BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia
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BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia. / Schoennagel, Bjoern P; Yamamura, Jin; Fischer, Roland; de Sousa, Manuela Tavares; Weyhmiller, Marcela; Birkelbach, Moritz; Kooijman, Hendrik; Adam, Gerhard; Wedegärtner, Ulrike.
In: J MAGN RESON IMAGING, 18.12.2013.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia
AU - Schoennagel, Bjoern P
AU - Yamamura, Jin
AU - Fischer, Roland
AU - de Sousa, Manuela Tavares
AU - Weyhmiller, Marcela
AU - Birkelbach, Moritz
AU - Kooijman, Hendrik
AU - Adam, Gerhard
AU - Wedegärtner, Ulrike
N1 - Copyright © 2013 Wiley Periodicals, Inc.
PY - 2013/12/18
Y1 - 2013/12/18
N2 - PURPOSE: To calculate regional fetal brain oxygen saturation (sO2 ) during hypoxia in sheep.MATERIALS AND METHODS: Eight pregnant ewes were examined at a 3T MR-scanner using blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) to measure signal intensity changes of the fetal brain during a control period and a period of induced hypoxia. Regions of interest were placed in the fetal cerebrum to assess ΔR2* from GRE signal intensity plateaus (Scontrol , Shypoxia ) and the relation between ΔR2* and ΔpO2 was analyzed. A probe was placed surgically in the fetal brain to directly measure local pO2 as a reference standard. Baseline and hypoxic pO2 values were recorded and compared (ΔpO2 ).RESULTS: Mean fetal brain pO2 decreased from 14.3 mmHg (95% confidence interval [CI]: 10-19) to 3.4 mmHg (95% CI: 2-5) during hypoxia (mean ΔpO2 = 10.9 mmHg and ΔR2* = -5s(-1) ). A significant correlation between ΔR2* and ΔpO2 was noted (r = 0.93, P < 0.001), and conversion of pO2 into sO2 resulted in a linear regression coefficient of (-0.14 ± 0.01)s(-1) /% (r(2) = 0.91).CONCLUSION: Measured fetal brain BOLD-MRI was compared and converted to pO2 , followed by calculation of cerebral sO2 .J. Magn. Reson. Imaging 2013. © 2013 Wiley Periodicals, Inc.
AB - PURPOSE: To calculate regional fetal brain oxygen saturation (sO2 ) during hypoxia in sheep.MATERIALS AND METHODS: Eight pregnant ewes were examined at a 3T MR-scanner using blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) to measure signal intensity changes of the fetal brain during a control period and a period of induced hypoxia. Regions of interest were placed in the fetal cerebrum to assess ΔR2* from GRE signal intensity plateaus (Scontrol , Shypoxia ) and the relation between ΔR2* and ΔpO2 was analyzed. A probe was placed surgically in the fetal brain to directly measure local pO2 as a reference standard. Baseline and hypoxic pO2 values were recorded and compared (ΔpO2 ).RESULTS: Mean fetal brain pO2 decreased from 14.3 mmHg (95% confidence interval [CI]: 10-19) to 3.4 mmHg (95% CI: 2-5) during hypoxia (mean ΔpO2 = 10.9 mmHg and ΔR2* = -5s(-1) ). A significant correlation between ΔR2* and ΔpO2 was noted (r = 0.93, P < 0.001), and conversion of pO2 into sO2 resulted in a linear regression coefficient of (-0.14 ± 0.01)s(-1) /% (r(2) = 0.91).CONCLUSION: Measured fetal brain BOLD-MRI was compared and converted to pO2 , followed by calculation of cerebral sO2 .J. Magn. Reson. Imaging 2013. © 2013 Wiley Periodicals, Inc.
U2 - 10.1002/jmri.24555
DO - 10.1002/jmri.24555
M3 - SCORING: Journal article
C2 - 24357078
JO - J MAGN RESON IMAGING
JF - J MAGN RESON IMAGING
SN - 1053-1807
ER -
