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CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target

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CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target. / Drenckhan, Astrid; Freytag, Morton; Supuran, Claudiu T; Sauter, Guido; Izbicki, Jakob R; Gros, Stephanie J.

In: J ENZYM INHIB MED CH, Vol. 33, No. 1, 06.2018, p. 1024-1033.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Drenckhan, A, Freytag, M, Supuran, CT, Sauter, G, Izbicki, JR & Gros, SJ 2018, 'CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target', J ENZYM INHIB MED CH, vol. 33, no. 1, pp. 1024-1033. https://doi.org/10.1080/14756366.2018.1475369

APA

Drenckhan, A., Freytag, M., Supuran, C. T., Sauter, G., Izbicki, J. R., & Gros, S. J. (2018). CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target. J ENZYM INHIB MED CH, 33(1), 1024-1033. https://doi.org/10.1080/14756366.2018.1475369

Vancouver

Drenckhan A, Freytag M, Supuran CT, Sauter G, Izbicki JR, Gros SJ. CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target. J ENZYM INHIB MED CH. 2018 Jun;33(1):1024-1033. https://doi.org/10.1080/14756366.2018.1475369

Bibtex

@article{c1ea1f32ebaf4598923a2cc27fa16380,
title = "CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target",
abstract = "The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under hypoxia. We show that CAIX is strongly expressed in esophageal carcinoma tissues. We hypothesize that a moderate CAIX expression facilitates metastases and thereby worsens prognosis. Selective inhibition of CAIX by specific CAIX inhibitors and a CAIX knockdown effectively inhibit proliferation and migration in vitro. In the orthotopic esophageal carcinoma model, the humanized HER2 antibody trastuzumab down-regulates CAIX, possibly through CAIX's linkage with HER2 in the hypoxic microenvironment. Our results show CAIX to be an essential part of the tumour microenvironment and a possible master regulator of tumour progression. This makes CAIX a highly effective and feasible therapeutic target for selective cancer treatment.",
keywords = "Antigens, Neoplasm, Antineoplastic Agents, Carbonic Anhydrase IX, Carbonic Anhydrase Inhibitors, Cell Movement, Cell Proliferation, Disease Progression, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Esophageal Neoplasms, Female, Humans, Hypoxia, Male, Middle Aged, Molecular Structure, Structure-Activity Relationship, Tissue Array Analysis, Tumor Cells, Cultured, Tumor Microenvironment, Journal Article",
author = "Astrid Drenckhan and Morton Freytag and Supuran, {Claudiu T} and Guido Sauter and Izbicki, {Jakob R} and Gros, {Stephanie J}",
year = "2018",
month = jun,
doi = "10.1080/14756366.2018.1475369",
language = "English",
volume = "33",
pages = "1024--1033",
journal = "J ENZYM INHIB MED CH",
issn = "1475-6366",
publisher = "informa healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - CAIX furthers tumour progression in the hypoxic tumour microenvironment of esophageal carcinoma and is a possible therapeutic target

AU - Drenckhan, Astrid

AU - Freytag, Morton

AU - Supuran, Claudiu T

AU - Sauter, Guido

AU - Izbicki, Jakob R

AU - Gros, Stephanie J

PY - 2018/6

Y1 - 2018/6

N2 - The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under hypoxia. We show that CAIX is strongly expressed in esophageal carcinoma tissues. We hypothesize that a moderate CAIX expression facilitates metastases and thereby worsens prognosis. Selective inhibition of CAIX by specific CAIX inhibitors and a CAIX knockdown effectively inhibit proliferation and migration in vitro. In the orthotopic esophageal carcinoma model, the humanized HER2 antibody trastuzumab down-regulates CAIX, possibly through CAIX's linkage with HER2 in the hypoxic microenvironment. Our results show CAIX to be an essential part of the tumour microenvironment and a possible master regulator of tumour progression. This makes CAIX a highly effective and feasible therapeutic target for selective cancer treatment.

AB - The hypoxic tumour microenvironment of solid tumours represents an important starting point for modulating progression and metastatic spread. Carbonic anhydrase IX (CAIX) is a known HIF-1α-dependent key player in maintaining cell pH conditions under hypoxia. We show that CAIX is strongly expressed in esophageal carcinoma tissues. We hypothesize that a moderate CAIX expression facilitates metastases and thereby worsens prognosis. Selective inhibition of CAIX by specific CAIX inhibitors and a CAIX knockdown effectively inhibit proliferation and migration in vitro. In the orthotopic esophageal carcinoma model, the humanized HER2 antibody trastuzumab down-regulates CAIX, possibly through CAIX's linkage with HER2 in the hypoxic microenvironment. Our results show CAIX to be an essential part of the tumour microenvironment and a possible master regulator of tumour progression. This makes CAIX a highly effective and feasible therapeutic target for selective cancer treatment.

KW - Antigens, Neoplasm

KW - Antineoplastic Agents

KW - Carbonic Anhydrase IX

KW - Carbonic Anhydrase Inhibitors

KW - Cell Movement

KW - Cell Proliferation

KW - Disease Progression

KW - Dose-Response Relationship, Drug

KW - Drug Screening Assays, Antitumor

KW - Esophageal Neoplasms

KW - Female

KW - Humans

KW - Hypoxia

KW - Male

KW - Middle Aged

KW - Molecular Structure

KW - Structure-Activity Relationship

KW - Tissue Array Analysis

KW - Tumor Cells, Cultured

KW - Tumor Microenvironment

KW - Journal Article

U2 - 10.1080/14756366.2018.1475369

DO - 10.1080/14756366.2018.1475369

M3 - SCORING: Journal article

C2 - 29865880

VL - 33

SP - 1024

EP - 1033

JO - J ENZYM INHIB MED CH

JF - J ENZYM INHIB MED CH

SN - 1475-6366

IS - 1

ER -