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Blood-brain barrier permeability to the neuroprotectant oxyresveratrol

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Blood-brain barrier permeability to the neuroprotectant oxyresveratrol. / Breuer, Christian; Wolf, Gerald; Andrabi, Shaida A; Lorenz, Peter; Horn, Thomas F W.

In: NEUROSCI LETT, Vol. 393, No. 2-3, 30.01.2006, p. 113-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Breuer, C, Wolf, G, Andrabi, SA, Lorenz, P & Horn, TFW 2006, 'Blood-brain barrier permeability to the neuroprotectant oxyresveratrol', NEUROSCI LETT, vol. 393, no. 2-3, pp. 113-8. https://doi.org/10.1016/j.neulet.2005.09.081

APA

Breuer, C., Wolf, G., Andrabi, S. A., Lorenz, P., & Horn, T. F. W. (2006). Blood-brain barrier permeability to the neuroprotectant oxyresveratrol. NEUROSCI LETT, 393(2-3), 113-8. https://doi.org/10.1016/j.neulet.2005.09.081

Vancouver

Breuer C, Wolf G, Andrabi SA, Lorenz P, Horn TFW. Blood-brain barrier permeability to the neuroprotectant oxyresveratrol. NEUROSCI LETT. 2006 Jan 30;393(2-3):113-8. https://doi.org/10.1016/j.neulet.2005.09.081

Bibtex

@article{f3dfd22b47fd4b79bfc824da7eabf6d4,
title = "Blood-brain barrier permeability to the neuroprotectant oxyresveratrol",
abstract = "We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.",
keywords = "Animals, Antigens, CD11b, Area Under Curve, Blood-Brain Barrier, Cerebral Infarction, Chromatography, High Pressure Liquid, Corpus Striatum, Fluorescein, Fluoresceins, Indoles, Infarction, Middle Cerebral Artery, Male, Microdialysis, Neuroprotective Agents, Organic Chemicals, Permeability, Rats, Reperfusion, Stilbenes, Time Factors, Tissue Distribution",
author = "Christian Breuer and Gerald Wolf and Andrabi, {Shaida A} and Peter Lorenz and Horn, {Thomas F W}",
year = "2006",
month = jan,
day = "30",
doi = "10.1016/j.neulet.2005.09.081",
language = "English",
volume = "393",
pages = "113--8",
journal = "NEUROSCI LETT",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

RIS

TY - JOUR

T1 - Blood-brain barrier permeability to the neuroprotectant oxyresveratrol

AU - Breuer, Christian

AU - Wolf, Gerald

AU - Andrabi, Shaida A

AU - Lorenz, Peter

AU - Horn, Thomas F W

PY - 2006/1/30

Y1 - 2006/1/30

N2 - We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.

AB - We investigated to what extent the antioxidative hydroxystilbene oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene, OXY), that we showed earlier to be strongly neuroprotective in a stroke model, may cross the blood-brain barrier (BBB) in healthy rats and in subjects submitted to focal infarction. Tissue extraction and in vivo microdialysis in the striatum show that systematically applied OXY is able to penetrate the BBB in control animals, but to a low extent. Microdialysis samples from animals that were subjected to a middle cerebral artery occlusion (MCAO) displayed strongly increased OXY levels (more than six-fold) in the infarct region as compared to sham-operated rats. Our data show that OXY may exert direct protective effects in the brain by crossing the BBB and may prove an excellent complementary drug for the treatment of neurodegenerative disorders that causally involve oxidative/nitrosative stress, especially in stroke.

KW - Animals

KW - Antigens, CD11b

KW - Area Under Curve

KW - Blood-Brain Barrier

KW - Cerebral Infarction

KW - Chromatography, High Pressure Liquid

KW - Corpus Striatum

KW - Fluorescein

KW - Fluoresceins

KW - Indoles

KW - Infarction, Middle Cerebral Artery

KW - Male

KW - Microdialysis

KW - Neuroprotective Agents

KW - Organic Chemicals

KW - Permeability

KW - Rats

KW - Reperfusion

KW - Stilbenes

KW - Time Factors

KW - Tissue Distribution

U2 - 10.1016/j.neulet.2005.09.081

DO - 10.1016/j.neulet.2005.09.081

M3 - SCORING: Journal article

C2 - 16256269

VL - 393

SP - 113

EP - 118

JO - NEUROSCI LETT

JF - NEUROSCI LETT

SN - 0304-3940

IS - 2-3

ER -