Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis.

  • Michael P Manns
  • Marek Woynarowski
  • Wolfgang Kreisel
  • Yoav Lurie
  • Christian Rust
  • Elimelech Zuckerman
  • Matthias J Bahr
  • Rainer Günther
  • Rolf W Hultcrantz
  • Ulrich Spengler
  • Ansgar W. Lohse
  • Ferenc Szalay
  • Martti Färkkilä
  • Markus Pröls
  • Christian P Strassburg

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Abstract

Autoimmune hepatitis (AIH) is a chronic liver disease associated with cirrhosis and liver failure. Corticosteroid therapy induces long-term remission but has many side effects. We compared the effects of budesonide (a steroid that is rapidly metabolized, with low systemic exposure) and prednisone, both in combination with azathioprine.

Bibliographical data

Original languageGerman
Article number4
ISSN0016-5085
Publication statusPublished - 2010
pubmed 20600032