Biophysically motivated efficient estimation of the spatially isotropic R 2 * component from a single gradient-recalled echo measurement

TY - JOUR

T1 - Biophysically motivated efficient estimation of the spatially isotropic R 2 * component from a single gradient-recalled echo measurement

AU - Papazoglou, Sebastian

AU - Streubel, Tobias

AU - Ashtarayeh, Mohammad

AU - Pine, Kerrin J

AU - Edwards, Luke J

AU - Brammerloh, Malte

AU - Kirilina, Evgeniya

AU - Morawski, Markus

AU - Jäger, Carsten

AU - Geyer, Stefan

AU - Callaghan, Martina F

AU - Weiskopf, Nikolaus

AU - Mohammadi, Siawoosh

N1 - © 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.

PY - 2019/11

Y1 - 2019/11

N2 - PURPOSE: To propose and validate an efficient method, based on a biophysically motivated signal model, for removing the orientation-dependent part of R 2 * using a single gradient-recalled echo (GRE) measurement.METHODS: The proposed method utilized a temporal second-order approximation of the hollow-cylinder-fiber model, in which the parameter describing the linear signal decay corresponded to the orientation-independent part of R 2 * . The estimated parameters were compared to the classical, mono-exponential decay model for R 2 * in a sample of an ex vivo human optic chiasm (OC). The OC was measured at 16 distinct orientations relative to the external magnetic field using GRE at 7T. To show that the proposed signal model can remove the orientation dependence of R 2 * , it was compared to the established phenomenological method for separating R 2 * into orientation-dependent and -independent parts.RESULTS: Using the phenomenological method on the classical signal model, the well-known separation of R 2 * into orientation-dependent and -independent parts was verified. For the proposed model, no significant orientation dependence in the linear signal decay parameter was observed.CONCLUSIONS: Since the proposed second-order model features orientation-dependent and -independent components at distinct temporal orders, it can be used to remove the orientation dependence of R 2 * using only a single GRE measurement.

AB - PURPOSE: To propose and validate an efficient method, based on a biophysically motivated signal model, for removing the orientation-dependent part of R 2 * using a single gradient-recalled echo (GRE) measurement.METHODS: The proposed method utilized a temporal second-order approximation of the hollow-cylinder-fiber model, in which the parameter describing the linear signal decay corresponded to the orientation-independent part of R 2 * . The estimated parameters were compared to the classical, mono-exponential decay model for R 2 * in a sample of an ex vivo human optic chiasm (OC). The OC was measured at 16 distinct orientations relative to the external magnetic field using GRE at 7T. To show that the proposed signal model can remove the orientation dependence of R 2 * , it was compared to the established phenomenological method for separating R 2 * into orientation-dependent and -independent parts.RESULTS: Using the phenomenological method on the classical signal model, the well-known separation of R 2 * into orientation-dependent and -independent parts was verified. For the proposed model, no significant orientation dependence in the linear signal decay parameter was observed.CONCLUSIONS: Since the proposed second-order model features orientation-dependent and -independent components at distinct temporal orders, it can be used to remove the orientation dependence of R 2 * using only a single GRE measurement.

U2 - 10.1002/mrm.27863

DO - 10.1002/mrm.27863

M3 - SCORING: Journal article

C2 - 31293007

VL - 82

SP - 1804

EP - 1811

JO - MAGN RESON MED

JF - MAGN RESON MED

SN - 0740-3194

IS - 5

ER -