Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder

Kristina Meyer; Catherine Hindi Attar; Jana Fiebig; Thomas Stamm; Tyler R Bassett; Michael Bauer; Udo Dannlowski; Thomas Ethofer; Irina Falkenberg; Andreas Jansen; Georg Juckel; Tilo Kircher; Christoph Mulert; Gregor Leicht; Anne Rau; Dirk Ritter; Philipp Ritter; Sarah Trost; Christoph Vogelbacher; Henrik Walter; Sarah Wolter; Martin Hautzinger; Felix Bermpohl

doi:10.1016/j.bpsc.2022.08.013

Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder

Standard

Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder. / Meyer, Kristina; Hindi Attar, Catherine; Fiebig, Jana; Stamm, Thomas; Bassett, Tyler R; Bauer, Michael; Dannlowski, Udo; Ethofer, Thomas; Falkenberg, Irina; Jansen, Andreas; Juckel, Georg; Kircher, Tilo; Mulert, Christoph; Leicht, Gregor; Rau, Anne; Ritter, Dirk; Ritter, Philipp; Trost, Sarah; Vogelbacher, Christoph; Walter, Henrik; Wolter, Sarah; Hautzinger, Martin; Bermpohl, Felix.

In: BIOL PSYCHIAT-COGN N, Vol. 8, No. 5, 05.2023, p. 572-580.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Meyer, K, Hindi Attar, C, Fiebig, J, Stamm, T, Bassett, TR, Bauer, M, Dannlowski, U, Ethofer, T, Falkenberg, I, Jansen, A, Juckel, G, Kircher, T, Mulert, C, Leicht, G, Rau, A, Ritter, D, Ritter, P, Trost, S, Vogelbacher, C, Walter, H, Wolter, S, Hautzinger, M & Bermpohl, F 2023, 'Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder', BIOL PSYCHIAT-COGN N, vol. 8, no. 5, pp. 572-580. https://doi.org/10.1016/j.bpsc.2022.08.013

APA

Meyer, K., Hindi Attar, C., Fiebig, J., Stamm, T., Bassett, T. R., Bauer, M., Dannlowski, U., Ethofer, T., Falkenberg, I., Jansen, A., Juckel, G., Kircher, T., Mulert, C., Leicht, G., Rau, A., Ritter, D., Ritter, P., Trost, S., Vogelbacher, C., ... Bermpohl, F. (2023). Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder. BIOL PSYCHIAT-COGN N, 8(5), 572-580. https://doi.org/10.1016/j.bpsc.2022.08.013

Vancouver

Meyer K, Hindi Attar C, Fiebig J, Stamm T, Bassett TR, Bauer M et al. Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder. BIOL PSYCHIAT-COGN N. 2023 May;8(5):572-580. https://doi.org/10.1016/j.bpsc.2022.08.013

Bibtex

@article{7355becb4c89492287afe3eb58fe432e,

title = "Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder",

abstract = "BACKGROUND: In bipolar disorder, impaired affective theory of mind (aToM) performance and aberrant neural activation in the ToM brain network partly explain social functioning impairments. However, it is not yet known whether psychotherapy of bipolar disorder influences neuroimaging markers of aToM.METHODS: In this study, conducted within the multicentric randomized controlled trial of the BipoLife consortium, patients with euthymic bipolar disorder underwent 2 group interventions over 6 months (mean = 28.45 weeks): 1) a specific, cognitive behavioral intervention (specific psychotherapeutic intervention [SEKT]) (n = 31) targeting impulse regulation, ToM, and social skills and 2) an emotion-focused intervention (FEST) (n = 28). To compare the effect of SEKT and FEST on neural correlates of aToM, patients performed an aToM task during functional magnetic resonance imaging before and after interventions (final functional magnetic resonance imaging sample of pre- and postcompleters, SEKT: n = 16; FEST: n = 17). Healthy control subjects (n = 32) were scanned twice with the same time interval. Because ToM was trained in SEKT, we expected an increased ToM network activation in SEKT relative to FEST postintervention.RESULTS: Both treatments effectively stabilized patients' euthymic state in terms of affective symptoms, life satisfaction, and global functioning. Confirming our expectations, SEKT patients showed increased neural activation within regions of the ToM network, bilateral temporoparietal junction, posterior cingulate cortex, and precuneus, whereas FEST patients did not.CONCLUSIONS: The stabilizing effect of SEKT on clinical outcomes went along with increased neural activation of the ToM network, while FEST possibly exerted its positive effect by other, yet unexplored routes.",

author = "Kristina Meyer and {Hindi Attar}, Catherine and Jana Fiebig and Thomas Stamm and Bassett, {Tyler R} and Michael Bauer and Udo Dannlowski and Thomas Ethofer and Irina Falkenberg and Andreas Jansen and Georg Juckel and Tilo Kircher and Christoph Mulert and Gregor Leicht and Anne Rau and Dirk Ritter and Philipp Ritter and Sarah Trost and Christoph Vogelbacher and Henrik Walter and Sarah Wolter and Martin Hautzinger and Felix Bermpohl",

year = "2023",

month = may,

doi = "10.1016/j.bpsc.2022.08.013",

language = "English",

volume = "8",

pages = "572--580",

journal = "BIOL PSYCHIAT-COGN N",

issn = "2451-9022",

publisher = "Elsevier Inc.",

number = "5",

}

RIS

TY - JOUR

T1 - Boosting the Theory of Mind Network: Specific Psychotherapy Increases Neural Correlates of Affective Theory of Mind in Euthymic Bipolar Disorder

AU - Meyer, Kristina

AU - Hindi Attar, Catherine

AU - Fiebig, Jana

AU - Stamm, Thomas

AU - Bassett, Tyler R

AU - Bauer, Michael

AU - Dannlowski, Udo

AU - Ethofer, Thomas

AU - Falkenberg, Irina

AU - Jansen, Andreas

AU - Juckel, Georg

AU - Kircher, Tilo

AU - Mulert, Christoph

AU - Leicht, Gregor

AU - Rau, Anne

AU - Ritter, Dirk

AU - Ritter, Philipp

AU - Trost, Sarah

AU - Vogelbacher, Christoph

AU - Walter, Henrik

AU - Wolter, Sarah

AU - Hautzinger, Martin

AU - Bermpohl, Felix

PY - 2023/5

Y1 - 2023/5

N2 - BACKGROUND: In bipolar disorder, impaired affective theory of mind (aToM) performance and aberrant neural activation in the ToM brain network partly explain social functioning impairments. However, it is not yet known whether psychotherapy of bipolar disorder influences neuroimaging markers of aToM.METHODS: In this study, conducted within the multicentric randomized controlled trial of the BipoLife consortium, patients with euthymic bipolar disorder underwent 2 group interventions over 6 months (mean = 28.45 weeks): 1) a specific, cognitive behavioral intervention (specific psychotherapeutic intervention [SEKT]) (n = 31) targeting impulse regulation, ToM, and social skills and 2) an emotion-focused intervention (FEST) (n = 28). To compare the effect of SEKT and FEST on neural correlates of aToM, patients performed an aToM task during functional magnetic resonance imaging before and after interventions (final functional magnetic resonance imaging sample of pre- and postcompleters, SEKT: n = 16; FEST: n = 17). Healthy control subjects (n = 32) were scanned twice with the same time interval. Because ToM was trained in SEKT, we expected an increased ToM network activation in SEKT relative to FEST postintervention.RESULTS: Both treatments effectively stabilized patients' euthymic state in terms of affective symptoms, life satisfaction, and global functioning. Confirming our expectations, SEKT patients showed increased neural activation within regions of the ToM network, bilateral temporoparietal junction, posterior cingulate cortex, and precuneus, whereas FEST patients did not.CONCLUSIONS: The stabilizing effect of SEKT on clinical outcomes went along with increased neural activation of the ToM network, while FEST possibly exerted its positive effect by other, yet unexplored routes.

AB - BACKGROUND: In bipolar disorder, impaired affective theory of mind (aToM) performance and aberrant neural activation in the ToM brain network partly explain social functioning impairments. However, it is not yet known whether psychotherapy of bipolar disorder influences neuroimaging markers of aToM.METHODS: In this study, conducted within the multicentric randomized controlled trial of the BipoLife consortium, patients with euthymic bipolar disorder underwent 2 group interventions over 6 months (mean = 28.45 weeks): 1) a specific, cognitive behavioral intervention (specific psychotherapeutic intervention [SEKT]) (n = 31) targeting impulse regulation, ToM, and social skills and 2) an emotion-focused intervention (FEST) (n = 28). To compare the effect of SEKT and FEST on neural correlates of aToM, patients performed an aToM task during functional magnetic resonance imaging before and after interventions (final functional magnetic resonance imaging sample of pre- and postcompleters, SEKT: n = 16; FEST: n = 17). Healthy control subjects (n = 32) were scanned twice with the same time interval. Because ToM was trained in SEKT, we expected an increased ToM network activation in SEKT relative to FEST postintervention.RESULTS: Both treatments effectively stabilized patients' euthymic state in terms of affective symptoms, life satisfaction, and global functioning. Confirming our expectations, SEKT patients showed increased neural activation within regions of the ToM network, bilateral temporoparietal junction, posterior cingulate cortex, and precuneus, whereas FEST patients did not.CONCLUSIONS: The stabilizing effect of SEKT on clinical outcomes went along with increased neural activation of the ToM network, while FEST possibly exerted its positive effect by other, yet unexplored routes.

U2 - 10.1016/j.bpsc.2022.08.013

DO - 10.1016/j.bpsc.2022.08.013

M3 - SCORING: Journal article

C2 - 36087699

VL - 8

SP - 572

EP - 580

JO - BIOL PSYCHIAT-COGN N

JF - BIOL PSYCHIAT-COGN N

SN - 2451-9022

IS - 5

ER -