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Burden of influenza among hospitalized febrile children in Ghana

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Burden of influenza among hospitalized febrile children in Ghana. / Hogan, Benedikt; Ammer, Luise; Zimmermann, Marlow; Binger, Tabea; Krumkamp, Ralf; Sarpong, Nimako; Rettig, Theresa; Dekker, Denise; Kreuels, Benno; Reigl, Lisa; Boahen, Kennedy G; Wiafe, Charity; Adu-Sarkodie, Yaw; Owusu-Dabo, Ellis; May, Jürgen; Eibach, Daniel.

In: INFLUENZA OTHER RESP, Vol. 11, No. 6, 11.2017, p. 497-501.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hogan, B, Ammer, L, Zimmermann, M, Binger, T, Krumkamp, R, Sarpong, N, Rettig, T, Dekker, D, Kreuels, B, Reigl, L, Boahen, KG, Wiafe, C, Adu-Sarkodie, Y, Owusu-Dabo, E, May, J & Eibach, D 2017, 'Burden of influenza among hospitalized febrile children in Ghana', INFLUENZA OTHER RESP, vol. 11, no. 6, pp. 497-501. https://doi.org/10.1111/irv.12507

APA

Hogan, B., Ammer, L., Zimmermann, M., Binger, T., Krumkamp, R., Sarpong, N., Rettig, T., Dekker, D., Kreuels, B., Reigl, L., Boahen, K. G., Wiafe, C., Adu-Sarkodie, Y., Owusu-Dabo, E., May, J., & Eibach, D. (2017). Burden of influenza among hospitalized febrile children in Ghana. INFLUENZA OTHER RESP, 11(6), 497-501. https://doi.org/10.1111/irv.12507

Vancouver

Hogan B, Ammer L, Zimmermann M, Binger T, Krumkamp R, Sarpong N et al. Burden of influenza among hospitalized febrile children in Ghana. INFLUENZA OTHER RESP. 2017 Nov;11(6):497-501. https://doi.org/10.1111/irv.12507

Bibtex

@article{03e315614c7d45f6931dd4f5c10b942e,
title = "Burden of influenza among hospitalized febrile children in Ghana",
abstract = "BACKGROUND: Influenza surveillance data from Africa indicate a substantial disease burden with high mortality. However, local influenza data from district hospitals with limited laboratory facilities are still scarce.OBJECTIVES: To identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.METHODS: Between January 2014 and April 2015, all children with a temperature of ≥38°C admitted to a district hospital in Ghana were screened for influenza A and B by RT-PCR and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.RESULTS: A total of 1063 children with a median age of 2 years (IQR: 1-4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (SARI) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09, and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3-5 years and was more frequently detected in the major rainy season (OR = 2.9; 95% CI: 1.47-6.19) during the first half of the year. Two (4%) and seven (15%) influenza-positive children were co-diagnosed with an invasive bloodstream infection or malaria, respectively.CONCLUSION: Influenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half-year.",
keywords = "Journal Article",
author = "Benedikt Hogan and Luise Ammer and Marlow Zimmermann and Tabea Binger and Ralf Krumkamp and Nimako Sarpong and Theresa Rettig and Denise Dekker and Benno Kreuels and Lisa Reigl and Boahen, {Kennedy G} and Charity Wiafe and Yaw Adu-Sarkodie and Ellis Owusu-Dabo and J{\"u}rgen May and Daniel Eibach",
note = "{\textcopyright} 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.",
year = "2017",
month = nov,
doi = "10.1111/irv.12507",
language = "English",
volume = "11",
pages = "497--501",
journal = "INFLUENZA OTHER RESP",
issn = "1750-2640",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Burden of influenza among hospitalized febrile children in Ghana

AU - Hogan, Benedikt

AU - Ammer, Luise

AU - Zimmermann, Marlow

AU - Binger, Tabea

AU - Krumkamp, Ralf

AU - Sarpong, Nimako

AU - Rettig, Theresa

AU - Dekker, Denise

AU - Kreuels, Benno

AU - Reigl, Lisa

AU - Boahen, Kennedy G

AU - Wiafe, Charity

AU - Adu-Sarkodie, Yaw

AU - Owusu-Dabo, Ellis

AU - May, Jürgen

AU - Eibach, Daniel

N1 - © 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.

PY - 2017/11

Y1 - 2017/11

N2 - BACKGROUND: Influenza surveillance data from Africa indicate a substantial disease burden with high mortality. However, local influenza data from district hospitals with limited laboratory facilities are still scarce.OBJECTIVES: To identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.METHODS: Between January 2014 and April 2015, all children with a temperature of ≥38°C admitted to a district hospital in Ghana were screened for influenza A and B by RT-PCR and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.RESULTS: A total of 1063 children with a median age of 2 years (IQR: 1-4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (SARI) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09, and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3-5 years and was more frequently detected in the major rainy season (OR = 2.9; 95% CI: 1.47-6.19) during the first half of the year. Two (4%) and seven (15%) influenza-positive children were co-diagnosed with an invasive bloodstream infection or malaria, respectively.CONCLUSION: Influenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half-year.

AB - BACKGROUND: Influenza surveillance data from Africa indicate a substantial disease burden with high mortality. However, local influenza data from district hospitals with limited laboratory facilities are still scarce.OBJECTIVES: To identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.METHODS: Between January 2014 and April 2015, all children with a temperature of ≥38°C admitted to a district hospital in Ghana were screened for influenza A and B by RT-PCR and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.RESULTS: A total of 1063 children with a median age of 2 years (IQR: 1-4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (SARI) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09, and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3-5 years and was more frequently detected in the major rainy season (OR = 2.9; 95% CI: 1.47-6.19) during the first half of the year. Two (4%) and seven (15%) influenza-positive children were co-diagnosed with an invasive bloodstream infection or malaria, respectively.CONCLUSION: Influenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half-year.

KW - Journal Article

U2 - 10.1111/irv.12507

DO - 10.1111/irv.12507

M3 - SCORING: Journal article

C2 - 28991406

VL - 11

SP - 497

EP - 501

JO - INFLUENZA OTHER RESP

JF - INFLUENZA OTHER RESP

SN - 1750-2640

IS - 6

ER -