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Bone fragility in diabetes: novel concepts and clinical implications

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Bone fragility in diabetes: novel concepts and clinical implications. / Hofbauer, Lorenz C; Busse, Björn; Eastell, Richard; Ferrari, Serge; Frost, Morten; Müller, Ralph; Burden, Andrea M; Rivadeneira, Fernando; Napoli, Nicola; Rauner, Martina.

In: LANCET DIABETES ENDO, Vol. 10, No. 3, 03.2022, p. 207-220.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Hofbauer, LC, Busse, B, Eastell, R, Ferrari, S, Frost, M, Müller, R, Burden, AM, Rivadeneira, F, Napoli, N & Rauner, M 2022, 'Bone fragility in diabetes: novel concepts and clinical implications', LANCET DIABETES ENDO, vol. 10, no. 3, pp. 207-220. https://doi.org/10.1016/S2213-8587(21)00347-8

APA

Hofbauer, L. C., Busse, B., Eastell, R., Ferrari, S., Frost, M., Müller, R., Burden, A. M., Rivadeneira, F., Napoli, N., & Rauner, M. (2022). Bone fragility in diabetes: novel concepts and clinical implications. LANCET DIABETES ENDO, 10(3), 207-220. https://doi.org/10.1016/S2213-8587(21)00347-8

Vancouver

Hofbauer LC, Busse B, Eastell R, Ferrari S, Frost M, Müller R et al. Bone fragility in diabetes: novel concepts and clinical implications. LANCET DIABETES ENDO. 2022 Mar;10(3):207-220. https://doi.org/10.1016/S2213-8587(21)00347-8

Bibtex

@article{2ed946646bb14836ad64b6f933beb0a3,
title = "Bone fragility in diabetes: novel concepts and clinical implications",
abstract = "Increased fracture risk represents an emerging and severe complication of diabetes. The resulting prolonged immobility and hospitalisations can lead to substantial morbidity and mortality. In type 1 diabetes, bone mass and bone strength are reduced, resulting in up to a five-times greater risk of fractures throughout life. In type 2 diabetes, fracture risk is increased despite a normal bone mass. Conventional dual-energy x-ray absorptiometry might underestimate fracture risk, but can be improved by applying specific adjustments. Bone fragility in diabetes can result from cellular abnormalities, matrix interactions, immune and vascular changes, and musculoskeletal maladaptation to chronic hyperglycaemia. This Review summarises how the bone microenvironment responds to type 1 and type 2 diabetes, and the mechanisms underlying fragility fractures. We describe the value of novel imaging technologies and the clinical utility of biomarkers, and discuss current and future therapeutic approaches that protect bone health in people with diabetes.",
author = "Hofbauer, {Lorenz C} and Bj{\"o}rn Busse and Richard Eastell and Serge Ferrari and Morten Frost and Ralph M{\"u}ller and Burden, {Andrea M} and Fernando Rivadeneira and Nicola Napoli and Martina Rauner",
year = "2022",
month = mar,
doi = "10.1016/S2213-8587(21)00347-8",
language = "English",
volume = "10",
pages = "207--220",
journal = "LANCET DIABETES ENDO",
issn = "2213-8587",
publisher = "Elsevier BV",
number = "3",

}

RIS

TY - JOUR

T1 - Bone fragility in diabetes: novel concepts and clinical implications

AU - Hofbauer, Lorenz C

AU - Busse, Björn

AU - Eastell, Richard

AU - Ferrari, Serge

AU - Frost, Morten

AU - Müller, Ralph

AU - Burden, Andrea M

AU - Rivadeneira, Fernando

AU - Napoli, Nicola

AU - Rauner, Martina

PY - 2022/3

Y1 - 2022/3

N2 - Increased fracture risk represents an emerging and severe complication of diabetes. The resulting prolonged immobility and hospitalisations can lead to substantial morbidity and mortality. In type 1 diabetes, bone mass and bone strength are reduced, resulting in up to a five-times greater risk of fractures throughout life. In type 2 diabetes, fracture risk is increased despite a normal bone mass. Conventional dual-energy x-ray absorptiometry might underestimate fracture risk, but can be improved by applying specific adjustments. Bone fragility in diabetes can result from cellular abnormalities, matrix interactions, immune and vascular changes, and musculoskeletal maladaptation to chronic hyperglycaemia. This Review summarises how the bone microenvironment responds to type 1 and type 2 diabetes, and the mechanisms underlying fragility fractures. We describe the value of novel imaging technologies and the clinical utility of biomarkers, and discuss current and future therapeutic approaches that protect bone health in people with diabetes.

AB - Increased fracture risk represents an emerging and severe complication of diabetes. The resulting prolonged immobility and hospitalisations can lead to substantial morbidity and mortality. In type 1 diabetes, bone mass and bone strength are reduced, resulting in up to a five-times greater risk of fractures throughout life. In type 2 diabetes, fracture risk is increased despite a normal bone mass. Conventional dual-energy x-ray absorptiometry might underestimate fracture risk, but can be improved by applying specific adjustments. Bone fragility in diabetes can result from cellular abnormalities, matrix interactions, immune and vascular changes, and musculoskeletal maladaptation to chronic hyperglycaemia. This Review summarises how the bone microenvironment responds to type 1 and type 2 diabetes, and the mechanisms underlying fragility fractures. We describe the value of novel imaging technologies and the clinical utility of biomarkers, and discuss current and future therapeutic approaches that protect bone health in people with diabetes.

U2 - 10.1016/S2213-8587(21)00347-8

DO - 10.1016/S2213-8587(21)00347-8

M3 - SCORING: Review article

C2 - 35101185

VL - 10

SP - 207

EP - 220

JO - LANCET DIABETES ENDO

JF - LANCET DIABETES ENDO

SN - 2213-8587

IS - 3

ER -