Brain insulin controls adipose tissue lipolysis and lipogenesis.
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Brain insulin controls adipose tissue lipolysis and lipogenesis. / Scherer, Thomas; O'Hare, James; Diggs-Andrews, Kelly; Schweiger, Martina; Cheng, Bob; Lindtner, Claudia; Zielinski, Elizabeth; Vempati, Prashant; Su, Kai; Dighe, Shveta; Milsom, Thomas; Puchowicz, Michelle; Scheja, Ludger; Zechner, Rudolf; Fisher, Simon J; Previs, Stephen F; Buettner, Christoph.
In: CELL METAB, Vol. 13, No. 2, 2, 2011, p. 183-194.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Brain insulin controls adipose tissue lipolysis and lipogenesis.
AU - Scherer, Thomas
AU - O'Hare, James
AU - Diggs-Andrews, Kelly
AU - Schweiger, Martina
AU - Cheng, Bob
AU - Lindtner, Claudia
AU - Zielinski, Elizabeth
AU - Vempati, Prashant
AU - Su, Kai
AU - Dighe, Shveta
AU - Milsom, Thomas
AU - Puchowicz, Michelle
AU - Scheja, Ludger
AU - Zechner, Rudolf
AU - Fisher, Simon J
AU - Previs, Stephen F
AU - Buettner, Christoph
PY - 2011
Y1 - 2011
N2 - White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.
AB - White adipose tissue (WAT) dysfunction plays a key role in the pathogenesis of type 2 diabetes (DM2). Unrestrained WAT lipolysis results in increased fatty acid release, leading to insulin resistance and lipotoxicity, while impaired de novo lipogenesis in WAT decreases the synthesis of insulin-sensitizing fatty acid species like palmitoleate. Here, we show that insulin infused into the mediobasal hypothalamus (MBH) of Sprague-Dawley rats increases WAT lipogenic protein expression, inactivates hormone-sensitive lipase (Hsl), and suppresses lipolysis. Conversely, mice that lack the neuronal insulin receptor exhibit unrestrained lipolysis and decreased de novo lipogenesis in WAT. Thus, brain and, in particular, hypothalamic insulin action play a pivotal role in WAT functionality.
KW - Animals
KW - Male
KW - Mice
KW - Rats
KW - Rats, Sprague-Dawley
KW - Signal Transduction
KW - Adipose Tissue, White/metabolism
KW - Brain/metabolism
KW - Glucose/metabolism
KW - Insulin/metabolism
KW - Lipogenesis
KW - Lipolysis
KW - Receptor, Insulin/metabolism
KW - Animals
KW - Male
KW - Mice
KW - Rats
KW - Rats, Sprague-Dawley
KW - Signal Transduction
KW - Adipose Tissue, White/metabolism
KW - Brain/metabolism
KW - Glucose/metabolism
KW - Insulin/metabolism
KW - Lipogenesis
KW - Lipolysis
KW - Receptor, Insulin/metabolism
M3 - SCORING: Journal article
VL - 13
SP - 183
EP - 194
JO - CELL METAB
JF - CELL METAB
SN - 1550-4131
IS - 2
M1 - 2
ER -