BOLD responses to itch in the human spinal cord

Missanga F van de Sand; Christian Sprenger; Christian Büchel

doi:10.1016/j.neuroimage.2014.12.019

BOLD responses to itch in the human spinal cord

Standard

BOLD responses to itch in the human spinal cord. / van de Sand, Missanga F; Sprenger, Christian ; Büchel, Christian.

In: NEUROIMAGE, Vol. 108, 03.2015, p. 138-43.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

van de Sand, MF, Sprenger, C & Büchel, C 2015, 'BOLD responses to itch in the human spinal cord', NEUROIMAGE, vol. 108, pp. 138-43. https://doi.org/10.1016/j.neuroimage.2014.12.019

APA

van de Sand, M. F., Sprenger, C., & Büchel, C. (2015). BOLD responses to itch in the human spinal cord. NEUROIMAGE, 108, 138-43. https://doi.org/10.1016/j.neuroimage.2014.12.019

Vancouver

van de Sand MF, Sprenger C , Büchel C. BOLD responses to itch in the human spinal cord. NEUROIMAGE. 2015 Mar;108:138-43. https://doi.org/10.1016/j.neuroimage.2014.12.019

Bibtex

@article{bf0e1c79579246d3b5bfb47fdcc301dc,

title = "BOLD responses to itch in the human spinal cord",

abstract = "Itch is an independent sensory modality and a very common symptom with manifold causes. However, the neuronal representation of itch perception in the central nervous system is not entirely understood and there is hardly any knowledge about neuronal correlates of itch in the human spinal cord. In the present study we aimed to identify itch-related neural activity in the cervical spinal cord in healthy volunteers employing high-resolution functional magnetic resonance imaging (fMRI). We studied histamine-induced itch on the radial forearm and modulated itch intensity by non-noxious cooling. To control for effects of thermal stimulation (i.e., cooling), volunteers also underwent an identical session without histamine. We studied histamine-induced itch on the radial forearm, by using a block design with alternating blocks of non-noxious cooling separated by blocks of skin temperature. Non-noxious cooling of histamine-treated skin compared to cooling of non-treated skin led to a significant increase in itch perception. On the neural level, itch was paralleled by activation in the dorsal horn of the spinal cord at the transition between spinal segment C5 and C6, ipsilateral to the side of stimulation. These results suggest that itch-related neural activity can be assessed noninvasively in humans at the spinal cord.",

author = "{van de Sand}, {Missanga F} and Christian Sprenger and Christian B{\"u}chel",

year = "2015",

month = mar,

doi = "10.1016/j.neuroimage.2014.12.019",

language = "English",

volume = "108",

pages = "138--43",

journal = "NEUROIMAGE",

issn = "1053-8119",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - BOLD responses to itch in the human spinal cord

AU - van de Sand, Missanga F

AU - Sprenger, Christian

AU - Büchel, Christian

PY - 2015/3

Y1 - 2015/3

N2 - Itch is an independent sensory modality and a very common symptom with manifold causes. However, the neuronal representation of itch perception in the central nervous system is not entirely understood and there is hardly any knowledge about neuronal correlates of itch in the human spinal cord. In the present study we aimed to identify itch-related neural activity in the cervical spinal cord in healthy volunteers employing high-resolution functional magnetic resonance imaging (fMRI). We studied histamine-induced itch on the radial forearm and modulated itch intensity by non-noxious cooling. To control for effects of thermal stimulation (i.e., cooling), volunteers also underwent an identical session without histamine. We studied histamine-induced itch on the radial forearm, by using a block design with alternating blocks of non-noxious cooling separated by blocks of skin temperature. Non-noxious cooling of histamine-treated skin compared to cooling of non-treated skin led to a significant increase in itch perception. On the neural level, itch was paralleled by activation in the dorsal horn of the spinal cord at the transition between spinal segment C5 and C6, ipsilateral to the side of stimulation. These results suggest that itch-related neural activity can be assessed noninvasively in humans at the spinal cord.

AB - Itch is an independent sensory modality and a very common symptom with manifold causes. However, the neuronal representation of itch perception in the central nervous system is not entirely understood and there is hardly any knowledge about neuronal correlates of itch in the human spinal cord. In the present study we aimed to identify itch-related neural activity in the cervical spinal cord in healthy volunteers employing high-resolution functional magnetic resonance imaging (fMRI). We studied histamine-induced itch on the radial forearm and modulated itch intensity by non-noxious cooling. To control for effects of thermal stimulation (i.e., cooling), volunteers also underwent an identical session without histamine. We studied histamine-induced itch on the radial forearm, by using a block design with alternating blocks of non-noxious cooling separated by blocks of skin temperature. Non-noxious cooling of histamine-treated skin compared to cooling of non-treated skin led to a significant increase in itch perception. On the neural level, itch was paralleled by activation in the dorsal horn of the spinal cord at the transition between spinal segment C5 and C6, ipsilateral to the side of stimulation. These results suggest that itch-related neural activity can be assessed noninvasively in humans at the spinal cord.

U2 - 10.1016/j.neuroimage.2014.12.019

DO - 10.1016/j.neuroimage.2014.12.019

M3 - SCORING: Journal article

C2 - 25497685

VL - 108

SP - 138

EP - 143

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

ER -