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Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium

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Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium. / Morra, Anna; Jung, Audrey Y; Behrens, Sabine; Keeman, Renske; Ahearn, Thomas U; Anton-Cluver, Hoda; Arndt, Volker; Augustinsson, Annelie; Auvinen, Päivi K; Beane Freeman, Laura E; Becher, Heiko; Beckmann, Matthias W; Bloomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Brenner, Hermann; Briceno, Ignacio; Brucker, Sara Y; Camp, Nicola J; Campa, Daniele; Canzian, Federico; Castelao, Jose E; Chanock, Stephen J; Choi, Ji-Yeob; Clarke, Christine L; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Dӧrk, Thilo; Dunning, Alison M; Dwek, Miriam; Eccles, Diana M; Egan, Kathleen M; Evans, D Gareth; Fasching, Peter A; Flyger, Henrik; Gago-Dominguez, Manuela; Gapstur, Susan M; Garcia-Saenz, Jose A; Gaudet, Mia M; Giles, Graham G; Grip, Mervi; Guénel, Pascal; Haiman, Christopher A; Håkansson, Niclas; Hall, Per; Hamann, Ute; Han, Sileny N; Hart, Steven N; Hartman, Mikael; Heyworth, Jane S; Hoppe, Reiner; Hopper, John L; Hunter, David J; Ito, Hidemi; Jager, Agnes; Jakimovska, Milena; Jakubowska, Anna; Janni, Wolfgang; Kaaks, Rudolf; Kang, Daehee; Middha Kapoor, Pooja; Kitahara, Cari M; Koutros, Stella; Kristensen, Vessela N; Lacey, James V; Lambrechts, Diether; Le Marchand, Loic; Li, Jingmei; Lindblom, Annika; Lubiński, Jan; Lush, Michael; Mannermaa, Arto; Manoochehri, Mehdi; Margolin, Sara; Mariapun, Shivaani; Matsuo, Keitaro; Mavroudis, Dimitris; Milne, Roger L; Muranen, Taru A; Newman, William G; Noh, Dong-Young; Nordestgaard, Børge Grønne; Obi, Nadia; Olshan, Andrew F; Olsson, Håkan; Park-Simon, Tjoung-Won; Petridis, Christos; Pharoah, Paul D P; Plaseska-Karanfilska, Dijana; Presneau, Nadege; Rashid, Muhammad U; Rennert, Gad; Rennert, Hedy S; Rhenius, Valerie; Romero, Atocha; Saloustros, Emmanouil; Sawyer, Elinor J; Schneeweiss, Andreas; Schwentner, Lukas; Scott, Christopher G; Shah, Mitul; Shen, Chen-Yang; Shu, Xiao-Ou; Southey, Melissa C; Stram, Daniel O; Tamimi, Rulla M; Tapper, William; Tollenaar, Robert A E M; Tomlinson, Ian; Torres, Diana; Troester, Melissa A; Truong, Therese; Vachon, Celine M; Wang, Qin; Wang, Sophia S; Williams, Justin A; Winqvist, Robert; Wolk, Alicja; Wu, Anna H; Yoo, Keun-Young; Yu, Jyh-Cherng; Zheng, Wei; Ziogas, Argyrios; Yang, Xiaohong R; Eliassen, A Heather; Holmes, Michelle D; Garcia-Closas, Montserrat; Teo, Soo Hwang; Schmidt, Marjanka K; Chang-Claude, Jenny.

In: CANCER EPIDEM BIOMAR, Vol. 30, No. 4, 04.2021, p. 623-642.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Morra, A, Jung, AY, Behrens, S, Keeman, R, Ahearn, TU, Anton-Cluver, H, Arndt, V, Augustinsson, A, Auvinen, PK, Beane Freeman, LE, Becher, H, Beckmann, MW, Bloomqvist, C, Bojesen, SE, Bolla, MK, Brenner, H, Briceno, I, Brucker, SY, Camp, NJ, Campa, D, Canzian, F, Castelao, JE, Chanock, SJ, Choi, J-Y, Clarke, CL, Couch, FJ, Cox, A, Cross, SS, Czene, K, Dӧrk, T, Dunning, AM, Dwek, M, Eccles, DM, Egan, KM, Evans, DG, Fasching, PA, Flyger, H, Gago-Dominguez, M, Gapstur, SM, Garcia-Saenz, JA, Gaudet, MM, Giles, GG, Grip, M, Guénel, P, Haiman, CA, Håkansson, N, Hall, P, Hamann, U, Han, SN, Hart, SN, Hartman, M, Heyworth, JS, Hoppe, R, Hopper, JL, Hunter, DJ, Ito, H, Jager, A, Jakimovska, M, Jakubowska, A, Janni, W, Kaaks, R, Kang, D, Middha Kapoor, P, Kitahara, CM, Koutros, S, Kristensen, VN, Lacey, JV, Lambrechts, D, Le Marchand, L, Li, J, Lindblom, A, Lubiński, J, Lush, M, Mannermaa, A, Manoochehri, M, Margolin, S, Mariapun, S, Matsuo, K, Mavroudis, D, Milne, RL, Muranen, TA, Newman, WG, Noh, D-Y, Nordestgaard, BG, Obi, N, Olshan, AF, Olsson, H, Park-Simon, T-W, Petridis, C, Pharoah, PDP, Plaseska-Karanfilska, D, Presneau, N, Rashid, MU, Rennert, G, Rennert, HS, Rhenius, V, Romero, A, Saloustros, E, Sawyer, EJ, Schneeweiss, A, Schwentner, L, Scott, CG, Shah, M, Shen, C-Y, Shu, X-O, Southey, MC, Stram, DO, Tamimi, RM, Tapper, W, Tollenaar, RAEM, Tomlinson, I, Torres, D, Troester, MA, Truong, T, Vachon, CM, Wang, Q, Wang, SS, Williams, JA, Winqvist, R, Wolk, A, Wu, AH, Yoo, K-Y, Yu, J-C, Zheng, W, Ziogas, A, Yang, XR, Eliassen, AH, Holmes, MD, Garcia-Closas, M, Teo, SH, Schmidt, MK & Chang-Claude, J 2021, 'Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium', CANCER EPIDEM BIOMAR, vol. 30, no. 4, pp. 623-642. https://doi.org/10.1158/1055-9965.EPI-20-0924

APA

Morra, A., Jung, A. Y., Behrens, S., Keeman, R., Ahearn, T. U., Anton-Cluver, H., Arndt, V., Augustinsson, A., Auvinen, P. K., Beane Freeman, L. E., Becher, H., Beckmann, M. W., Bloomqvist, C., Bojesen, S. E., Bolla, M. K., Brenner, H., Briceno, I., Brucker, S. Y., Camp, N. J., ... Chang-Claude, J. (2021). Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium. CANCER EPIDEM BIOMAR, 30(4), 623-642. https://doi.org/10.1158/1055-9965.EPI-20-0924

Vancouver

Morra A, Jung AY, Behrens S, Keeman R, Ahearn TU, Anton-Cluver H et al. Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium. CANCER EPIDEM BIOMAR. 2021 Apr;30(4):623-642. https://doi.org/10.1158/1055-9965.EPI-20-0924

Bibtex

@article{862a69fc503b495f916179cf9b003c09,
title = "Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium",
abstract = "BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype.METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype.RESULTS: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5-25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06-1.34)]; current versus never smoking [1.37 (1.27-1.47)], high versus low physical activity [0.43 (0.21-0.86)], age ≥30 years versus <20 years at first pregnancy [0.79 (0.72-0.86)]; >0-<5 years versus ≥10 years since last full-term birth [1.31 (1.11-1.55)]; ever versus never use of oral contraceptives [0.91 (0.87-0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen-progestin therapy [0.61 (0.54-0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02-1.21) for current versus never smoking.CONCLUSIONS: We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype.IMPACT: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care.",
author = "Anna Morra and Jung, {Audrey Y} and Sabine Behrens and Renske Keeman and Ahearn, {Thomas U} and Hoda Anton-Cluver and Volker Arndt and Annelie Augustinsson and Auvinen, {P{\"a}ivi K} and {Beane Freeman}, {Laura E} and Heiko Becher and Beckmann, {Matthias W} and Carl Bloomqvist and Bojesen, {Stig E} and Bolla, {Manjeet K} and Hermann Brenner and Ignacio Briceno and Brucker, {Sara Y} and Camp, {Nicola J} and Daniele Campa and Federico Canzian and Castelao, {Jose E} and Chanock, {Stephen J} and Ji-Yeob Choi and Clarke, {Christine L} and Couch, {Fergus J} and Angela Cox and Cross, {Simon S} and Kamila Czene and Thilo Dӧrk and Dunning, {Alison M} and Miriam Dwek and Eccles, {Diana M} and Egan, {Kathleen M} and Evans, {D Gareth} and Fasching, {Peter A} and Henrik Flyger and Manuela Gago-Dominguez and Gapstur, {Susan M} and Garcia-Saenz, {Jose A} and Gaudet, {Mia M} and Giles, {Graham G} and Mervi Grip and Pascal Gu{\'e}nel and Haiman, {Christopher A} and Niclas H{\aa}kansson and Per Hall and Ute Hamann and Han, {Sileny N} and Hart, {Steven N} and Mikael Hartman and Heyworth, {Jane S} and Reiner Hoppe and Hopper, {John L} and Hunter, {David J} and Hidemi Ito and Agnes Jager and Milena Jakimovska and Anna Jakubowska and Wolfgang Janni and Rudolf Kaaks and Daehee Kang and {Middha Kapoor}, Pooja and Kitahara, {Cari M} and Stella Koutros and Kristensen, {Vessela N} and Lacey, {James V} and Diether Lambrechts and {Le Marchand}, Loic and Jingmei Li and Annika Lindblom and Jan Lubi{\'n}ski and Michael Lush and Arto Mannermaa and Mehdi Manoochehri and Sara Margolin and Shivaani Mariapun and Keitaro Matsuo and Dimitris Mavroudis and Milne, {Roger L} and Muranen, {Taru A} and Newman, {William G} and Dong-Young Noh and Nordestgaard, {B{\o}rge Gr{\o}nne} and Nadia Obi and Olshan, {Andrew F} and H{\aa}kan Olsson and Tjoung-Won Park-Simon and Christos Petridis and Pharoah, {Paul D P} and Dijana Plaseska-Karanfilska and Nadege Presneau and Rashid, {Muhammad U} and Gad Rennert and Rennert, {Hedy S} and Valerie Rhenius and Atocha Romero and Emmanouil Saloustros and Sawyer, {Elinor J} and Andreas Schneeweiss and Lukas Schwentner and Scott, {Christopher G} and Mitul Shah and Chen-Yang Shen and Xiao-Ou Shu and Southey, {Melissa C} and Stram, {Daniel O} and Tamimi, {Rulla M} and William Tapper and Tollenaar, {Robert A E M} and Ian Tomlinson and Diana Torres and Troester, {Melissa A} and Therese Truong and Vachon, {Celine M} and Qin Wang and Wang, {Sophia S} and Williams, {Justin A} and Robert Winqvist and Alicja Wolk and Wu, {Anna H} and Keun-Young Yoo and Jyh-Cherng Yu and Wei Zheng and Argyrios Ziogas and Yang, {Xiaohong R} and Eliassen, {A Heather} and Holmes, {Michelle D} and Montserrat Garcia-Closas and Teo, {Soo Hwang} and Schmidt, {Marjanka K} and Jenny Chang-Claude",
note = "Copyright {\textcopyright}2021, American Association for Cancer Research.",
year = "2021",
month = apr,
doi = "10.1158/1055-9965.EPI-20-0924",
language = "English",
volume = "30",
pages = "623--642",
journal = "CANCER EPIDEM BIOMAR",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Breast cancer risk factors and survival by tumor subtype: pooled analyses from the Breast Cancer Association Consortium

AU - Morra, Anna

AU - Jung, Audrey Y

AU - Behrens, Sabine

AU - Keeman, Renske

AU - Ahearn, Thomas U

AU - Anton-Cluver, Hoda

AU - Arndt, Volker

AU - Augustinsson, Annelie

AU - Auvinen, Päivi K

AU - Beane Freeman, Laura E

AU - Becher, Heiko

AU - Beckmann, Matthias W

AU - Bloomqvist, Carl

AU - Bojesen, Stig E

AU - Bolla, Manjeet K

AU - Brenner, Hermann

AU - Briceno, Ignacio

AU - Brucker, Sara Y

AU - Camp, Nicola J

AU - Campa, Daniele

AU - Canzian, Federico

AU - Castelao, Jose E

AU - Chanock, Stephen J

AU - Choi, Ji-Yeob

AU - Clarke, Christine L

AU - Couch, Fergus J

AU - Cox, Angela

AU - Cross, Simon S

AU - Czene, Kamila

AU - Dӧrk, Thilo

AU - Dunning, Alison M

AU - Dwek, Miriam

AU - Eccles, Diana M

AU - Egan, Kathleen M

AU - Evans, D Gareth

AU - Fasching, Peter A

AU - Flyger, Henrik

AU - Gago-Dominguez, Manuela

AU - Gapstur, Susan M

AU - Garcia-Saenz, Jose A

AU - Gaudet, Mia M

AU - Giles, Graham G

AU - Grip, Mervi

AU - Guénel, Pascal

AU - Haiman, Christopher A

AU - Håkansson, Niclas

AU - Hall, Per

AU - Hamann, Ute

AU - Han, Sileny N

AU - Hart, Steven N

AU - Hartman, Mikael

AU - Heyworth, Jane S

AU - Hoppe, Reiner

AU - Hopper, John L

AU - Hunter, David J

AU - Ito, Hidemi

AU - Jager, Agnes

AU - Jakimovska, Milena

AU - Jakubowska, Anna

AU - Janni, Wolfgang

AU - Kaaks, Rudolf

AU - Kang, Daehee

AU - Middha Kapoor, Pooja

AU - Kitahara, Cari M

AU - Koutros, Stella

AU - Kristensen, Vessela N

AU - Lacey, James V

AU - Lambrechts, Diether

AU - Le Marchand, Loic

AU - Li, Jingmei

AU - Lindblom, Annika

AU - Lubiński, Jan

AU - Lush, Michael

AU - Mannermaa, Arto

AU - Manoochehri, Mehdi

AU - Margolin, Sara

AU - Mariapun, Shivaani

AU - Matsuo, Keitaro

AU - Mavroudis, Dimitris

AU - Milne, Roger L

AU - Muranen, Taru A

AU - Newman, William G

AU - Noh, Dong-Young

AU - Nordestgaard, Børge Grønne

AU - Obi, Nadia

AU - Olshan, Andrew F

AU - Olsson, Håkan

AU - Park-Simon, Tjoung-Won

AU - Petridis, Christos

AU - Pharoah, Paul D P

AU - Plaseska-Karanfilska, Dijana

AU - Presneau, Nadege

AU - Rashid, Muhammad U

AU - Rennert, Gad

AU - Rennert, Hedy S

AU - Rhenius, Valerie

AU - Romero, Atocha

AU - Saloustros, Emmanouil

AU - Sawyer, Elinor J

AU - Schneeweiss, Andreas

AU - Schwentner, Lukas

AU - Scott, Christopher G

AU - Shah, Mitul

AU - Shen, Chen-Yang

AU - Shu, Xiao-Ou

AU - Southey, Melissa C

AU - Stram, Daniel O

AU - Tamimi, Rulla M

AU - Tapper, William

AU - Tollenaar, Robert A E M

AU - Tomlinson, Ian

AU - Torres, Diana

AU - Troester, Melissa A

AU - Truong, Therese

AU - Vachon, Celine M

AU - Wang, Qin

AU - Wang, Sophia S

AU - Williams, Justin A

AU - Winqvist, Robert

AU - Wolk, Alicja

AU - Wu, Anna H

AU - Yoo, Keun-Young

AU - Yu, Jyh-Cherng

AU - Zheng, Wei

AU - Ziogas, Argyrios

AU - Yang, Xiaohong R

AU - Eliassen, A Heather

AU - Holmes, Michelle D

AU - Garcia-Closas, Montserrat

AU - Teo, Soo Hwang

AU - Schmidt, Marjanka K

AU - Chang-Claude, Jenny

N1 - Copyright ©2021, American Association for Cancer Research.

PY - 2021/4

Y1 - 2021/4

N2 - BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype.METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype.RESULTS: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5-25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06-1.34)]; current versus never smoking [1.37 (1.27-1.47)], high versus low physical activity [0.43 (0.21-0.86)], age ≥30 years versus <20 years at first pregnancy [0.79 (0.72-0.86)]; >0-<5 years versus ≥10 years since last full-term birth [1.31 (1.11-1.55)]; ever versus never use of oral contraceptives [0.91 (0.87-0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen-progestin therapy [0.61 (0.54-0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02-1.21) for current versus never smoking.CONCLUSIONS: We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype.IMPACT: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care.

AB - BACKGROUND: It is not known whether modifiable lifestyle factors that predict survival after invasive breast cancer differ by subtype.METHODS: We analyzed data for 121,435 women diagnosed with breast cancer from 67 studies in the Breast Cancer Association Consortium with 16,890 deaths (8,554 breast cancer specific) over 10 years. Cox regression was used to estimate associations between risk factors and 10-year all-cause mortality and breast cancer-specific mortality overall, by estrogen receptor (ER) status, and by intrinsic-like subtype.RESULTS: There was no evidence of heterogeneous associations between risk factors and mortality by subtype (Padj > 0.30). The strongest associations were between all-cause mortality and BMI ≥30 versus 18.5-25 kg/m2 [HR (95% confidence interval (CI), 1.19 (1.06-1.34)]; current versus never smoking [1.37 (1.27-1.47)], high versus low physical activity [0.43 (0.21-0.86)], age ≥30 years versus <20 years at first pregnancy [0.79 (0.72-0.86)]; >0-<5 years versus ≥10 years since last full-term birth [1.31 (1.11-1.55)]; ever versus never use of oral contraceptives [0.91 (0.87-0.96)]; ever versus never use of menopausal hormone therapy, including current estrogen-progestin therapy [0.61 (0.54-0.69)]. Similar associations with breast cancer mortality were weaker; for example, 1.11 (1.02-1.21) for current versus never smoking.CONCLUSIONS: We confirm associations between modifiable lifestyle factors and 10-year all-cause mortality. There was no strong evidence that associations differed by ER status or intrinsic-like subtype.IMPACT: Given the large dataset and lack of evidence that associations between modifiable risk factors and 10-year mortality differed by subtype, these associations could be cautiously used in prognostication models to inform patient-centered care.

U2 - 10.1158/1055-9965.EPI-20-0924

DO - 10.1158/1055-9965.EPI-20-0924

M3 - SCORING: Journal article

C2 - 33500318

VL - 30

SP - 623

EP - 642

JO - CANCER EPIDEM BIOMAR

JF - CANCER EPIDEM BIOMAR

SN - 1055-9965

IS - 4

ER -