Brain structural trajectories over the adult lifespan.
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Brain structural trajectories over the adult lifespan. / Ziegler, Gabriel; Dahnke, Robert; Jäncke, Lutz; Yotter, Rachel Aine; May, Arne; Gaser, Christian.
In: HUM BRAIN MAPP, Vol. 33, No. 10, 10, 2012, p. 2377-2389.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Brain structural trajectories over the adult lifespan.
AU - Ziegler, Gabriel
AU - Dahnke, Robert
AU - Jäncke, Lutz
AU - Yotter, Rachel Aine
AU - May, Arne
AU - Gaser, Christian
PY - 2012
Y1 - 2012
N2 - The aim of this large-sample cross-sectional voxel-based morphometry (VBM) study of anatomical brain data was to investigate linear and nonlinear age-related trajectories of grey matter volume in the human brain during the adult lifespan. To date, there are only a few structural brain studies investigating local nonlinear aspects at the voxel level, i.e., without using anatomical ROIs as a priori hypothesis. Therefore, we analyzed 547 T1-weighted MR images of healthy adult brains with an age range of 19 to 86 years, including 161 scans of subjects with ages 60 and older. We found that the gray matter volume in some regions did not linearly decrease over time, but rather exhibited a delayed decline. Nonlinear age trajectories were observed in the medial temporal lobe regions, the basal ganglia, and parts of the cerebellum. Their trajectories indicated a preservation of grey matter volume during the early adult lifespan. Interestingly, we found nonlinear grey matter structural dynamics specifically in parts of the brain that have been extensively discussed in the context of learning and memory. We propose a hypothesis in relation to the functional role of these brain regions that may explain these results.
AB - The aim of this large-sample cross-sectional voxel-based morphometry (VBM) study of anatomical brain data was to investigate linear and nonlinear age-related trajectories of grey matter volume in the human brain during the adult lifespan. To date, there are only a few structural brain studies investigating local nonlinear aspects at the voxel level, i.e., without using anatomical ROIs as a priori hypothesis. Therefore, we analyzed 547 T1-weighted MR images of healthy adult brains with an age range of 19 to 86 years, including 161 scans of subjects with ages 60 and older. We found that the gray matter volume in some regions did not linearly decrease over time, but rather exhibited a delayed decline. Nonlinear age trajectories were observed in the medial temporal lobe regions, the basal ganglia, and parts of the cerebellum. Their trajectories indicated a preservation of grey matter volume during the early adult lifespan. Interestingly, we found nonlinear grey matter structural dynamics specifically in parts of the brain that have been extensively discussed in the context of learning and memory. We propose a hypothesis in relation to the functional role of these brain regions that may explain these results.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Young Adult
KW - Magnetic Resonance Imaging
KW - Image Interpretation, Computer-Assisted
KW - Brain Mapping
KW - Aging
KW - Brain/anatomy & histology
KW - Nonlinear Dynamics
KW - Neural Pathways/anatomy & histology
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Young Adult
KW - Magnetic Resonance Imaging
KW - Image Interpretation, Computer-Assisted
KW - Brain Mapping
KW - Aging
KW - Brain/anatomy & histology
KW - Nonlinear Dynamics
KW - Neural Pathways/anatomy & histology
M3 - SCORING: Journal article
VL - 33
SP - 2377
EP - 2389
JO - HUM BRAIN MAPP
JF - HUM BRAIN MAPP
SN - 1065-9471
IS - 10
M1 - 10
ER -
