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Bleeding episodes in "complete, staged" versus "culprit only" revascularisation in patients with multivessel disease and ST-segment elevation myocardial infarction: a DANAMI-3-PRIMULTI substudy

Standard

Bleeding episodes in "complete, staged" versus "culprit only" revascularisation in patients with multivessel disease and ST-segment elevation myocardial infarction: a DANAMI-3-PRIMULTI substudy. / Sadjadieh, Golnaz; Engstrøm, Thomas; Helqvist, Steffen; Høfsten, Dan Eik; Køber, Lars; Pedersen, Frants; Clemmensen, Peter; Jørgensen, Erik; Saunamäki, Kari; Tilsted, Hans-Henrik; Kelbæk, Henning; Holmvang, Lene.

In: EUROINTERVENTION, Vol. 12, No. 10, 20.11.2016, p. 1231-1238.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sadjadieh, G, Engstrøm, T, Helqvist, S, Høfsten, DE, Køber, L, Pedersen, F, Clemmensen, P, Jørgensen, E, Saunamäki, K, Tilsted, H-H, Kelbæk, H & Holmvang, L 2016, 'Bleeding episodes in "complete, staged" versus "culprit only" revascularisation in patients with multivessel disease and ST-segment elevation myocardial infarction: a DANAMI-3-PRIMULTI substudy', EUROINTERVENTION, vol. 12, no. 10, pp. 1231-1238. https://doi.org/10.4244/EIJV12I10A203

APA

Sadjadieh, G., Engstrøm, T., Helqvist, S., Høfsten, D. E., Køber, L., Pedersen, F., Clemmensen, P., Jørgensen, E., Saunamäki, K., Tilsted, H-H., Kelbæk, H., & Holmvang, L. (2016). Bleeding episodes in "complete, staged" versus "culprit only" revascularisation in patients with multivessel disease and ST-segment elevation myocardial infarction: a DANAMI-3-PRIMULTI substudy. EUROINTERVENTION, 12(10), 1231-1238. https://doi.org/10.4244/EIJV12I10A203

Vancouver

Sadjadieh G, Engstrøm T, Helqvist S, Høfsten DE, Køber L, Pedersen F et al. Bleeding episodes in "complete, staged" versus "culprit only" revascularisation in patients with multivessel disease and ST-segment elevation myocardial infarction: a DANAMI-3-PRIMULTI substudy. EUROINTERVENTION. 2016 Nov 20;12(10):1231-1238. https://doi.org/10.4244/EIJV12I10A203

Bibtex

@article{b2e81f1f4f1f4e1c963609b518fb04c6,
title = "Bleeding episodes in {"}complete, staged{"} versus {"}culprit only{"} revascularisation in patients with multivessel disease and ST-segment elevation myocardial infarction: a DANAMI-3-PRIMULTI substudy",
abstract = "AIMS: The aim of this study was to evaluate whether a staged in-hospital complete revascularisation strategy increases the risk of serious bleeding events in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease.METHODS AND RESULTS: The DANAMI-3-PRIMULTI trial investigated whether a staged in-hospital complete revascularisation strategy improved outcome in patients with STEMI and multivessel disease. In this substudy, we investigated potential bleeding complications related to a second in-hospital procedure. Bleedings were assessed using BARC and TIMI criteria. Six hundred and twenty-seven (627) patients were randomised 1:1 to either PCI of the infarct-related artery (IRA) only (n=313) or complete revascularisation during a staged procedure before discharge (n=314). We found no significant difference in TIMI major+minor bleedings related to the primary PCI. There were neither major nor minor bleedings in relation to the second procedure in the complete revascularisation arm. There were significantly more in-hospital minimal+medical attention bleedings in the group randomised to complete revascularisation (61.5% vs. 49.5% in the IRA-PCI only group, p=0.003), but no difference in admission time or one-year mortality (2.2% complete revascularisation-group vs. 2.6% IRA-PCI only group, p=0.8).CONCLUSIONS: In multivessel diseased STEMI patients, a staged complete in-hospital revascularisation strategy or any second in-hospital procedure did not result in an increase in serious bleeding events.",
keywords = "Adult, Aged, Aged, 80 and over, Coronary Artery Disease/therapy, Electrocardiography/methods, Female, Hemorrhage/complications, Hospitals/statistics & numerical data, Humans, Male, Middle Aged, Myocardial Revascularization/methods, Percutaneous Coronary Intervention/methods, ST Elevation Myocardial Infarction/therapy, Treatment Outcome",
author = "Golnaz Sadjadieh and Thomas Engstr{\o}m and Steffen Helqvist and H{\o}fsten, {Dan Eik} and Lars K{\o}ber and Frants Pedersen and Peter Clemmensen and Erik J{\o}rgensen and Kari Saunam{\"a}ki and Hans-Henrik Tilsted and Henning Kelb{\ae}k and Lene Holmvang",
year = "2016",
month = nov,
day = "20",
doi = "10.4244/EIJV12I10A203",
language = "English",
volume = "12",
pages = "1231--1238",
journal = "EUROINTERVENTION",
issn = "1774-024X",
publisher = "EUROPA EDITION",
number = "10",

}

RIS

TY - JOUR

T1 - Bleeding episodes in "complete, staged" versus "culprit only" revascularisation in patients with multivessel disease and ST-segment elevation myocardial infarction: a DANAMI-3-PRIMULTI substudy

AU - Sadjadieh, Golnaz

AU - Engstrøm, Thomas

AU - Helqvist, Steffen

AU - Høfsten, Dan Eik

AU - Køber, Lars

AU - Pedersen, Frants

AU - Clemmensen, Peter

AU - Jørgensen, Erik

AU - Saunamäki, Kari

AU - Tilsted, Hans-Henrik

AU - Kelbæk, Henning

AU - Holmvang, Lene

PY - 2016/11/20

Y1 - 2016/11/20

N2 - AIMS: The aim of this study was to evaluate whether a staged in-hospital complete revascularisation strategy increases the risk of serious bleeding events in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease.METHODS AND RESULTS: The DANAMI-3-PRIMULTI trial investigated whether a staged in-hospital complete revascularisation strategy improved outcome in patients with STEMI and multivessel disease. In this substudy, we investigated potential bleeding complications related to a second in-hospital procedure. Bleedings were assessed using BARC and TIMI criteria. Six hundred and twenty-seven (627) patients were randomised 1:1 to either PCI of the infarct-related artery (IRA) only (n=313) or complete revascularisation during a staged procedure before discharge (n=314). We found no significant difference in TIMI major+minor bleedings related to the primary PCI. There were neither major nor minor bleedings in relation to the second procedure in the complete revascularisation arm. There were significantly more in-hospital minimal+medical attention bleedings in the group randomised to complete revascularisation (61.5% vs. 49.5% in the IRA-PCI only group, p=0.003), but no difference in admission time or one-year mortality (2.2% complete revascularisation-group vs. 2.6% IRA-PCI only group, p=0.8).CONCLUSIONS: In multivessel diseased STEMI patients, a staged complete in-hospital revascularisation strategy or any second in-hospital procedure did not result in an increase in serious bleeding events.

AB - AIMS: The aim of this study was to evaluate whether a staged in-hospital complete revascularisation strategy increases the risk of serious bleeding events in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease.METHODS AND RESULTS: The DANAMI-3-PRIMULTI trial investigated whether a staged in-hospital complete revascularisation strategy improved outcome in patients with STEMI and multivessel disease. In this substudy, we investigated potential bleeding complications related to a second in-hospital procedure. Bleedings were assessed using BARC and TIMI criteria. Six hundred and twenty-seven (627) patients were randomised 1:1 to either PCI of the infarct-related artery (IRA) only (n=313) or complete revascularisation during a staged procedure before discharge (n=314). We found no significant difference in TIMI major+minor bleedings related to the primary PCI. There were neither major nor minor bleedings in relation to the second procedure in the complete revascularisation arm. There were significantly more in-hospital minimal+medical attention bleedings in the group randomised to complete revascularisation (61.5% vs. 49.5% in the IRA-PCI only group, p=0.003), but no difference in admission time or one-year mortality (2.2% complete revascularisation-group vs. 2.6% IRA-PCI only group, p=0.8).CONCLUSIONS: In multivessel diseased STEMI patients, a staged complete in-hospital revascularisation strategy or any second in-hospital procedure did not result in an increase in serious bleeding events.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Coronary Artery Disease/therapy

KW - Electrocardiography/methods

KW - Female

KW - Hemorrhage/complications

KW - Hospitals/statistics & numerical data

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardial Revascularization/methods

KW - Percutaneous Coronary Intervention/methods

KW - ST Elevation Myocardial Infarction/therapy

KW - Treatment Outcome

U2 - 10.4244/EIJV12I10A203

DO - 10.4244/EIJV12I10A203

M3 - SCORING: Journal article

C2 - 27866133

VL - 12

SP - 1231

EP - 1238

JO - EUROINTERVENTION

JF - EUROINTERVENTION

SN - 1774-024X

IS - 10

ER -