6 weeks of supplementation a significant increase of calcium (p < 0.001) and 25-[OH]-cholecalciferol (p < 0.001), and a significant decrease of parathyroid hormone (p < 0.001) levels were observed. Sixth week follow-up fracture callus area correlated significantly with postoperative normal range calcium levels on the fractured site (p = 0.006). Bone mineral density correlated with age (p < 0.001), but not with calcium and 25-[OH]-cholecalciferol levels after 6 weeks. All fractures presented timely adequate callus formation.CONCLUSION: Calcium and parathyroid hormone serum levels influence fracture callus area interpreted as fracture callus formation patterns. Calcium levels within physiological range accounted for highest fracture callus area. Therefore, a balanced calcium homeostasis is required for appropriate callus formation.

KW - Aged

KW - Aged, 80 and over

KW - Alkaline Phosphatase

KW - Bone Density

KW - Bony Callus

KW - Calcifediol

KW - Calcium

KW - Dietary Supplements

KW - Female

KW - Fracture Healing

KW - Homeostasis

KW - Humans

KW - Middle Aged

KW - Parathyroid Hormone

KW - Postmenopause

KW - Radius Fractures

KW - Tomography, X-Ray Computed

U2 - 10.1007/s00402-012-1650-0

DO - 10.1007/s00402-012-1650-0

M3 - SCORING: Journal article

C2 - 23179475

VL - 133

SP - 187

EP - 192

JO - ARCH ORTHOP TRAUM SU

JF - ARCH ORTHOP TRAUM SU

SN - 0936-8051

IS - 2

ER -