Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Fabian Knörr; Christine Damm-Welk; Stephanie Ruf; Vijay Kumar Singh; Martin Zimmermann; Alfred Reiter; Wilhelm Woessmann

doi:10.3324/haematol.2017.177972

Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Standard

Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. / Knörr, Fabian; Damm-Welk, Christine; Ruf, Stephanie; Singh, Vijay Kumar; Zimmermann, Martin; Reiter, Alfred; Woessmann, Wilhelm.

In: HAEMATOLOGICA, Vol. 103, No. 3, 03.2018, p. 477-485.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Knörr, F, Damm-Welk, C, Ruf, S, Singh, VK, Zimmermann, M, Reiter, A & Woessmann, W 2018, 'Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma', HAEMATOLOGICA, vol. 103, no. 3, pp. 477-485. https://doi.org/10.3324/haematol.2017.177972

APA

Knörr, F., Damm-Welk, C., Ruf, S., Singh, V. K., Zimmermann, M., Reiter, A., & Woessmann, W. (2018). Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. HAEMATOLOGICA, 103(3), 477-485. https://doi.org/10.3324/haematol.2017.177972

Vancouver

Knörr F, Damm-Welk C, Ruf S, Singh VK, Zimmermann M, Reiter A et al. Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. HAEMATOLOGICA. 2018 Mar;103(3):477-485. https://doi.org/10.3324/haematol.2017.177972

Bibtex

@article{dbf06a775ebc4e41a8f9a9a81aeb4a51,

title = "Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma",

abstract = "Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients' anti-lymphoma immunity. We systematically correlated pretreatment concentrations of 25 cytokines with clinical and biological characteristics in a well-characterized cohort of 119 uniformly treated pediatric patients with anaplastic large cell lymphoma. Fifteen patients with anaplastic large cell lymphoma in remission and 11 patients with low-stage B-cell lymphoma served as controls. Concentrations of interleukin-9, interleukin-10, interleukin-17a, hepatocyte growth factor, soluble interleukin-2 receptor, and soluble CD30 were significantly higher in initial sera of patients than in the sera of subjects from both control groups, indicating an anaplastic large cell lymphoma-type cytokine signature. The levels of interleukin-6, interferon-γ, interferon γ-induced protein, and soluble interleukin-2 receptor correlated with the stage, initial general condition, minimal disseminated disease, anaplastic lymphoma kinase-antibody titers, and the risk of relapse among patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Only interleukin-6 showed an independent prognostic value in multivariate analyses. Pretreatment cytokine profiles in patients with anaplastic large cell lymphoma reflect a tumor signature as well as tumor burden and also differences in the strength of the patients' immune response.",

keywords = "Journal Article",

author = "Fabian Kn{\"o}rr and Christine Damm-Welk and Stephanie Ruf and Singh, {Vijay Kumar} and Martin Zimmermann and Alfred Reiter and Wilhelm Woessmann",

note = "Copyright{\textcopyright} 2018 Ferrata Storti Foundation.",

year = "2018",

month = mar,

doi = "10.3324/haematol.2017.177972",

language = "English",

volume = "103",

pages = "477--485",

journal = "HAEMATOLOGICA",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "3",

}

RIS

TY - JOUR

T1 - Blood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

AU - Knörr, Fabian

AU - Damm-Welk, Christine

AU - Ruf, Stephanie

AU - Singh, Vijay Kumar

AU - Zimmermann, Martin

AU - Reiter, Alfred

AU - Woessmann, Wilhelm

PY - 2018/3

Y1 - 2018/3

N2 - Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients' anti-lymphoma immunity. We systematically correlated pretreatment concentrations of 25 cytokines with clinical and biological characteristics in a well-characterized cohort of 119 uniformly treated pediatric patients with anaplastic large cell lymphoma. Fifteen patients with anaplastic large cell lymphoma in remission and 11 patients with low-stage B-cell lymphoma served as controls. Concentrations of interleukin-9, interleukin-10, interleukin-17a, hepatocyte growth factor, soluble interleukin-2 receptor, and soluble CD30 were significantly higher in initial sera of patients than in the sera of subjects from both control groups, indicating an anaplastic large cell lymphoma-type cytokine signature. The levels of interleukin-6, interferon-γ, interferon γ-induced protein, and soluble interleukin-2 receptor correlated with the stage, initial general condition, minimal disseminated disease, anaplastic lymphoma kinase-antibody titers, and the risk of relapse among patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Only interleukin-6 showed an independent prognostic value in multivariate analyses. Pretreatment cytokine profiles in patients with anaplastic large cell lymphoma reflect a tumor signature as well as tumor burden and also differences in the strength of the patients' immune response.

AB - Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients' anti-lymphoma immunity. We systematically correlated pretreatment concentrations of 25 cytokines with clinical and biological characteristics in a well-characterized cohort of 119 uniformly treated pediatric patients with anaplastic large cell lymphoma. Fifteen patients with anaplastic large cell lymphoma in remission and 11 patients with low-stage B-cell lymphoma served as controls. Concentrations of interleukin-9, interleukin-10, interleukin-17a, hepatocyte growth factor, soluble interleukin-2 receptor, and soluble CD30 were significantly higher in initial sera of patients than in the sera of subjects from both control groups, indicating an anaplastic large cell lymphoma-type cytokine signature. The levels of interleukin-6, interferon-γ, interferon γ-induced protein, and soluble interleukin-2 receptor correlated with the stage, initial general condition, minimal disseminated disease, anaplastic lymphoma kinase-antibody titers, and the risk of relapse among patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Only interleukin-6 showed an independent prognostic value in multivariate analyses. Pretreatment cytokine profiles in patients with anaplastic large cell lymphoma reflect a tumor signature as well as tumor burden and also differences in the strength of the patients' immune response.

KW - Journal Article

U2 - 10.3324/haematol.2017.177972

DO - 10.3324/haematol.2017.177972

M3 - SCORING: Journal article

C2 - 29242300

VL - 103

SP - 477

EP - 485

JO - HAEMATOLOGICA

JF - HAEMATOLOGICA

SN - 0390-6078

IS - 3

ER -