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Brain substrates of reward processing and the μ-opioid receptor a pathway into pain?

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Brain substrates of reward processing and the μ-opioid receptor a pathway into pain? / Nees, Frauke; Becker, Susanne; Millenet, Sabina; Banaschewski, Tobias; Poustka, Luise; Bokde, Arun; Bromberg, Uli; Büchel, Christian; Conrod, Patricia J; Desrivières, Sylvane; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Papadopoulos Orfanos, Dimitri; Paus, Tomáš; Smolka, Michael N; Walter, Henrik; Whelan, Rob; Schumann, Gunter; Flor, Herta; IMAGEN Consortium.

In: PAIN, Vol. 158, No. 2, 02.2017, p. 212-219.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Nees, F, Becker, S, Millenet, S, Banaschewski, T, Poustka, L, Bokde, A, Bromberg, U, Büchel, C, Conrod, PJ, Desrivières, S, Frouin, V, Gallinat, J, Garavan, H, Heinz, A, Ittermann, B, Martinot, J-L, Papadopoulos Orfanos, D, Paus, T, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Flor, H & IMAGEN Consortium 2017, 'Brain substrates of reward processing and the μ-opioid receptor a pathway into pain?', PAIN, vol. 158, no. 2, pp. 212-219. https://doi.org/10.1097/j.pain.0000000000000720

APA

Nees, F., Becker, S., Millenet, S., Banaschewski, T., Poustka, L., Bokde, A., Bromberg, U., Büchel, C., Conrod, P. J., Desrivières, S., Frouin, V., Gallinat, J., Garavan, H., Heinz, A., Ittermann, B., Martinot, J-L., Papadopoulos Orfanos, D., Paus, T., Smolka, M. N., ... IMAGEN Consortium (2017). Brain substrates of reward processing and the μ-opioid receptor a pathway into pain? PAIN, 158(2), 212-219. https://doi.org/10.1097/j.pain.0000000000000720

Vancouver

Nees F, Becker S, Millenet S, Banaschewski T, Poustka L, Bokde A et al. Brain substrates of reward processing and the μ-opioid receptor a pathway into pain? PAIN. 2017 Feb;158(2):212-219. https://doi.org/10.1097/j.pain.0000000000000720

Bibtex

@article{e1f5732a35704979a6898d87ddd5f35c,
title = "Brain substrates of reward processing and the μ-opioid receptor a pathway into pain?",
abstract = "The processing of reward and reinforcement learning seems to be important determinants of pain chronicity. However, reward processing is already altered early in life and if this is related to the development of pain symptoms later on is not known. The aim of this study was first to examine whether behavioural and brain-related indicators of reward processing at the age of 14 to 15 years are significant predictors of pain complaints 2 years later, at 16 to 17 years. Second, we investigated the contribution of genetic variations in the opioidergic system, which is linked to the processing of both, reward and pain, to this prediction. We used the monetary incentive delay task to assess reward processing, the Children's Somatization Inventory as measure of pain complaints and tested the effects of 2 single nucleotide polymorphisms (rs1799971/rs563649) of the human μ-opioid receptor gene. We found a significant prediction of pain complaints by responses in the dorsal striatum during reward feedback, independent of genetic predisposition. The relationship of pain complaints and activation in the periaqueductal gray and ventral striatum depended on the T-allele of rs563649. Carriers of this allele also showed more pain complaints than CC-allele carriers. Therefore, brain responses to reward outcomes and higher sensitivity to pain might be related already early in life and may thus set the course for pain complaints later in life, partly depending on a specific opioidergic genetic predisposition.",
author = "Frauke Nees and Susanne Becker and Sabina Millenet and Tobias Banaschewski and Luise Poustka and Arun Bokde and Uli Bromberg and Christian B{\"u}chel and Conrod, {Patricia J} and Sylvane Desrivi{\`e}res and Vincent Frouin and J{\"u}rgen Gallinat and Hugh Garavan and Andreas Heinz and Bernd Ittermann and Jean-Luc Martinot and {Papadopoulos Orfanos}, Dimitri and Tom{\'a}{\v s} Paus and Smolka, {Michael N} and Henrik Walter and Rob Whelan and Gunter Schumann and Herta Flor and {IMAGEN Consortium}",
year = "2017",
month = feb,
doi = "10.1097/j.pain.0000000000000720",
language = "English",
volume = "158",
pages = "212--219",
journal = "PAIN",
issn = "0304-3959",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Brain substrates of reward processing and the μ-opioid receptor a pathway into pain?

AU - Nees, Frauke

AU - Becker, Susanne

AU - Millenet, Sabina

AU - Banaschewski, Tobias

AU - Poustka, Luise

AU - Bokde, Arun

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Conrod, Patricia J

AU - Desrivières, Sylvane

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean-Luc

AU - Papadopoulos Orfanos, Dimitri

AU - Paus, Tomáš

AU - Smolka, Michael N

AU - Walter, Henrik

AU - Whelan, Rob

AU - Schumann, Gunter

AU - Flor, Herta

AU - IMAGEN Consortium

PY - 2017/2

Y1 - 2017/2

N2 - The processing of reward and reinforcement learning seems to be important determinants of pain chronicity. However, reward processing is already altered early in life and if this is related to the development of pain symptoms later on is not known. The aim of this study was first to examine whether behavioural and brain-related indicators of reward processing at the age of 14 to 15 years are significant predictors of pain complaints 2 years later, at 16 to 17 years. Second, we investigated the contribution of genetic variations in the opioidergic system, which is linked to the processing of both, reward and pain, to this prediction. We used the monetary incentive delay task to assess reward processing, the Children's Somatization Inventory as measure of pain complaints and tested the effects of 2 single nucleotide polymorphisms (rs1799971/rs563649) of the human μ-opioid receptor gene. We found a significant prediction of pain complaints by responses in the dorsal striatum during reward feedback, independent of genetic predisposition. The relationship of pain complaints and activation in the periaqueductal gray and ventral striatum depended on the T-allele of rs563649. Carriers of this allele also showed more pain complaints than CC-allele carriers. Therefore, brain responses to reward outcomes and higher sensitivity to pain might be related already early in life and may thus set the course for pain complaints later in life, partly depending on a specific opioidergic genetic predisposition.

AB - The processing of reward and reinforcement learning seems to be important determinants of pain chronicity. However, reward processing is already altered early in life and if this is related to the development of pain symptoms later on is not known. The aim of this study was first to examine whether behavioural and brain-related indicators of reward processing at the age of 14 to 15 years are significant predictors of pain complaints 2 years later, at 16 to 17 years. Second, we investigated the contribution of genetic variations in the opioidergic system, which is linked to the processing of both, reward and pain, to this prediction. We used the monetary incentive delay task to assess reward processing, the Children's Somatization Inventory as measure of pain complaints and tested the effects of 2 single nucleotide polymorphisms (rs1799971/rs563649) of the human μ-opioid receptor gene. We found a significant prediction of pain complaints by responses in the dorsal striatum during reward feedback, independent of genetic predisposition. The relationship of pain complaints and activation in the periaqueductal gray and ventral striatum depended on the T-allele of rs563649. Carriers of this allele also showed more pain complaints than CC-allele carriers. Therefore, brain responses to reward outcomes and higher sensitivity to pain might be related already early in life and may thus set the course for pain complaints later in life, partly depending on a specific opioidergic genetic predisposition.

U2 - 10.1097/j.pain.0000000000000720

DO - 10.1097/j.pain.0000000000000720

M3 - SCORING: Journal article

C2 - 28092323

VL - 158

SP - 212

EP - 219

JO - PAIN

JF - PAIN

SN - 0304-3959

IS - 2

ER -