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Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.

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Botulinum toxin A does not alter capsaicin-induced pain perception in human skin. / Schulte-Mattler, Wilhelm J; Opatz, Oliver; Blersch, Wendelin; May, Arne; Bigalke, Hans; Wohlfahrt, Kai.

In: J NEUROL SCI, Vol. 260, No. 1-2, 1-2, 2007, p. 38-42.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schulte-Mattler, WJ, Opatz, O, Blersch, W, May, A, Bigalke, H & Wohlfahrt, K 2007, 'Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.', J NEUROL SCI, vol. 260, no. 1-2, 1-2, pp. 38-42. <http://www.ncbi.nlm.nih.gov/pubmed/17481662?dopt=Citation>

APA

Schulte-Mattler, W. J., Opatz, O., Blersch, W., May, A., Bigalke, H., & Wohlfahrt, K. (2007). Botulinum toxin A does not alter capsaicin-induced pain perception in human skin. J NEUROL SCI, 260(1-2), 38-42. [1-2]. http://www.ncbi.nlm.nih.gov/pubmed/17481662?dopt=Citation

Vancouver

Schulte-Mattler WJ, Opatz O, Blersch W, May A, Bigalke H, Wohlfahrt K. Botulinum toxin A does not alter capsaicin-induced pain perception in human skin. J NEUROL SCI. 2007;260(1-2):38-42. 1-2.

Bibtex

@article{dd29a4f9e4a04b579cb082f48c70762d,
title = "Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.",
abstract = "A genuine peripheral antinociceptive and anti-inflammatory effect of Botulinum neurotoxin type A (BoNT/A) has been proposed but could not be demonstrated in humans so far. Therefore, 100 mouse units of Botulinum toxin A (Dysport) and placebo were injected in a double blind paradigm in defined skin areas of 50 subjects. At baseline and after 4 and 8 weeks allodynia was induced in the skin areas with capsaicin ointment. Heat and cold pain threshold temperatures were measured with quantitative sensory testing, and threshold intensities upon electrical stimulation with a pain specific surface electrode were determined. No BoNT/A related differences in pain perception were found at any quality. There is neither a direct peripheral antinociceptive effect nor a significant effect against neurogenic inflammation of BoNT/A in humans.",
author = "Schulte-Mattler, {Wilhelm J} and Oliver Opatz and Wendelin Blersch and Arne May and Hans Bigalke and Kai Wohlfahrt",
year = "2007",
language = "Deutsch",
volume = "260",
pages = "38--42",
journal = "J NEUROL SCI",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Botulinum toxin A does not alter capsaicin-induced pain perception in human skin.

AU - Schulte-Mattler, Wilhelm J

AU - Opatz, Oliver

AU - Blersch, Wendelin

AU - May, Arne

AU - Bigalke, Hans

AU - Wohlfahrt, Kai

PY - 2007

Y1 - 2007

N2 - A genuine peripheral antinociceptive and anti-inflammatory effect of Botulinum neurotoxin type A (BoNT/A) has been proposed but could not be demonstrated in humans so far. Therefore, 100 mouse units of Botulinum toxin A (Dysport) and placebo were injected in a double blind paradigm in defined skin areas of 50 subjects. At baseline and after 4 and 8 weeks allodynia was induced in the skin areas with capsaicin ointment. Heat and cold pain threshold temperatures were measured with quantitative sensory testing, and threshold intensities upon electrical stimulation with a pain specific surface electrode were determined. No BoNT/A related differences in pain perception were found at any quality. There is neither a direct peripheral antinociceptive effect nor a significant effect against neurogenic inflammation of BoNT/A in humans.

AB - A genuine peripheral antinociceptive and anti-inflammatory effect of Botulinum neurotoxin type A (BoNT/A) has been proposed but could not be demonstrated in humans so far. Therefore, 100 mouse units of Botulinum toxin A (Dysport) and placebo were injected in a double blind paradigm in defined skin areas of 50 subjects. At baseline and after 4 and 8 weeks allodynia was induced in the skin areas with capsaicin ointment. Heat and cold pain threshold temperatures were measured with quantitative sensory testing, and threshold intensities upon electrical stimulation with a pain specific surface electrode were determined. No BoNT/A related differences in pain perception were found at any quality. There is neither a direct peripheral antinociceptive effect nor a significant effect against neurogenic inflammation of BoNT/A in humans.

M3 - SCORING: Zeitschriftenaufsatz

VL - 260

SP - 38

EP - 42

JO - J NEUROL SCI

JF - J NEUROL SCI

SN - 0022-510X

IS - 1-2

M1 - 1-2

ER -