Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study
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Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study. / Palm, Frederick; Lahdentausta, Laura; Sorsa, Timo; Tervahartiala, Taina; Gokel, Pia; Buggle, Florian; Safer, Anton; Becher, Heiko; Grau, Armin J; Pussinen, Pirkko.
In: INNATE IMMUN-LONDON, Vol. 20, No. 5, 2014, p. 511-518.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study
AU - Palm, Frederick
AU - Lahdentausta, Laura
AU - Sorsa, Timo
AU - Tervahartiala, Taina
AU - Gokel, Pia
AU - Buggle, Florian
AU - Safer, Anton
AU - Becher, Heiko
AU - Grau, Armin J
AU - Pussinen, Pirkko
N1 - © The Author(s) 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
PY - 2014
Y1 - 2014
N2 - Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98 patients with acute ischemic stroke (mean ± SD, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). Patients were more often edentulous and had fewer teeth than controls (13.8 ± 10.8 versus 16.6 ± 10.1). After adjusting for stroke risk factors and number of teeth, controls had higher saliva matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), IL-1β, Aggregatibacter actinomycetemcomitans, and serum LPS activity levels. Patients had higher serum MMP-8 and MPO, and they were more often qPCR-positive for A. actinomycetemcomitans (37.9% versus 19.0%) and for ≥3 periodontopathic species combined (50.0% versus 33.0%). We conclude that controls more often had evidence of current periodontal infection with higher periodontal pathogen amount, endotoxemia, local inflammation and tissue destruction. Stroke patients more often had evidence of end-stage periodontitis with edentulism and missing teeth. They were more often carriers of several periodontopathic pathogens in saliva, especially A. actinomycetemcomitans. Additionally, inflammatory burden may contribute to high systemic inflammation associated with elevated stroke susceptibility.
AB - Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98 patients with acute ischemic stroke (mean ± SD, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). Patients were more often edentulous and had fewer teeth than controls (13.8 ± 10.8 versus 16.6 ± 10.1). After adjusting for stroke risk factors and number of teeth, controls had higher saliva matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), IL-1β, Aggregatibacter actinomycetemcomitans, and serum LPS activity levels. Patients had higher serum MMP-8 and MPO, and they were more often qPCR-positive for A. actinomycetemcomitans (37.9% versus 19.0%) and for ≥3 periodontopathic species combined (50.0% versus 33.0%). We conclude that controls more often had evidence of current periodontal infection with higher periodontal pathogen amount, endotoxemia, local inflammation and tissue destruction. Stroke patients more often had evidence of end-stage periodontitis with edentulism and missing teeth. They were more often carriers of several periodontopathic pathogens in saliva, especially A. actinomycetemcomitans. Additionally, inflammatory burden may contribute to high systemic inflammation associated with elevated stroke susceptibility.
U2 - 10.1177/1753425913501214
DO - 10.1177/1753425913501214
M3 - SCORING: Journal article
C2 - 24045341
VL - 20
SP - 511
EP - 518
JO - INNATE IMMUN-LONDON
JF - INNATE IMMUN-LONDON
SN - 1753-4259
IS - 5
ER -