Bispectral index and lower margin amplitude of the amplitude-integrated electroencephalogram in neonates
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Bispectral index and lower margin amplitude of the amplitude-integrated electroencephalogram in neonates. / Werther, Tobias; Olischar, Monika; Giordano, Vito; Czaba, Christine; Waldhoer, Thomas; Berger, Angelika; Pollak, Arnold; Deindl, Philipp.
In: NEONATOLOGY, Vol. 107, No. 1, 2015, p. 34-41.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Bispectral index and lower margin amplitude of the amplitude-integrated electroencephalogram in neonates
AU - Werther, Tobias
AU - Olischar, Monika
AU - Giordano, Vito
AU - Czaba, Christine
AU - Waldhoer, Thomas
AU - Berger, Angelika
AU - Pollak, Arnold
AU - Deindl, Philipp
N1 - © 2014 S. Karger AG, Basel.
PY - 2015
Y1 - 2015
N2 - BACKGROUND: The lower margin amplitude (LMA) of the amplitude-integrated electroencephalogram (aEEG) is suppressed in neonates during deep sedation, a feature that is attributed to the bispectral index (BIS) in adults.OBJECTIVE: We compare the BIS and the LMA of the aEEG in neonates.METHODS: Thirty neurologically healthy neonates between 37 and 44 weeks postmenstrual age were included in this study. Twenty patients received sedoanalgesic therapy for various reasons. BIS and aEEG recordings were performed simultaneously. The digital data were imported in the numerical software environment Matlab®. The LMA of the aEEG was computed on a 1-min time scale and synchronized with the BIS data. The correlation between the time-dependent variables BIS and LMA was estimated using the Spearman rank correlation index.RESULTS: The median correlation between BIS and LMA was 0.3. Inclusion of recordings of high signal quality only into analysis improved the median correlation index to 0.6.CONCLUSIONS: We found a light-to-moderate correlation between BIS and LMA in our study cohort and a good correlation in the subgroup with high signal quality.
AB - BACKGROUND: The lower margin amplitude (LMA) of the amplitude-integrated electroencephalogram (aEEG) is suppressed in neonates during deep sedation, a feature that is attributed to the bispectral index (BIS) in adults.OBJECTIVE: We compare the BIS and the LMA of the aEEG in neonates.METHODS: Thirty neurologically healthy neonates between 37 and 44 weeks postmenstrual age were included in this study. Twenty patients received sedoanalgesic therapy for various reasons. BIS and aEEG recordings were performed simultaneously. The digital data were imported in the numerical software environment Matlab®. The LMA of the aEEG was computed on a 1-min time scale and synchronized with the BIS data. The correlation between the time-dependent variables BIS and LMA was estimated using the Spearman rank correlation index.RESULTS: The median correlation between BIS and LMA was 0.3. Inclusion of recordings of high signal quality only into analysis improved the median correlation index to 0.6.CONCLUSIONS: We found a light-to-moderate correlation between BIS and LMA in our study cohort and a good correlation in the subgroup with high signal quality.
U2 - 10.1159/000365277
DO - 10.1159/000365277
M3 - SCORING: Journal article
C2 - 25323947
VL - 107
SP - 34
EP - 41
JO - NEONATOLOGY
JF - NEONATOLOGY
SN - 1661-7800
IS - 1
ER -