Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19
Standard
Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19. / Pink, Isabell; Hennigs, Jan K; Ruhl, Louisa; Sauer, Andrea; Boblitz, Lennart; Huwe, Marie; Fuge, Jan; Falk, Christine S; Pietschmann, Thomas; de Zwaan, Martina; Prasse, Antje; Kluge, Stefan; Klose, Hans; Hoeper, Marius M; Welte, Tobias.
In: INFECTION, Vol. 52, No. 2, 04.2024, p. 513-524.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Blood T cell phenotypes correlate with fatigue severity in post-acute sequelae of COVID-19
AU - Pink, Isabell
AU - Hennigs, Jan K
AU - Ruhl, Louisa
AU - Sauer, Andrea
AU - Boblitz, Lennart
AU - Huwe, Marie
AU - Fuge, Jan
AU - Falk, Christine S
AU - Pietschmann, Thomas
AU - de Zwaan, Martina
AU - Prasse, Antje
AU - Kluge, Stefan
AU - Klose, Hans
AU - Hoeper, Marius M
AU - Welte, Tobias
N1 - © 2023. The Author(s).
PY - 2024/4
Y1 - 2024/4
N2 - PURPOSE: Post-acute sequelae of COVID-19 (PASC) affect approximately 10% of convalescent patients. The spectrum of symptoms is broad and heterogeneous with fatigue being the most often reported sequela. Easily accessible blood biomarkers to determine PASC severity are lacking. Thus, our study aimed to correlate immune phenotypes with PASC across the severity spectrum of COVID-19.METHODS: A total of 176 originally immunonaïve, convalescent COVID-19 patients from a prospective cohort during the first pandemic phase were stratified by initial disease severity and underwent clinical, psychosocial, and immune phenotyping around 10 weeks after first COVID-19 symptoms. COVID-19-associated fatigue dynamics were assessed and related to clinical and immune phenotypes.RESULTS: Fatigue and severe fatigue were commonly reported irrespective of initial COVID-19 severity or organ-specific PASC. A clinically relevant increase in fatigue severity after COVID-19 was detected in all groups. Neutralizing antibody titers were higher in patients with severe acute disease, but no association was found between antibody titers and PASC. While absolute peripheral blood immune cell counts in originally immunonaïve PASC patients did not differ from unexposed controls, peripheral CD3+CD4+ T cell counts were independently correlated with fatigue severity across all strata in multivariable analysis.CONCLUSIONS: Patients were at similar risk of self-reported PASC irrespective of initial disease severity. The independent correlation between fatigue severity and blood T cell phenotypes indicates a possible role of CD4+ T cells in the pathogenesis of post-COVID-19 fatigue, which might serve as a blood biomarker.
AB - PURPOSE: Post-acute sequelae of COVID-19 (PASC) affect approximately 10% of convalescent patients. The spectrum of symptoms is broad and heterogeneous with fatigue being the most often reported sequela. Easily accessible blood biomarkers to determine PASC severity are lacking. Thus, our study aimed to correlate immune phenotypes with PASC across the severity spectrum of COVID-19.METHODS: A total of 176 originally immunonaïve, convalescent COVID-19 patients from a prospective cohort during the first pandemic phase were stratified by initial disease severity and underwent clinical, psychosocial, and immune phenotyping around 10 weeks after first COVID-19 symptoms. COVID-19-associated fatigue dynamics were assessed and related to clinical and immune phenotypes.RESULTS: Fatigue and severe fatigue were commonly reported irrespective of initial COVID-19 severity or organ-specific PASC. A clinically relevant increase in fatigue severity after COVID-19 was detected in all groups. Neutralizing antibody titers were higher in patients with severe acute disease, but no association was found between antibody titers and PASC. While absolute peripheral blood immune cell counts in originally immunonaïve PASC patients did not differ from unexposed controls, peripheral CD3+CD4+ T cell counts were independently correlated with fatigue severity across all strata in multivariable analysis.CONCLUSIONS: Patients were at similar risk of self-reported PASC irrespective of initial disease severity. The independent correlation between fatigue severity and blood T cell phenotypes indicates a possible role of CD4+ T cells in the pathogenesis of post-COVID-19 fatigue, which might serve as a blood biomarker.
U2 - 10.1007/s15010-023-02114-8
DO - 10.1007/s15010-023-02114-8
M3 - SCORING: Journal article
C2 - 37924472
VL - 52
SP - 513
EP - 524
JO - INFECTION
JF - INFECTION
SN - 0300-8126
IS - 2
ER -