Neural development during human childhood and adolescence involves highly coordinated and sequenced events, characterized by both progressive and regressive processes. Despite a multitude of results demonstrating the age-dependent development of gray matter, white matter, and total brain volume, a reference curve allowing prediction of structural brain maturation is still lacking but would be clinically valuable. For the first time, the present study provides a validated reference curve for structural brain maturation during childhood and adolescence, based on structural MRI data.
