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Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

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Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. / Büchel, Christian; Peters, Jan; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Conrod, Patricia J; Flor, Herta; Papadopoulos, Dimitri; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Walter, Henrik; Ittermann, Bernd; Mann, Karl; Martinot, Jean-Luc; Paillère-Martinot, Marie-Laure; Nees, Frauke; Paus, Tomas; Pausova, Zdenka; Poustka, Luise; Rietschel, Marcella; Robbins, Trevor W; Smolka, Michael N; Gallinat, Juergen; Schumann, Gunter; Knutson, Brian; IMAGEN Consortium.

In: NAT COMMUN, Vol. 8, 21.02.2017, p. 14140.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Büchel, C, Peters, J, Banaschewski, T, Bokde, ALW, Bromberg, U, Conrod, PJ, Flor, H, Papadopoulos, D, Garavan, H, Gowland, P, Heinz, A, Walter, H, Ittermann, B, Mann, K, Martinot, J-L, Paillère-Martinot, M-L, Nees, F, Paus, T, Pausova, Z, Poustka, L, Rietschel, M, Robbins, TW, Smolka, MN, Gallinat, J, Schumann, G, Knutson, B & IMAGEN Consortium 2017, 'Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents', NAT COMMUN, vol. 8, pp. 14140. https://doi.org/10.1038/ncomms14140

APA

Büchel, C., Peters, J., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Conrod, P. J., Flor, H., Papadopoulos, D., Garavan, H., Gowland, P., Heinz, A., Walter, H., Ittermann, B., Mann, K., Martinot, J-L., Paillère-Martinot, M-L., Nees, F., Paus, T., Pausova, Z., ... IMAGEN Consortium (2017). Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. NAT COMMUN, 8, 14140. https://doi.org/10.1038/ncomms14140

Vancouver

Büchel C, Peters J, Banaschewski T, Bokde ALW, Bromberg U, Conrod PJ et al. Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. NAT COMMUN. 2017 Feb 21;8:14140. https://doi.org/10.1038/ncomms14140

Bibtex

@article{34e8e8dd88be4fd898f8c50ec64870d2,
title = "Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents",
abstract = "Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.",
keywords = "Journal Article",
author = "Christian B{\"u}chel and Jan Peters and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Conrod, {Patricia J} and Herta Flor and Dimitri Papadopoulos and Hugh Garavan and Penny Gowland and Andreas Heinz and Henrik Walter and Bernd Ittermann and Karl Mann and Jean-Luc Martinot and Marie-Laure Paill{\`e}re-Martinot and Frauke Nees and Tomas Paus and Zdenka Pausova and Luise Poustka and Marcella Rietschel and Robbins, {Trevor W} and Smolka, {Michael N} and Juergen Gallinat and Gunter Schumann and Brian Knutson and {IMAGEN Consortium}",
year = "2017",
month = feb,
day = "21",
doi = "10.1038/ncomms14140",
language = "English",
volume = "8",
pages = "14140",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents

AU - Büchel, Christian

AU - Peters, Jan

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Conrod, Patricia J

AU - Flor, Herta

AU - Papadopoulos, Dimitri

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Walter, Henrik

AU - Ittermann, Bernd

AU - Mann, Karl

AU - Martinot, Jean-Luc

AU - Paillère-Martinot, Marie-Laure

AU - Nees, Frauke

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Poustka, Luise

AU - Rietschel, Marcella

AU - Robbins, Trevor W

AU - Smolka, Michael N

AU - Gallinat, Juergen

AU - Schumann, Gunter

AU - Knutson, Brian

AU - IMAGEN Consortium

PY - 2017/2/21

Y1 - 2017/2/21

N2 - Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.

AB - Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.

KW - Journal Article

U2 - 10.1038/ncomms14140

DO - 10.1038/ncomms14140

M3 - SCORING: Journal article

C2 - 28221370

VL - 8

SP - 14140

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -