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Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

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Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. / Brill, Monika S; Kleele, Tatjana; Ruschkies, Laura; Wang, Mengzhe; Marahori, Natalia A; Reuter, Miriam S; Hausrat, Torben J; Weigand, Emily; Fisher, Matthew; Ahles, Andrea; Engelhardt, Stefan; Bishop, Derron L; Kneussel, Matthias; Misgeld, Thomas.

In: NEURON, Vol. 92, No. 4, 23.11.2016, p. 845-856.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Brill, MS, Kleele, T, Ruschkies, L, Wang, M, Marahori, NA, Reuter, MS, Hausrat, TJ, Weigand, E, Fisher, M, Ahles, A, Engelhardt, S, Bishop, DL, Kneussel, M & Misgeld, T 2016, 'Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination', NEURON, vol. 92, no. 4, pp. 845-856. https://doi.org/10.1016/j.neuron.2016.09.049

APA

Brill, M. S., Kleele, T., Ruschkies, L., Wang, M., Marahori, N. A., Reuter, M. S., Hausrat, T. J., Weigand, E., Fisher, M., Ahles, A., Engelhardt, S., Bishop, D. L., Kneussel, M., & Misgeld, T. (2016). Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. NEURON, 92(4), 845-856. https://doi.org/10.1016/j.neuron.2016.09.049

Vancouver

Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS et al. Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination. NEURON. 2016 Nov 23;92(4):845-856. https://doi.org/10.1016/j.neuron.2016.09.049

Bibtex

@article{926d6362ba3445fc88b2dd39d8bea5a0,
title = "Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination",
abstract = "Developmental axon remodeling is characterized by the selective removal of branches from axon arbors. The mechanisms that underlie such branch loss are largely unknown. Additionally, how neuronal resources are specifically assigned to the branches of remodeling arbors is not understood. Here we show that axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, which results in local disassembly of the microtubule cytoskeleton and loss of axonal transport in branches that will subsequently dismantle. Accordingly, pharmacological microtubule stabilization delays neuromuscular synapse elimination. This branch-specific disassembly of the cytoskeleton appears to be mediated by the microtubule-severing enzyme spastin, which is dysfunctional in some forms of upper motor neuron disease. Our results demonstrate a physiological role for a neurodegeneration-associated modulator of the cytoskeleton, reveal unexpected cell biology of branch-specific axon plasticity and underscore the mechanistic similarities of axon loss in development and disease.",
author = "Brill, {Monika S} and Tatjana Kleele and Laura Ruschkies and Mengzhe Wang and Marahori, {Natalia A} and Reuter, {Miriam S} and Hausrat, {Torben J} and Emily Weigand and Matthew Fisher and Andrea Ahles and Stefan Engelhardt and Bishop, {Derron L} and Matthias Kneussel and Thomas Misgeld",
note = "Copyright {\textcopyright} 2016 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2016",
month = nov,
day = "23",
doi = "10.1016/j.neuron.2016.09.049",
language = "English",
volume = "92",
pages = "845--856",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

AU - Brill, Monika S

AU - Kleele, Tatjana

AU - Ruschkies, Laura

AU - Wang, Mengzhe

AU - Marahori, Natalia A

AU - Reuter, Miriam S

AU - Hausrat, Torben J

AU - Weigand, Emily

AU - Fisher, Matthew

AU - Ahles, Andrea

AU - Engelhardt, Stefan

AU - Bishop, Derron L

AU - Kneussel, Matthias

AU - Misgeld, Thomas

N1 - Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2016/11/23

Y1 - 2016/11/23

N2 - Developmental axon remodeling is characterized by the selective removal of branches from axon arbors. The mechanisms that underlie such branch loss are largely unknown. Additionally, how neuronal resources are specifically assigned to the branches of remodeling arbors is not understood. Here we show that axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, which results in local disassembly of the microtubule cytoskeleton and loss of axonal transport in branches that will subsequently dismantle. Accordingly, pharmacological microtubule stabilization delays neuromuscular synapse elimination. This branch-specific disassembly of the cytoskeleton appears to be mediated by the microtubule-severing enzyme spastin, which is dysfunctional in some forms of upper motor neuron disease. Our results demonstrate a physiological role for a neurodegeneration-associated modulator of the cytoskeleton, reveal unexpected cell biology of branch-specific axon plasticity and underscore the mechanistic similarities of axon loss in development and disease.

AB - Developmental axon remodeling is characterized by the selective removal of branches from axon arbors. The mechanisms that underlie such branch loss are largely unknown. Additionally, how neuronal resources are specifically assigned to the branches of remodeling arbors is not understood. Here we show that axon branch loss at the developing mouse neuromuscular junction is mediated by branch-specific microtubule severing, which results in local disassembly of the microtubule cytoskeleton and loss of axonal transport in branches that will subsequently dismantle. Accordingly, pharmacological microtubule stabilization delays neuromuscular synapse elimination. This branch-specific disassembly of the cytoskeleton appears to be mediated by the microtubule-severing enzyme spastin, which is dysfunctional in some forms of upper motor neuron disease. Our results demonstrate a physiological role for a neurodegeneration-associated modulator of the cytoskeleton, reveal unexpected cell biology of branch-specific axon plasticity and underscore the mechanistic similarities of axon loss in development and disease.

U2 - 10.1016/j.neuron.2016.09.049

DO - 10.1016/j.neuron.2016.09.049

M3 - SCORING: Journal article

C2 - 27773584

VL - 92

SP - 845

EP - 856

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 4

ER -