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Ca2+ ATPase activity in essential and renal hypertension

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Ca2+ ATPase activity in essential and renal hypertension. / Spieker, C; Pan, N; Schlüter, H; Zidek, W.

In: CLIN EXP HYPERTENS, Vol. 15, No. 1, 01.1993, p. 143-52.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Spieker, C, Pan, N, Schlüter, H & Zidek, W 1993, 'Ca2+ ATPase activity in essential and renal hypertension', CLIN EXP HYPERTENS, vol. 15, no. 1, pp. 143-52.

APA

Spieker, C., Pan, N., Schlüter, H., & Zidek, W. (1993). Ca2+ ATPase activity in essential and renal hypertension. CLIN EXP HYPERTENS, 15(1), 143-52.

Vancouver

Spieker C, Pan N, Schlüter H, Zidek W. Ca2+ ATPase activity in essential and renal hypertension. CLIN EXP HYPERTENS. 1993 Jan;15(1):143-52.

Bibtex

@article{21aa4dcec25143c0b726d1a5647df24c,
title = "Ca2+ ATPase activity in essential and renal hypertension",
abstract = "In 15 patients with essential hypertension, 16 patients with renal hypertension and in 12 healthy subjects Ca2+ ATPase activity was determined in red blood cells both in the basal state and after maximal stimulation with calmodulin. Normal subjects showed a basal and maximal activity of 7.1 +/- 3.6 and 16.0 +/- 2.3 pmol phosphate/min.10(6) RBC, respectively. Renal hypertensives had a similar basal Ca2+ ATPase activity (5.4 +/- 4.1 pmol phosphate/min.10(6) RBC) and a lowered maximal Ca2+ ATPase activity (9.8 +/- 5.4 pmol phosphate/min.10(6) RBC, p < 0.05). In essential hypertensives basal and maximal Ca2+ ATPase activity was 9.0 +/- 5.3 and 35.4 +/- 14.4 pmol phosphate/min.10(6) RBC, respectively, the latter being significantly increased (p < 0.01). This finding, which is in contrast to earlier results indicating a lowered Ca2+ ATPase activity in essential hypertension, may be explained as a consequence of an increased Ca2+ influx in essential hypertension. A lowered Ca2+ ATPase activity does not seem to be involved in the pathogenesis of essential hypertension.",
keywords = "Adult, Calcium, Calcium-Transporting ATPases, Calmodulin, Erythrocytes, Female, Humans, Hypertension, Hypertension, Renal, In Vitro Techniques, Male, Middle Aged, Journal Article",
author = "C Spieker and N Pan and H Schl{\"u}ter and W Zidek",
year = "1993",
month = jan,
language = "English",
volume = "15",
pages = "143--52",
journal = "CLIN EXP HYPERTENS",
issn = "1064-1963",
publisher = "informa healthcare",
number = "1",

}

RIS

TY - JOUR

T1 - Ca2+ ATPase activity in essential and renal hypertension

AU - Spieker, C

AU - Pan, N

AU - Schlüter, H

AU - Zidek, W

PY - 1993/1

Y1 - 1993/1

N2 - In 15 patients with essential hypertension, 16 patients with renal hypertension and in 12 healthy subjects Ca2+ ATPase activity was determined in red blood cells both in the basal state and after maximal stimulation with calmodulin. Normal subjects showed a basal and maximal activity of 7.1 +/- 3.6 and 16.0 +/- 2.3 pmol phosphate/min.10(6) RBC, respectively. Renal hypertensives had a similar basal Ca2+ ATPase activity (5.4 +/- 4.1 pmol phosphate/min.10(6) RBC) and a lowered maximal Ca2+ ATPase activity (9.8 +/- 5.4 pmol phosphate/min.10(6) RBC, p < 0.05). In essential hypertensives basal and maximal Ca2+ ATPase activity was 9.0 +/- 5.3 and 35.4 +/- 14.4 pmol phosphate/min.10(6) RBC, respectively, the latter being significantly increased (p < 0.01). This finding, which is in contrast to earlier results indicating a lowered Ca2+ ATPase activity in essential hypertension, may be explained as a consequence of an increased Ca2+ influx in essential hypertension. A lowered Ca2+ ATPase activity does not seem to be involved in the pathogenesis of essential hypertension.

AB - In 15 patients with essential hypertension, 16 patients with renal hypertension and in 12 healthy subjects Ca2+ ATPase activity was determined in red blood cells both in the basal state and after maximal stimulation with calmodulin. Normal subjects showed a basal and maximal activity of 7.1 +/- 3.6 and 16.0 +/- 2.3 pmol phosphate/min.10(6) RBC, respectively. Renal hypertensives had a similar basal Ca2+ ATPase activity (5.4 +/- 4.1 pmol phosphate/min.10(6) RBC) and a lowered maximal Ca2+ ATPase activity (9.8 +/- 5.4 pmol phosphate/min.10(6) RBC, p < 0.05). In essential hypertensives basal and maximal Ca2+ ATPase activity was 9.0 +/- 5.3 and 35.4 +/- 14.4 pmol phosphate/min.10(6) RBC, respectively, the latter being significantly increased (p < 0.01). This finding, which is in contrast to earlier results indicating a lowered Ca2+ ATPase activity in essential hypertension, may be explained as a consequence of an increased Ca2+ influx in essential hypertension. A lowered Ca2+ ATPase activity does not seem to be involved in the pathogenesis of essential hypertension.

KW - Adult

KW - Calcium

KW - Calcium-Transporting ATPases

KW - Calmodulin

KW - Erythrocytes

KW - Female

KW - Humans

KW - Hypertension

KW - Hypertension, Renal

KW - In Vitro Techniques

KW - Male

KW - Middle Aged

KW - Journal Article

M3 - SCORING: Journal article

C2 - 8467309

VL - 15

SP - 143

EP - 152

JO - CLIN EXP HYPERTENS

JF - CLIN EXP HYPERTENS

SN - 1064-1963

IS - 1

ER -