Brainstem fMRI signaling of surprise across different types of deviant stimuli

Audrey Mazancieux; Franck Mauconduit; Alexis Amadon; Jan Willem de Gee; Tobias H Donner; Florent Meyniel

doi:10.1016/j.celrep.2023.113405

Brainstem fMRI signaling of surprise across different types of deviant stimuli

Standard

Brainstem fMRI signaling of surprise across different types of deviant stimuli. / Mazancieux, Audrey; Mauconduit, Franck; Amadon, Alexis; Willem de Gee, Jan; Donner, Tobias H; Meyniel, Florent.

In: CELL REP, Vol. 42, No. 11, 28.11.2023, p. 113405.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mazancieux, A, Mauconduit, F, Amadon, A, Willem de Gee, J, Donner, TH & Meyniel, F 2023, 'Brainstem fMRI signaling of surprise across different types of deviant stimuli', CELL REP, vol. 42, no. 11, pp. 113405. https://doi.org/10.1016/j.celrep.2023.113405

APA

Mazancieux, A., Mauconduit, F., Amadon, A., Willem de Gee, J., Donner, T. H., & Meyniel, F. (2023). Brainstem fMRI signaling of surprise across different types of deviant stimuli. CELL REP, 42(11), 113405. https://doi.org/10.1016/j.celrep.2023.113405

Vancouver

Mazancieux A, Mauconduit F, Amadon A, Willem de Gee J, Donner TH, Meyniel F. Brainstem fMRI signaling of surprise across different types of deviant stimuli. CELL REP. 2023 Nov 28;42(11):113405. https://doi.org/10.1016/j.celrep.2023.113405

Bibtex

@article{1bdbde3f5c6c4be19611235a2820038c,

title = "Brainstem fMRI signaling of surprise across different types of deviant stimuli",

abstract = "Detection of deviant stimuli is crucial to orient and adapt our behavior. Previous work shows that deviant stimuli elicit phasic activation of the locus coeruleus (LC), which releases noradrenaline and controls central arousal. However, it is unclear whether the detection of behaviorally relevant deviant stimuli selectively triggers LC responses or other neuromodulatory systems (dopamine, serotonin, and acetylcholine). We combine human functional MRI (fMRI) recordings optimized for brainstem imaging with pupillometry to perform a mapping of deviant-related responses in subcortical structures. Participants have to detect deviant items in a {"}local-global{"} paradigm that distinguishes between deviance based on the stimulus probability and the sequence structure. fMRI responses to deviant stimuli are distributed in many cortical areas. Both types of deviance elicit responses in the pupil, LC, and other neuromodulatory systems. Our results reveal that the detection of task-relevant deviant items recruits the same multiple subcortical systems across computationally different types of deviance.",

keywords = "Humans, Magnetic Resonance Imaging/methods, Brain Stem, Locus Coeruleus/diagnostic imaging, Arousal, Pupil/physiology",

author = "Audrey Mazancieux and Franck Mauconduit and Alexis Amadon and {Willem de Gee}, Jan and Donner, {Tobias H} and Florent Meyniel",

year = "2023",

month = nov,

day = "28",

doi = "10.1016/j.celrep.2023.113405",

language = "English",

volume = "42",

pages = "113405",

journal = "CELL REP",

issn = "2211-1247",

publisher = "Elsevier",

number = "11",

}

RIS

TY - JOUR

T1 - Brainstem fMRI signaling of surprise across different types of deviant stimuli

AU - Mazancieux, Audrey

AU - Mauconduit, Franck

AU - Amadon, Alexis

AU - Willem de Gee, Jan

AU - Donner, Tobias H

AU - Meyniel, Florent

PY - 2023/11/28

Y1 - 2023/11/28

N2 - Detection of deviant stimuli is crucial to orient and adapt our behavior. Previous work shows that deviant stimuli elicit phasic activation of the locus coeruleus (LC), which releases noradrenaline and controls central arousal. However, it is unclear whether the detection of behaviorally relevant deviant stimuli selectively triggers LC responses or other neuromodulatory systems (dopamine, serotonin, and acetylcholine). We combine human functional MRI (fMRI) recordings optimized for brainstem imaging with pupillometry to perform a mapping of deviant-related responses in subcortical structures. Participants have to detect deviant items in a "local-global" paradigm that distinguishes between deviance based on the stimulus probability and the sequence structure. fMRI responses to deviant stimuli are distributed in many cortical areas. Both types of deviance elicit responses in the pupil, LC, and other neuromodulatory systems. Our results reveal that the detection of task-relevant deviant items recruits the same multiple subcortical systems across computationally different types of deviance.

AB - Detection of deviant stimuli is crucial to orient and adapt our behavior. Previous work shows that deviant stimuli elicit phasic activation of the locus coeruleus (LC), which releases noradrenaline and controls central arousal. However, it is unclear whether the detection of behaviorally relevant deviant stimuli selectively triggers LC responses or other neuromodulatory systems (dopamine, serotonin, and acetylcholine). We combine human functional MRI (fMRI) recordings optimized for brainstem imaging with pupillometry to perform a mapping of deviant-related responses in subcortical structures. Participants have to detect deviant items in a "local-global" paradigm that distinguishes between deviance based on the stimulus probability and the sequence structure. fMRI responses to deviant stimuli are distributed in many cortical areas. Both types of deviance elicit responses in the pupil, LC, and other neuromodulatory systems. Our results reveal that the detection of task-relevant deviant items recruits the same multiple subcortical systems across computationally different types of deviance.

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Brain Stem

KW - Locus Coeruleus/diagnostic imaging

KW - Arousal

KW - Pupil/physiology

U2 - 10.1016/j.celrep.2023.113405

DO - 10.1016/j.celrep.2023.113405

M3 - SCORING: Journal article

C2 - 37950868

VL - 42

SP - 113405

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 11

ER -