Research ExplorerPublicationsBrain Regions Related to Impulsivity Mediate the Effects of ...

Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior

Standard

Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior. / Mackey, Scott; Chaarani, Bader; Kan, Kees-Jan; Spechler, Philip A; Orr, Catherine; Banaschewski, Tobias; Barker, Gareth; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Paillère Martinot, Marie-Laure; Artiges, Eric; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Poustka, Luise; Smolka, Michael N; Jurk, Sarah; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Althoff, Robert R; Garavan, Hugh; IMAGEN Consortium.

In: BIOL PSYCHIAT, Vol. 82, No. 4, 15.08.2017, p. 275-282.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mackey, S, Chaarani, B, Kan, K-J, Spechler, PA, Orr, C, Banaschewski, T, Barker, G, Bokde, ALW, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Gowland, P, Heinz, A, Ittermann, B, Paillère Martinot, M-L, Artiges, E, Nees, F, Papadopoulos-Orfanos, D, Poustka, L, Smolka, MN, Jurk, S, Walter, H, Whelan, R, Schumann, G, Althoff, RR, Garavan, H & IMAGEN Consortium 2017, 'Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior', BIOL PSYCHIAT, vol. 82, no. 4, pp. 275-282. https://doi.org/10.1016/j.biopsych.2015.12.027

APA

Mackey, S., Chaarani, B., Kan, K-J., Spechler, P. A., Orr, C., Banaschewski, T., Barker, G., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Gowland, P., Heinz, A., Ittermann, B., ... IMAGEN Consortium (2017). Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior. BIOL PSYCHIAT, 82(4), 275-282. https://doi.org/10.1016/j.biopsych.2015.12.027

Vancouver

Mackey S, Chaarani B, Kan K-J, Spechler PA, Orr C, Banaschewski T et al. Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior. BIOL PSYCHIAT. 2017 Aug 15;82(4):275-282. https://doi.org/10.1016/j.biopsych.2015.12.027

Bibtex

@article{315b8b5d380e44788b216bf532ff8628,
title = "Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior",
abstract = "BACKGROUND: Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood.METHODS: Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n = 1830) of 14- to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use).RESULTS: Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior.CONCLUSIONS: Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior.",
author = "Scott Mackey and Bader Chaarani and Kees-Jan Kan and Spechler, {Philip A} and Catherine Orr and Tobias Banaschewski and Gareth Barker and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, {Patricia J} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Penny Gowland and Andreas Heinz and Bernd Ittermann and {Paill{\`e}re Martinot}, Marie-Laure and Eric Artiges and Frauke Nees and Dimitri Papadopoulos-Orfanos and Luise Poustka and Smolka, {Michael N} and Sarah Jurk and Henrik Walter and Robert Whelan and Gunter Schumann and Althoff, {Robert R} and Hugh Garavan and {IMAGEN Consortium}",
note = "Copyright {\textcopyright} 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = aug,
day = "15",
doi = "10.1016/j.biopsych.2015.12.027",
language = "English",
volume = "82",
pages = "275--282",
journal = "BIOL PSYCHIAT",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "4",

}

RIS

TY - JOUR

T1 - Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior

AU - Mackey, Scott

AU - Chaarani, Bader

AU - Kan, Kees-Jan

AU - Spechler, Philip A

AU - Orr, Catherine

AU - Banaschewski, Tobias

AU - Barker, Gareth

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Paillère Martinot, Marie-Laure

AU - Artiges, Eric

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Jurk, Sarah

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Althoff, Robert R

AU - Garavan, Hugh

AU - IMAGEN Consortium

N1 - Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2017/8/15

Y1 - 2017/8/15

N2 - BACKGROUND: Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood.METHODS: Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n = 1830) of 14- to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use).RESULTS: Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior.CONCLUSIONS: Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior.

AB - BACKGROUND: Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood.METHODS: Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n = 1830) of 14- to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use).RESULTS: Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior.CONCLUSIONS: Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior.

U2 - 10.1016/j.biopsych.2015.12.027

DO - 10.1016/j.biopsych.2015.12.027

M3 - SCORING: Journal article

C2 - 26971049

VL - 82

SP - 275

EP - 282

JO - BIOL PSYCHIAT

JF - BIOL PSYCHIAT

SN - 0006-3223

IS - 4

ER -