Brain magnetic resonance imaging in imported malaria
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Brain magnetic resonance imaging in imported malaria. / Frölich, Andreas M; Tober-Lau, Pinkus; Schönfeld, Michael; Brehm, Thomas T; Kurth, Florian; Vinnemeier, Christof D; Addo, Marylyn M; Fiehler, Jens; Rolling, Thierry.
In: MALARIA J, Vol. 18, No. 1, 12.03.2019, p. 74.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Brain magnetic resonance imaging in imported malaria
AU - Frölich, Andreas M
AU - Tober-Lau, Pinkus
AU - Schönfeld, Michael
AU - Brehm, Thomas T
AU - Kurth, Florian
AU - Vinnemeier, Christof D
AU - Addo, Marylyn M
AU - Fiehler, Jens
AU - Rolling, Thierry
PY - 2019/3/12
Y1 - 2019/3/12
N2 - BACKGROUND: Previous studies have documented a spectrum of brain magnetic resonance imaging (MRI) abnormalities in patients with cerebral malaria, but little is known about the prevalence of such abnormalities in patients with non-cerebral malaria. The aim of this study was to assess the frequency of brain MRI findings in returning travellers with non-cerebral malaria.METHODS: A total of 17 inpatients with microscopically confirmed Plasmodium falciparum non-cerebral malaria underwent structural brain MRI at 3.0 Tesla, including susceptibility-weighted imaging (SWI). Presence of imaging findings was recorded and correlated with clinical findings and parasitaemia.RESULTS: Structural brain abnormalities included a hyperintense lesion of the splenium on T2-weighted imaging (n = 3) accompanied by visible diffusion restriction (n = 2). Isolated brain microhaemorrhage was detected in 3 patients. T2-hyperintense signal abnormalities of the white matter ranged from absent to diffuse (n = 10 had 0-5 lesions, n = 5 had 5-20 lesions and 2 patients had more than 50 lesions). Imaging findings were not associated with parasitaemia or HRP2 levels.CONCLUSION: Brain MRI reveals a considerable frequency of T2-hyperintense splenial lesions in returning travellers with non-cerebral malaria, which appears to be independent of parasitaemia.
AB - BACKGROUND: Previous studies have documented a spectrum of brain magnetic resonance imaging (MRI) abnormalities in patients with cerebral malaria, but little is known about the prevalence of such abnormalities in patients with non-cerebral malaria. The aim of this study was to assess the frequency of brain MRI findings in returning travellers with non-cerebral malaria.METHODS: A total of 17 inpatients with microscopically confirmed Plasmodium falciparum non-cerebral malaria underwent structural brain MRI at 3.0 Tesla, including susceptibility-weighted imaging (SWI). Presence of imaging findings was recorded and correlated with clinical findings and parasitaemia.RESULTS: Structural brain abnormalities included a hyperintense lesion of the splenium on T2-weighted imaging (n = 3) accompanied by visible diffusion restriction (n = 2). Isolated brain microhaemorrhage was detected in 3 patients. T2-hyperintense signal abnormalities of the white matter ranged from absent to diffuse (n = 10 had 0-5 lesions, n = 5 had 5-20 lesions and 2 patients had more than 50 lesions). Imaging findings were not associated with parasitaemia or HRP2 levels.CONCLUSION: Brain MRI reveals a considerable frequency of T2-hyperintense splenial lesions in returning travellers with non-cerebral malaria, which appears to be independent of parasitaemia.
KW - Journal Article
U2 - 10.1186/s12936-019-2713-2
DO - 10.1186/s12936-019-2713-2
M3 - SCORING: Journal article
C2 - 30871543
VL - 18
SP - 74
JO - MALARIA J
JF - MALARIA J
SN - 1475-2875
IS - 1
ER -
