Bioreactor design for tissue engineering.
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Bioreactor design for tissue engineering. / Pörtner, Ralf; Nagel-Heyer, Stephanie; Goepfert, Christiane; Adamietz, Peter; Meenen, Norbert.
In: J BIOSCI BIOENG, Vol. 100, No. 3, 3, 2005, p. 235-245.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Bioreactor design for tissue engineering.
AU - Pörtner, Ralf
AU - Nagel-Heyer, Stephanie
AU - Goepfert, Christiane
AU - Adamietz, Peter
AU - Meenen, Norbert
PY - 2005
Y1 - 2005
N2 - Bioreactor systems play an important role in tissue engineering, as they enable reproducible and controlled changes in specific environmental factors. They can provide technical means to perform controlled studies aimed at understanding specific biological, chemical or physical effects. Furthermore, bioreactors allow for a safe and reproducible production of tissue constructs. For later clinical applications, the bioreactor system should be an advantageous method in terms of low contamination risk, ease of handling and scalability. To date the goals and expectations of bioreactor development have been fulfilled only to some extent, as bioreactor design in tissue engineering is very complex and still at an early stage of development. In this review we summarize important aspects for bioreactor design and provide an overview on existing concepts. The generation of three dimensional cartilage-carrier constructs is described to demonstrate how the properties of engineered tissues can be improved significantly by combining biological and engineering knowledge. In the future, a very intimate collaboration between engineers and biologists will lead to an increased fundamental understanding of complex issues that can have an impact on tissue formation in bioreactors.
AB - Bioreactor systems play an important role in tissue engineering, as they enable reproducible and controlled changes in specific environmental factors. They can provide technical means to perform controlled studies aimed at understanding specific biological, chemical or physical effects. Furthermore, bioreactors allow for a safe and reproducible production of tissue constructs. For later clinical applications, the bioreactor system should be an advantageous method in terms of low contamination risk, ease of handling and scalability. To date the goals and expectations of bioreactor development have been fulfilled only to some extent, as bioreactor design in tissue engineering is very complex and still at an early stage of development. In this review we summarize important aspects for bioreactor design and provide an overview on existing concepts. The generation of three dimensional cartilage-carrier constructs is described to demonstrate how the properties of engineered tissues can be improved significantly by combining biological and engineering knowledge. In the future, a very intimate collaboration between engineers and biologists will lead to an increased fundamental understanding of complex issues that can have an impact on tissue formation in bioreactors.
KW - Animals
KW - Humans
KW - Bioreactors
KW - Biotechnology/instrumentation
KW - Cartilage/cytology
KW - Tissue Engineering/instrumentation
KW - Animals
KW - Humans
KW - Bioreactors
KW - Biotechnology/instrumentation
KW - Cartilage/cytology
KW - Tissue Engineering/instrumentation
M3 - SCORING: Journal article
VL - 100
SP - 235
EP - 245
JO - J BIOSCI BIOENG
JF - J BIOSCI BIOENG
SN - 1389-1723
IS - 3
M1 - 3
ER -
